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NCT04657432 · ClinicalTrials.gov registry record · NA
Brief, High-dose rTMS for Depression
A NA study of Depression and Anxiety, sponsored by Medical University of South Carolina.
- Active
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT04657432: Active NA study of Depression and Anxiety, sponsored by Medical University of South Carolina.
NCT04657432 is a NA study of Depression and Anxiety that is active but no longer recruiting, run by Medical University of South Carolina. The registered enrollment target is 70 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04657432, a NA study of Depression and Anxiety, is active but no longer recruiting, sponsored by Medical University of South Carolina.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of individual variations of their functional networks compared to the site of stimulation and clinical outcomes.
Primary Outcome
Depression severity as assessed by: 1\. Hamilton Scale for Depression (HAM-D) Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine are scored from 0-2. 10 - 13 mild; 14-17 mild to moderate; \>17 moderate to severe.
Conditions Studied
Interventions
- DEVICE Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2021-05-25 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What the registry record for NCT04657432 still lists
NCT04657432 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which Repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.
NCT04657432 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT04657432 about?
NCT04657432 is a clinical study titled "Brief, High-dose rTMS for Depression". High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol ...
What is the current status of trial NCT04657432?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 70 participants. The study started on 2021-05-25. Estimated completion is 2026-12-01.
What conditions does trial NCT04657432 study?
This clinical trial studies the following conditions: Depression, Anxiety.
What interventions are being tested in trial NCT04657432?
The interventions under investigation include: Repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE).
Who is sponsoring clinical trial NCT04657432?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04657432 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04657432's enrollment target sits among peer trials
70 407th of 679 higher than 266 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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