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NCT04929288 · ClinicalTrials.gov registry record · NA
Neural and Hormonal Influences on Sex Differences in Risk for AUD
A NA study of Alcohol Use Disorder, sponsored by Jessica Weafer.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT04929288: Recruiting NA study of Alcohol Use Disorder, sponsored by Jessica Weafer.
NCT04929288 is a NA study of Alcohol Use Disorder that is actively recruiting participants, run by Jessica Weafer. The registered enrollment target is 100 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (70% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04929288, a NA study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Jessica Weafer.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The sex gap in alcohol consumption is closing rapidly, due to alarming increases among women. From 2002-2013, Alcohol Use Disorder (AUD) increased 84% for women, compared to 35% for men. As such, there is an urgent need to determine the factors underlying sex differences in risk for AUD. Current addiction models propose three domains that drive problematic alcohol use and serve as candidate sex-specific risk factors: executive function, negative emotionality, and incentive salience. Data suggest that poor inhibitory control, a key component of executive function, is a stronger risk factor for women than for men. Moreover, there is have preliminary evidence that female drinkers show less engagement of neural inhibitory circuitry, and that this sex difference is influenced by estradiol. However, the degree to which hormonally-moderated sex differences in executive function extend to the negative emotionality and incentive salience domains, and how these sex differences influence current and future drinking is unknown. The goal of this study is to identify the mechanisms underlying sex-specific risk for AUD, and ultimately to help develop sex-specific prevention and treatment efforts. The overall objective of this trial is to determine the neural and hormonal factors contributing to sex-specific risk for AUD in three addiction domains: inhibitory control (executive function), negative emotionality, and alcohol cue reactivity (incentive salience).
Primary Outcome
One measure of neural inhibitory function during performance of the stop signal task will be activity (as measured by BOLD % signal change)
Conditions Studied
Interventions
- DRUG Alcohol
Study Locations (1)
Ohio
- The Ohio State University - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-05-11 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT04929288 shows while recruiting
NCT04929288 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (70% lower).
The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which Alcohol is the first listed.
NCT04929288 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04929288 about?
NCT04929288 is a clinical study titled "Neural and Hormonal Influences on Sex Differences in Risk for AUD". The sex gap in alcohol consumption is closing rapidly, due to alarming increases among women. From 2002-2013, Alcohol Use Disorder (AUD) increased 84% for women, compared to 35% for men. As such, there is an urgent need to determine the factors underlying sex differences in risk for AUD. Current add...
What is the current status of trial NCT04929288?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2021-05-11. Estimated completion is 2027-06-30.
What conditions does trial NCT04929288 study?
This clinical trial studies the following conditions: Alcohol Use Disorder.
What interventions are being tested in trial NCT04929288?
The interventions under investigation include: Alcohol (DRUG).
Who is sponsoring clinical trial NCT04929288?
This trial is sponsored by Jessica Weafer, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04929288 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04929288's enrollment target sits among peer trials
100 81st of 184 higher than 99 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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