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NCT05008198 · ClinicalTrials.gov registry record
Assessing an EEG Biomarker of Response to TMS for Major Depression
A clinical trial of Depression, sponsored by VA Office of Research and Development.
- Active
- Registry status
- 266
- Enrollment target
- 1
- Study location
NCT05008198: Active study of Depression, sponsored by VA Office of Research and Development.
NCT05008198 is a study of Depression that is active but no longer recruiting, run by VA Office of Research and Development. The registered enrollment target is 266 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05008198, a study of Depression, is active but no longer recruiting, sponsored by VA Office of Research and Development.
- ACTIVE NOT RECRUITING
- Registry status
- 266 participants
- Enrollment target
- 1
- Study location
Study Summary
Veterans with treatment resistant depression (TRD) have the opportunity to receive transcranial magnetic stimulation (TMS) treatment via the VA's National TMS Clinical Pilot Program. While some see improvement with their depression, others do not. Therefore, it may be beneficial to be able to predict with biomarkers what participants may see improvement with their treatment. Electroencephalography (EEG) is a means to identify such biomarkers. Four hundred Veterans with TRD will be enrolled in this trial to determine whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. Participants will have a total of EEG scans at baseline, every 5th treatment session, and at the end of treatment for a total of 7 EEG scans.
Primary Outcome
The IDS-SR is a 30-item self-report depressive symptom severity rating scale. The IDS-SR has been shown to have highly acceptable psychometric properties and has been found to be a treatment sensitive measures of symptom severity in depression. Each question is on a scale of 0 to 4. The IDS-SR has a score range between 0 to 84, with a higher score reflecting higher symptom severity in depression.
Conditions Studied
Interventions
- OTHER Transcranial Magnetic Stimulation
Study Locations (1)
Vermont
- White River Junction VA Medical Center, White River Junction, VT - White River Junction
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 266 participants |
| Start Date | 2021-08-19 |
| Est. Completion | 2026-09-30 |
What the registry record for NCT05008198 still lists
NCT05008198 is an observational study that tracks outcomes without assigning an intervention. The registered 266 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (66% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 1 intervention - of which Transcranial Magnetic Stimulation is the first listed.
NCT05008198 reports a single indexed study location in Vermont.
Frequently Asked Questions
What is clinical trial NCT05008198 about?
NCT05008198 is a clinical study titled "Assessing an EEG Biomarker of Response to TMS for Major Depression". Veterans with treatment resistant depression (TRD) have the opportunity to receive transcranial magnetic stimulation (TMS) treatment via the VA's National TMS Clinical Pilot Program. While some see improvement with their depression, others do not. Therefore, it may be beneficial to be able to predic...
What is the current status of trial NCT05008198?
This trial is currently active not recruiting. The enrollment target is 266 participants. The study started on 2021-08-19. Estimated completion is 2026-09-30.
What conditions does trial NCT05008198 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT05008198?
The interventions under investigation include: Transcranial Magnetic Stimulation (OTHER).
Who is sponsoring clinical trial NCT05008198?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05008198 being conducted?
This trial has 1 study location across Vermont. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05008198's enrollment target sits among peer trials
266 166th of 679 higher than 514 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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