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ClinicalTrials.gov 109 recruiting now official registry

Alcohol Use Disorder clinical trials

109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.

185 US clinical trials · 109 currently recruiting

Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.

The research picture

Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.

109
recruiting participants now
59%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
13
top sponsor: Yale University
Phase 126Phase 249Phase 35Phase 43

Active & Recent Trials

185 total, page 2 of 4

RECRUITING NA 144 participants

The STop UNhealthy Substance Use Now Trial

Ohio State University

NCT06524232

RECRUITING Phase 2 144 participants

Neural Correlates During Alcohol Intoxication

Ohio State University

NCT06118580

RECRUITING NA 140 participants

Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

Medical University of South Carolina

NCT05786157

RECRUITING NA 125 participants

Automated Reinforcement Management Systems, Phase II

Washington State University

NCT06456905

RECRUITING NA 122 participants

Cerebellar Involvement in Alcohol Use Disorder (AUD)

Johns Hopkins University

NCT05732207

RECRUITING NA 120 participants

Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention

Shirish S Barve

NCT06005298

RECRUITING NA 104 participants

StuDy AimED at Increasing AlCohol AbsTinEnce

University of Illinois at Chicago

NCT05778734

RECRUITING NA 100 participants

Neural and Hormonal Influences on Sex Differences in Risk for AUD

Jessica Weafer

NCT04929288

RECRUITING NA 100 participants

Amplification of Positivity for Alcohol Use

Laureate Institute for Brain Research

NCT06030154

RECRUITING Early Phase 1 100 participants

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

Yale University

NCT05957159

RECRUITING Phase 4 100 participants

Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

Milky Kohno

NCT06426303

RECRUITING NA 100 participants

Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study

University of Texas at Austin

NCT05838274

RECRUITING NA 90 participants

Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

Yale University

NCT06489782

RECRUITING NA 90 participants

Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function

University of Oregon

NCT05684094

RECRUITING NA 90 participants

A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder

Auburn University

NCT05621538

RECRUITING NA 86 participants

MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

Medical University of South Carolina

NCT04998916

RECRUITING Phase 2 80 participants

Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial

University of Iowa

NCT06405607

RECRUITING NA 80 participants

Neuromodulation and Cognitive Training for Substance Use Disorders

University of Minnesota

NCT04426214

RECRUITING NA 80 participants

Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder

VA Office of Research and Development

NCT06399653

RECRUITING NA 80 participants

rTMS as Add on Treatment for Substance Use Disorders

Yale University

NCT06963476

RECRUITING Phase 1 80 participants

Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease

Virginia Commonwealth University

NCT05548452

RECRUITING NA 80 participants

Evaluating a One-Year Version of the Parent-Child Assistance Program

University of Oklahoma

NCT06163651

RECRUITING Phase 2 75 participants

A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol

The Mind Research Network

NCT04770025

RECRUITING 72 participants

The Impact of Heavy Alcohol Use on Saliva and Oral Health

National Institutes of Health Clinical Center (CC)

NCT06684483

RECRUITING Phase 2 62 participants

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

University of Colorado, Denver

NCT03904498

RECRUITING Phase 4 60 participants

Naltrexone in AUD Reward Drinkers

University of Pennsylvania

NCT05028062

RECRUITING Phase 2 60 participants

LGG Supplementation in Patients With AUD and ALD

University of Louisville

NCT05178069

RECRUITING NA 60 participants

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

University of Notre Dame

NCT07342504

RECRUITING 60 participants

Improving Remote Breathalyzer Procedures Used by Clinicians and Researchers to Remotely Monitor Alcohol Use

University of North Texas, Denton, TX

NCT05641389

RECRUITING Early Phase 1 60 participants

Anxiety During Abstinence in AUD

Columbia University

NCT06793488

RECRUITING Phase 2 56 participants

Citicoline in Youth Alcohol Use Disorder

Medical University of South Carolina

NCT05870111

RECRUITING Phase 2 52 participants

Semaglutide Therapy for Alcohol Reduction (STAR)

National Institute on Drug Abuse (NIDA)

NCT06015893

RECRUITING NA 50 participants

Drinking, Acetate, and Stress

Yale University

NCT06584448

RECRUITING NA 50 participants

Mobile Platform for Optimizing Wellness and Engagement in Recovery

University of Michigan

NCT07178990

RECRUITING NA 50 participants

Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)

University of Michigan

NCT07413458

RECRUITING Phase 4 48 participants

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT06269627

RECRUITING Phase 1 44 participants

Environment and Alcohol: A Pilot Study

National Institute on Drug Abuse (NIDA)

NCT06860607

RECRUITING Phase 2 42 participants

Tirzepatide for Alcohol Use Disorder

University of Southern California

NCT06994338

RECRUITING Phase 1 40 participants

Intranasal Insulin for Treatment of Alcohol Use Disorder

Brown University

NCT05988632

RECRUITING NA 40 participants

A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT

University of Rochester

NCT05943171

RECRUITING NA 40 participants

Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

VA Palo Alto Health Care System

NCT06415721

RECRUITING NA 40 participants

Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

University of Minnesota

NCT05062369

RECRUITING Phase 1 34 participants

PT150 Drug for Use in Alcohol Use Disorder

Pop Test Oncology

NCT06712602

RECRUITING Phase 1 30 participants

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

National Institute of Mental Health (NIMH)

NCT07027839

RECRUITING Phase 1 30 participants

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

National Institute of Mental Health (NIMH)

NCT06795581

RECRUITING Phase 2 30 participants

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

University of Pennsylvania

NCT06559995

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1

Yale University

NCT06004830

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

Yale University

NCT06006143

RECRUITING NA 30 participants

CM for Patients With ALD After Liver Transplant

Arpan A. Patel, MD

NCT06304467

RECRUITING Early Phase 1 30 participants

Suvorexant and Alcohol

William Stoops

NCT06326684

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 49
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcohol Use Disorder Trial Landscape

185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).

Phase mix: 8 late (III/IV) vs 75 early (I/II).

Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcohol Use Disorder?

PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcohol Use Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.