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NCT06584448 · ClinicalTrials.gov registry record · NA
Drinking, Acetate, and Stress
A NA study of Alcohol Use Disorder and Alcohol Use, Unspecified, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 2
- Study locations
NCT06584448: Recruiting NA study of Alcohol Use Disorder and Alcohol Use, Unspecified, sponsored by Yale University.
NCT06584448 is a NA study of Alcohol Use Disorder and Alcohol Use, Unspecified that is actively recruiting participants, run by Yale University. The registered enrollment target is 50 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (85% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06584448, a NA study of Alcohol Use Disorder and Alcohol Use, Unspecified, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.
Primary Outcome
DMI data will be acquired during infusions of 2H-labeled Ac, using a 4-Tesla magnet. Deuterium flow from \[2,2,2-2H3\]Ac to glutamate (Glu) and glutamine (Gln). Ac forms AcetylCoA at a rate CMRAc and is oxidized by astroglia (VtcaA), labeling the small glial Glu pool (5-10% of the total Glu110).Astroglial Glu is converted to Gln and sent to neurons (Vcycle), where it is converted to labeled Glu. It mixes with the large neuronal Glu pool, fed also by unlabeled carbon mostly from glucose via neuro
Conditions Studied
Interventions
- OTHER Deuterium Metabolic Imaging with deuterated acetate tracer
Study Locations (2)
Connecticut
- The Anlyan Center, 300 Cedar St. - New Haven
- Yale University - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-11-06 |
| Est. Completion | 2030-01 |
| Phase | NA |
What NCT06584448 shows while recruiting
NCT06584448 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (85% lower).
The record links to 4 conditions, with Alcohol Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which Deuterium Metabolic Imaging with deuterated acetate tracer is the first listed.
NCT06584448 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06584448 about?
NCT06584448 is a clinical study titled "Drinking, Acetate, and Stress". The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results wi...
What is the current status of trial NCT06584448?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2024-11-06. Estimated completion is 2030-01.
What conditions does trial NCT06584448 study?
This clinical trial studies the following conditions: Alcohol Use Disorder, Alcohol Use, Unspecified, Heavy Drinker, Alcohol Use Disorder, Moderate, in Sustained Remission.
What interventions are being tested in trial NCT06584448?
The interventions under investigation include: Deuterium Metabolic Imaging with deuterated acetate tracer (OTHER).
Who is sponsoring clinical trial NCT06584448?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06584448 being conducted?
This trial has 2 study locations across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06584448's enrollment target sits among peer trials
50 125th of 184 higher than 57 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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