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ClinicalTrials.gov 101 recruiting now official registry

Pancreatic Cancer clinical trials

Every US clinical trial registered for Pancreatic Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

283 US clinical trials · 101 currently recruiting

The research picture

Pancreatic Cancer has 283 registered US clinical trials, 101 of them open to new participants right now — about 36% of the total.

101
recruiting participants now
36%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
19
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 999,999 participants

Integrated Cancer Repository for Cancer Research

University of Nebraska

NCT02012699

RECRUITING 20,000 participants

Collecting Medical Information and Tissue Samples From Patients With Pancreatic Cancer or Other Pancreatic Disorders

Mayo Clinic

NCT00830557

RECRUITING 10,000 participants

Pancreatic Adenocarcinoma Gene Environment Risk Study

University of Pittsburgh

NCT00912717

RECRUITING 9,600 participants

Sample Collection for Ongoing Research and Product Evaluation Study

Natera

NCT07318051

RECRUITING Early Phase 1 5,000 participants

Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

Dana-Farber Cancer Institute

NCT06122896

RECRUITING 5,000 participants

A Prospective Registry for Patients at High-Risk for Pancreatic Cancer

Mayo Clinic

NCT06151223

RECRUITING 5,000 participants

Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients

Vanderbilt University Medical Center

NCT00899626

RECRUITING 4,000 participants

UCSF PANC Cyst Registry

University of California, San Francis

NCT04291651

RECRUITING 2,000 participants

Pancreatic Cancer Detection Consortium

City of Hope Medical Center

NCT06388967

RECRUITING 1,400 participants

EXoPERT EMERALD Clinical Study

EXoPERT

NCT07186296

RECRUITING 1,174 participants

Using Radiogenomics to Predict Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas

H. Lee Moffitt Cancer Center and Research Institute

NCT04275557

RECRUITING NA 1,020 participants

Video Education With Result Dependent dIsclosure

Dana-Farber Cancer Institute

NCT05225428

RECRUITING 1,000 participants

PANCREATIC DISEASE COHORT A Registry and Biospecimen Bank to Better Understand Pancreatic Disease

Columbia University

NCT01102556

RECRUITING 800 participants

A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus

Nuvance Health

NCT03937453

RECRUITING 775 participants

Evaluation of a Mixed Meal Test for Diagnosis and Characterization and Type 3c Diabetes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis (DETECT)

M.D. Anderson Cancer Center

NCT03460769

RECRUITING 700 participants

A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT03334708

RECRUITING 620 participants

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

University of Missouri-Columbia

NCT02838836

RECRUITING Phase 3 614 participants

A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

Astellas Pharma Global Development

NCT07409272

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 1 512 participants

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

AbbVie

NCT05005403

RECRUITING Phase 3 500 participants

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Revolution Medicines

NCT07252232

RECRUITING 500 participants

American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry

University of Louisville

NCT02674100

RECRUITING Phase 1 490 participants

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06238479

RECRUITING NA 445 participants

Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT04751435

RECRUITING Phase 1 420 participants

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Eli Lilly and Company

NCT06465069

RECRUITING Phase 1 405 participants

A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

ArriVent BioPharma

NCT07066657

RECRUITING Phase 1 403 participants

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Frontier Medicines Corporation

NCT06244771

RECRUITING 320 participants

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

University of Missouri-Columbia

NCT03551951

RECRUITING 310 participants

Artificial Intelligence in Endoscopic Ultrasound

Orlando Health

NCT06564571

RECRUITING NA 259 participants

Computed Tomography in Diagnosing Patients With Pancreatic or Hepatobiliary Cancer

M.D. Anderson Cancer Center

NCT02361320

RECRUITING NA 257 participants

Resilience and Equity in Aging, Cancer, and Health (REACH)

Dana-Farber Cancer Institute

NCT04674267

RECRUITING Phase 1 250 participants

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

EMD Serono Research & Development Institute

NCT06710132

RECRUITING Phase 1 242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

VM Oncology

NCT03556228

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING Phase 1 220 participants

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

Bold Therapeutics

NCT04421820

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING 200 participants

Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

Abramson Cancer Center at Penn Medicine

NCT02478892

RECRUITING Phase 1 195 participants

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

PAQ Therapeutics

NCT07300150

RECRUITING 181 participants

Interrogation of Exosome-mediated Intercellular Signaling in Patients With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT02393703

RECRUITING NA 178 participants

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

Reema A. Patel

NCT05391126

RECRUITING Phase 1 165 participants

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pheon Therapeutics

NCT07127874

RECRUITING Phase 1 150 participants

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

Qurgen

NCT05989724

RECRUITING NA 140 participants

EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope

Orlando Health

NCT06340620

RECRUITING Phase 1 134 participants

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

RasCal Therapeutics

NCT04678648

RECRUITING NA 134 participants

Stereotactic Adaptive Radiation Therapy of Borderline Resectable Pancreatic Cancer an Individualized Approach

Varian, a Siemens Healthineers Company

NCT05764720

RECRUITING Phase 2 125 participants

Pancreatic Cancer Adaptive Neoadjuvant Chemotherapy Trial

Medical College of Wisconsin

NCT03322995

RECRUITING 125 participants

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

H. Lee Moffitt Cancer Center and Research Institute

NCT05687188

RECRUITING Phase 1 124 participants

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

National Cancer Institute (NCI)

NCT02830724

RECRUITING Phase 1 122 participants

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

AtlasMedx, Incorporated

NCT04503265

RECRUITING 120 participants

A First-in-Human Study of FID-022 in Solid Tumor Patients

H. Lee Moffitt Cancer Center and Research Institute

NCT07249775

RECRUITING Phase 1 110 participants

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

National Cancer Institute (NCI)

NCT03190941

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING NA 102 participants

Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma

Medical College of Wisconsin

NCT03704662

RECRUITING 100 participants

Pancreatic Cancer Genetics

Columbia University

NCT01102569

RECRUITING Phase 1 92 participants

AOH1996 for the Treatment of Refractory Solid Tumors

City of Hope Medical Center

NCT05227326

RECRUITING NA 85 participants

A Study of Multiparametric Ultrasound Imaging Methods

Memorial Sloan Kettering Cancer Center

NCT07270237

RECRUITING Phase 2 84 participants

PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples

Medical College of Wisconsin

NCT04683315

RECRUITING Phase 1 80 participants

Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

CivaTech Oncology

NCT02843945

RECRUITING NA 80 participants

Support Through Remote Observation and Nutrition Guidance Program (STRONG-PCS)

H. Lee Moffitt Cancer Center and Research Institute

NCT06001268

RECRUITING Phase 1 80 participants

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Angiex

NCT06440005

RECRUITING Phase 1 80 participants

First in Human Phase1/2a Clinical Trial of Anti-PAUF Monoclonal Antibody PBP1510 in Patients With Pancreatic Cancer

Prestige Biopharma Limited

NCT05141149

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 66 participants

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

Lumicell

NCT02584244

RECRUITING Phase 2 60 participants

Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

Proton Collaborative Group

NCT02598349

RECRUITING NA 60 participants

High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

M.D. Anderson Cancer Center

NCT05053555

RECRUITING NA 60 participants

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Washington University School of Medicine

NCT05975593

RECRUITING NA 55 participants

Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response

Ohio State University

NCT04588025

RECRUITING Phase 1 54 participants

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06411691

RECRUITING Phase 1 51 participants

Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

M.D. Anderson Cancer Center

NCT05922930

RECRUITING Phase 1 51 participants

MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Washington University School of Medicine

NCT06648434

RECRUITING Phase 2 46 participants

Study of Amplitude-Modulated Radiofrequency Electromagnetic Fields in Metastatic Pancreatic Cancer

THERABIONIC

NCT05776524

RECRUITING 46 participants

WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment

Wake Forest University Health Sciences

NCT06291324

RECRUITING Early Phase 1 46 participants

Lidocaine Infusion in Pancreatic Cancer

University of Illinois at Chicago

NCT04048278

RECRUITING Phase 1 45 participants

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

UNC Lineberger Comprehensive Cancer Center

NCT03454035

RECRUITING NA 45 participants

Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial

Dana-Farber Cancer Institute

NCT05356117

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 38 participants

Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06782932

RECRUITING Phase 1 37 participants

Mutant KRAS -Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05013216

RECRUITING Phase 1 36 participants

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

M.D. Anderson Cancer Center

NCT05394259

RECRUITING NA 30 participants

Alpha Radiation Emitters Device for the Treatment of Pancreatic Cancer With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

Alpha Tau Medical

NCT06698458

RECRUITING NA 26 participants

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Memorial Sloan Kettering Cancer Center

NCT05837767

RECRUITING Phase 1 26 participants

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

Lantheus Medical Imaging

NCT06298916

RECRUITING Phase 1 26 participants

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

PanTher Therapeutics

NCT06673017

RECRUITING NA 26 participants

Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06423963

RECRUITING Phase 2 25 participants

Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer

Icahn School of Medicine at Mount Sinai

NCT05462496

RECRUITING Phase 1 25 participants

Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05141513

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

RECRUITING Phase 1 23 participants

Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer

University of Virginia

NCT06479239

RECRUITING Phase 1 21 participants

Onvansertib in Combination With NALIRIFOX for First Line Treatment of Advanced Pancreatic Cancer

University of Kansas Medical Center

NCT06736717

RECRUITING Phase 2 20 participants

NC410 and FOLFIRINOX in Combination With Nivolumab With or Without Ipilimumab in Patients With Untreated Metastatic Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06941857

RECRUITING Phase 1 20 participants

A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

University of Rochester

NCT04477343

RECRUITING Early Phase 1 20 participants

Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

Cedars-Sinai Medical Center

NCT05086250

RECRUITING Phase 1 18 participants

Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma

Diakonos Oncology Corporation

NCT04157127

RECRUITING Phase 1 18 participants

Intra-tumoral Mitazalimab (CD40 Antibody) With Irreversible Electroporation (IRE) in Locally Advanced Pancreas Cancer

University of California, San Diego

NCT06205849

RECRUITING Phase 1 15 participants

EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

NYU Langone Health

NCT05723107

RECRUITING NA 15 participants

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

University of California, Irvine

NCT05497531

RECRUITING 12 participants

Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer

West Virginia University

NCT05535894

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING Phase 1 10 participants

A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer

NYU Langone Health

NCT05984602

RECRUITING Early Phase 1 10 participants

Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer

Northwell Health

NCT07254091

Phase Distribution

PhaseTrial count
Phase 1 114
Phase 2 66
Phase 3 10
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Cancer Trial Landscape

ClinicalTrials.gov lists 283 US studies indexed under Pancreatic Cancer, and 101 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pancreatic Cancer shows 12 late-stage studies (Phase 3 and Phase 4 combined) alongside 180 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pancreatic Cancer is led by Memorial Sloan Kettering Cancer Center with 19 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Cancer?

PlainTrial tracks 283 US clinical trials for Pancreatic Cancer, of which 101 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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