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NCT06458192 · ClinicalTrials.gov registry record · NA
Adaptive Messaging to Support Depression Self-Management
A NA study of Depression, sponsored by Northwestern University.
- Active
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06458192: Active NA study of Depression, sponsored by Northwestern University.
NCT06458192 is a NA study of Depression that is active but no longer recruiting, run by Northwestern University. The registered enrollment target is 100 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06458192, a NA study of Depression, is active but no longer recruiting, sponsored by Northwestern University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a pilot randomized controlled trial of an adaptive 8-week text messaging intervention for depression self-management. Among 100 individuals with elevated depression symptoms, the investigators will compare the effects of 8 weeks of the adaptive text messaging intervention (n=40) to 8 weeks of a non-adaptive text messaging intervention (n=40), and 8 weeks of a psychoeducation-only intervention (n=20). The investigators will include a 6-month post-treatment follow-up to verify that treatment gains are maintained. Both messaging arms will receive 8 weeks of daily text messaging. Messages will prompt learning and applying cognitive and behavioral self-management strategies. Whereas the non-adaptive messaging system will randomly select daily messaging styles (representing a variety of self-management strategies and message tones), the adaptive messaging system will apply reinforcement learning to select daily messaging styles to maximize user engagement. Text messages will also be used to solicit feedback such as message ratings to inform the reinforcement learning algorithm (if applicable). The psychoeducation control group will receive a few brief text messages per week providing weblinks to access psychoeducation information. The investigators will recruit participants through digital methods (e.g., advertising on social media platforms like Facebook and Instagram). Administration of study measures will occur at baseline, weeks 4 and 8, and 3-month and 6-month follow-up. The primary outcomes is depression symptom severity (PHQ-9). Secondary outcomes are: anxiety severity (GAD-7) and suicidality (DSI-SS). Using an Intention to Treat paradigm, the investigators will test our hypothesis that: H1: Relative to the psychoeducation-only control, messaging interventions will reduce depression (H1a) and anxiety and suicidal ideation (H1b). H2: Relative to non-adaptive messaging, adaptive messaging will reduce depression (H1a) and anxiety and suicidality (H2b). H
Primary Outcome
PHQ-9 is a 9-item questionnaire which produces a single score between 0 and 27, with higher scores indicating greater depression symptom severity.
Conditions Studied
Interventions
- BEHAVIORAL Adaptive Messaging Intervention
- BEHAVIORAL Non-Adaptive Messaging Intervention
- BEHAVIORAL Psychoeducation-Only Control
Study Locations (1)
Illinois
- Northwestern University - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-01-13 |
| Est. Completion | 2025-12-18 |
| Phase | NA |
What the registry record for NCT06458192 still lists
NCT06458192 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 3 interventions - of which Adaptive Messaging Intervention is the first listed.
NCT06458192 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06458192 about?
NCT06458192 is a clinical study titled "Adaptive Messaging to Support Depression Self-Management". This is a pilot randomized controlled trial of an adaptive 8-week text messaging intervention for depression self-management. Among 100 individuals with elevated depression symptoms, the investigators will compare the effects of 8 weeks of the adaptive text messaging intervention (n=40) to 8 weeks o...
What is the current status of trial NCT06458192?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-01-13. Estimated completion is 2025-12-18.
What conditions does trial NCT06458192 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT06458192?
The interventions under investigation include: Adaptive Messaging Intervention (BEHAVIORAL), Non-Adaptive Messaging Intervention (BEHAVIORAL), Psychoeducation-Only Control (BEHAVIORAL).
Who is sponsoring clinical trial NCT06458192?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06458192 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06458192's enrollment target sits among peer trials
100 326th of 679 higher than 331 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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