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ClinicalTrials.gov 109 recruiting now official registry

Alcohol Use Disorder clinical trials

109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.

185 US clinical trials · 109 currently recruiting

Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.

The research picture

Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.

109
recruiting participants now
59%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
13
top sponsor: Yale University
Phase 126Phase 249Phase 35Phase 43

Active & Recent Trials

185 total, page 3 of 4

RECRUITING NA 30 participants

Piloting a Deaf Accessible Pre-Treatment for AUD

University of Massachusetts, Worcester

NCT07269119

RECRUITING NA 25 participants

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

University of California, San Francisco

NCT06518785

RECRUITING NA 21 participants

Enhancing Prospective Thinking in Early Recovery (BEAM)

Indiana University

NCT06283472

RECRUITING Phase 2 20 participants

Ketone Ester Intervention in Alcohol Use Disorder

University of Pennsylvania

NCT04616781

RECRUITING NA 20 participants

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

Rush University Medical Center

NCT06139224

RECRUITING Phase 1 20 participants

Spironolactone in Alcohol Use Disorder (SAUD)

National Institute on Drug Abuse (NIDA)

NCT05807139

RECRUITING Phase 2 18 participants

MDMA for AUD/PTSD Comorbidity

Carolina L Haass-Koffler

NCT05943665

RECRUITING Phase 1 15 participants

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

University of Rochester

NCT06319872

RECRUITING NA 10 participants

Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study

Wake Forest University Health Sciences

NCT06770556

ACTIVE NOT RECRUITING Early Phase 1 782 participants

Behavioral Alcohol Responses (BAR) Study

Carnegie Mellon University

NCT03467191

ACTIVE NOT RECRUITING 733 participants

Long-term Recovery: Longitudinal Study of Neuro-behavioral Markers of Recovery and Precipitants of Relapse

Virginia Polytechnic Institute and State University

NCT04788004

ACTIVE NOT RECRUITING NA 470 participants

TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study

University of New Mexi

NCT06074341

ACTIVE NOT RECRUITING NA 250 participants

Clinical Course of Alcohol Use Disorder Recovery

University of South Florida

NCT05607290

ACTIVE NOT RECRUITING NA 220 participants

A Hybrid Effectiveness Implementation Study of Latino/a Alcohol and Drug Users

Boston University Charles River Campus

NCT04771650

ACTIVE NOT RECRUITING NA 211 participants

Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 1

Mikhail N Koffarnus

NCT03883126

ACTIVE NOT RECRUITING Phase 2 200 participants

Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder

Imbrium Therapeutics

NCT06545916

ACTIVE NOT RECRUITING NA 180 participants

Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use

University of California, San Francisco

NCT05191446

ACTIVE NOT RECRUITING NA 137 participants

Black Church Treatment Study

NYU Langone Health

NCT04580810

ACTIVE NOT RECRUITING NA 135 participants

Telehealth Treatment for Alcohol Use Disorder

Ria Health

NCT05747703

ACTIVE NOT RECRUITING NA 134 participants

Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)

University of Michigan

NCT04457674

ACTIVE NOT RECRUITING NA 91 participants

Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 2

Mikhail N Koffarnus

NCT03942770

ACTIVE NOT RECRUITING Phase 2 90 participants

Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder

Johns Hopkins University

NCT04620759

ACTIVE NOT RECRUITING NA 87 participants

Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk

NYU Langone Health

NCT05828849

ACTIVE NOT RECRUITING NA 80 participants

Alcoholic Liver Disease and the Gut Microbiome

University of California, Los Angeles

NCT05007470

ACTIVE NOT RECRUITING NA 60 participants

EMA/EMI for Psychiatrically Hospitalized Emerging Adults Who Drink to Cope

Butler Hospital

NCT05074030

ACTIVE NOT RECRUITING NA 60 participants

Early Intervention Following Sexual Assault

Medical University of South Carolina

NCT04582695

ACTIVE NOT RECRUITING NA 42 participants

Improving Care for Unhealthy Alcohol Use in Primary Care

VA Office of Research and Development

NCT04565899

ACTIVE NOT RECRUITING NA 40 participants

Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder

Louisiana State University Health Sciences Center in New Orleans

NCT05902754

ACTIVE NOT RECRUITING NA 40 participants

Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)

Mayo Clinic

NCT06319222

ACTIVE NOT RECRUITING Phase 1 35 participants

rTMS in Older Adults With MCI and AUD

Medical University of South Carolina

NCT05896332

ACTIVE NOT RECRUITING Phase 1 25 participants

Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder

Yale University

NCT05223829

ACTIVE NOT RECRUITING 20 participants

Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism

Healing Advocacy Fund

NCT07189988

ACTIVE NOT RECRUITING Phase 2 20 participants

Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder

Peggy C Nopoulos

NCT05421065

ACTIVE NOT RECRUITING Phase 2 20 participants

Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder

Keith Heinzerling

NCT04410913

ACTIVE NOT RECRUITING Early Phase 1 12 participants

Diclofenac as a KMO Inhibitor

University of Maryland, Baltimore

NCT06029296

ACTIVE NOT RECRUITING Phase 1 10 participants

Apremilast for Alcohol Use Disorder Treatment in Women and Men

Yale University

NCT06324435

ACTIVE NOT RECRUITING Early Phase 1 4 participants

Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study

University of Pennsylvania

NCT05885594

ACTIVE NOT RECRUITING Phase 2 1 participants

Pilot rTMS for AUD+mTBI

VA Office of Research and Development

NCT03995173

COMPLETED NA 13,680 participants

Screening and Management of Unhealthy Alcohol Use in Primary Care

Virginia Commonwealth University

NCT04248023

COMPLETED NA 488 participants

Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)

University of Michigan

NCT04488055

COMPLETED NA 399 participants

Facilitating Alcohol Screening and Treatment (FAST)

University of Colorado, Denver

NCT04303676

COMPLETED NA 398 participants

Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19

University of Wisconsin, Madison

NCT05419128

COMPLETED Phase 2 346 participants

HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use Disorder

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02252536

COMPLETED Phase 2 192 participants

Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)

Medical University of South Carolina

NCT03846505

COMPLETED NA 164 participants

Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers

New York State Psychiatric Institute

NCT03457077

COMPLETED Phase 3 156 participants

Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action

Virginia Commonwealth University

NCT02900352

COMPLETED NA 146 participants

Alcohol and Cannabis Concentrates Co-Administration

University of Colorado, Denver

NCT05999344

COMPLETED Phase 2 120 participants

Addressing Heavy Alcohol Use Consumption With Kudzu

Glenn-Milo Santos

NCT03709043

COMPLETED NA 114 participants

CM Treatment for Alcohol Dependence Using New Technology

UConn Health

NCT02143037

COMPLETED Phase 2 102 participants

Ibudilast for the Treatment of Alcohol Use Disorder

University of California, Los Angeles

NCT03594435

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 49
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcohol Use Disorder Trial Landscape

185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).

Phase mix: 8 late (III/IV) vs 75 early (I/II).

Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcohol Use Disorder?

PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcohol Use Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.