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Alcohol Use Disorder clinical trials
109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.
185 US clinical trials · 109 currently recruiting
Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.
The research picture
Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.
- 109
- recruiting participants now
- 59%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Yale University
Active & Recent Trials
185 total, page 2 of 4
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
Neural Correlates During Alcohol Intoxication
Ohio State University
NCT06118580
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Medical University of South Carolina
NCT05786157
Automated Reinforcement Management Systems, Phase II
Washington State University
NCT06456905
Cerebellar Involvement in Alcohol Use Disorder (AUD)
Johns Hopkins University
NCT05732207
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
Shirish S Barve
NCT06005298
StuDy AimED at Increasing AlCohol AbsTinEnce
University of Illinois at Chicago
NCT05778734
Neural and Hormonal Influences on Sex Differences in Risk for AUD
Jessica Weafer
NCT04929288
Amplification of Positivity for Alcohol Use
Laureate Institute for Brain Research
NCT06030154
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
Yale University
NCT05957159
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
Milky Kohno
NCT06426303
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
University of Texas at Austin
NCT05838274
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
Yale University
NCT06489782
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
University of Oregon
NCT05684094
A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
Auburn University
NCT05621538
MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
Medical University of South Carolina
NCT04998916
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial
University of Iowa
NCT06405607
Neuromodulation and Cognitive Training for Substance Use Disorders
University of Minnesota
NCT04426214
Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder
VA Office of Research and Development
NCT06399653
rTMS as Add on Treatment for Substance Use Disorders
Yale University
NCT06963476
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
Virginia Commonwealth University
NCT05548452
Evaluating a One-Year Version of the Parent-Child Assistance Program
University of Oklahoma
NCT06163651
A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol
The Mind Research Network
NCT04770025
The Impact of Heavy Alcohol Use on Saliva and Oral Health
National Institutes of Health Clinical Center (CC)
NCT06684483
COMT Inhibition Among Individuals With Comorbid AUD/ADHD
University of Colorado, Denver
NCT03904498
Naltrexone in AUD Reward Drinkers
University of Pennsylvania
NCT05028062
LGG Supplementation in Patients With AUD and ALD
University of Louisville
NCT05178069
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
University of Notre Dame
NCT07342504
Improving Remote Breathalyzer Procedures Used by Clinicians and Researchers to Remotely Monitor Alcohol Use
University of North Texas, Denton, TX
NCT05641389
Anxiety During Abstinence in AUD
Columbia University
NCT06793488
Citicoline in Youth Alcohol Use Disorder
Medical University of South Carolina
NCT05870111
Semaglutide Therapy for Alcohol Reduction (STAR)
National Institute on Drug Abuse (NIDA)
NCT06015893
Drinking, Acetate, and Stress
Yale University
NCT06584448
Mobile Platform for Optimizing Wellness and Engagement in Recovery
University of Michigan
NCT07178990
Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)
University of Michigan
NCT07413458
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT06269627
Environment and Alcohol: A Pilot Study
National Institute on Drug Abuse (NIDA)
NCT06860607
Tirzepatide for Alcohol Use Disorder
University of Southern California
NCT06994338
Intranasal Insulin for Treatment of Alcohol Use Disorder
Brown University
NCT05988632
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
University of Rochester
NCT05943171
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
VA Palo Alto Health Care System
NCT06415721
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
University of Minnesota
NCT05062369
PT150 Drug for Use in Alcohol Use Disorder
Pop Test Oncology
NCT06712602
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
National Institute of Mental Health (NIMH)
NCT07027839
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
National Institute of Mental Health (NIMH)
NCT06795581
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
University of Pennsylvania
NCT06559995
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1
Yale University
NCT06004830
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2
Yale University
NCT06006143
CM for Patients With ALD After Liver Transplant
Arpan A. Patel, MD
NCT06304467
Suvorexant and Alcohol
William Stoops
NCT06326684
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 49 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alcohol Use Disorder Trial Landscape
185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).
Phase mix: 8 late (III/IV) vs 75 early (I/II).
Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alcohol Use Disorder?
PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alcohol Use Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.