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Alcohol Use Disorder: early-phase trial registry
109 of 185 indexed Alcohol Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #60 of 28,707 conditions by registered trial count.
185 US clinical trials · 109 currently recruiting · #60 of 28,707 conditions by registered trial count
Alcohol Use Disorder: 185 US clinical trials tracked, 109 recruiting.
Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.
Enrollment posture brief
Registry condition alcohol-use-disorder
OPEN 109 | RECR 59% | LATE 8 | EARLY 75 | RANK #60 | SPON 13
Volume-matched condition peers
Nearest open-share peer: Breast Carcinoma (59% recruiting · 107 trials)
Alcohol Use Disorder lists 109 open slots (59% of 185 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Alcohol Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Alcohol Use Disorder is recruiting above its size-band peers.
109 of 185 indexed trials (58.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Alcohol Use Disorder trials is spread across many organizations.
Yale University accounts for 13 of 185 trials (7%). 91 distinct sponsors appear on at least one study for this condition label.
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Typical Alcohol Use Disorder enrolment sits around 90 participants.
Median target enrolment is 90 among the 185 trials that report a genuine target (sentinel values excluded). 99 of those (53.5%) plan for fewer than 100 participants.
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Alcohol Use Disorder research is mostly interventional.
173 interventional and 12 observational studies make up this index (93.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
185 total, page 2 of 4
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
Neural Correlates During Alcohol Intoxication
Ohio State University
NCT06118580
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Medical University of South Carolina
NCT05786157
Automated Reinforcement Management Systems, Phase II
Washington State University
NCT06456905
Cerebellar Involvement in Alcohol Use Disorder (AUD)
Johns Hopkins University
NCT05732207
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
Shirish S Barve
NCT06005298
StuDy AimED at Increasing AlCohol AbsTinEnce
University of Illinois at Chicago
NCT05778734
Neural and Hormonal Influences on Sex Differences in Risk for AUD
Jessica Weafer
NCT04929288
Amplification of Positivity for Alcohol Use
Laureate Institute for Brain Research
NCT06030154
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
Yale University
NCT05957159
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
Milky Kohno
NCT06426303
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
University of Texas at Austin
NCT05838274
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
Yale University
NCT06489782
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
University of Oregon
NCT05684094
A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
Auburn University
NCT05621538
MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
Medical University of South Carolina
NCT04998916
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial
University of Iowa
NCT06405607
Neuromodulation and Cognitive Training for Substance Use Disorders
University of Minnesota
NCT04426214
Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder
VA Office of Research and Development
NCT06399653
rTMS as Add on Treatment for Substance Use Disorders
Yale University
NCT06963476
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
Virginia Commonwealth University
NCT05548452
Evaluating a One-Year Version of the Parent-Child Assistance Program
University of Oklahoma
NCT06163651
A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol
The Mind Research Network
NCT04770025
The Impact of Heavy Alcohol Use on Saliva and Oral Health
National Institutes of Health Clinical Center (CC)
NCT06684483
COMT Inhibition Among Individuals With Comorbid AUD/ADHD
University of Colorado, Denver
NCT03904498
Naltrexone in AUD Reward Drinkers
University of Pennsylvania
NCT05028062
LGG Supplementation in Patients With AUD and ALD
University of Louisville
NCT05178069
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
University of Notre Dame
NCT07342504
Improving Remote Breathalyzer Procedures Used by Clinicians and Researchers to Remotely Monitor Alcohol Use
University of North Texas, Denton, TX
NCT05641389
Anxiety During Abstinence in AUD
Columbia University
NCT06793488
Citicoline in Youth Alcohol Use Disorder
Medical University of South Carolina
NCT05870111
Semaglutide Therapy for Alcohol Reduction (STAR)
National Institute on Drug Abuse (NIDA)
NCT06015893
Drinking, Acetate, and Stress
Yale University
NCT06584448
Mobile Platform for Optimizing Wellness and Engagement in Recovery
University of Michigan
NCT07178990
Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)
University of Michigan
NCT07413458
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT06269627
Environment and Alcohol: A Pilot Study
National Institute on Drug Abuse (NIDA)
NCT06860607
Tirzepatide for Alcohol Use Disorder
University of Southern California
NCT06994338
Intranasal Insulin for Treatment of Alcohol Use Disorder
Brown University
NCT05988632
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
University of Rochester
NCT05943171
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
VA Palo Alto Health Care System
NCT06415721
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
University of Minnesota
NCT05062369
PT150 Drug for Use in Alcohol Use Disorder
Pop Test Oncology
NCT06712602
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
National Institute of Mental Health (NIMH)
NCT07027839
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
National Institute of Mental Health (NIMH)
NCT06795581
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
University of Pennsylvania
NCT06559995
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1
Yale University
NCT06004830
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2
Yale University
NCT06006143
CM for Patients With ALD After Liver Transplant
Arpan A. Patel, MD
NCT06304467
Suvorexant and Alcohol
William Stoops
NCT06326684
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 49 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Alcohol Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Alcohol Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Alcohol Use Disorder page
185 registered trials, 109 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 109 Alcohol Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Alcohol Use Disorder trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Alcohol Use Disorder condition card totals 185 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.