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Alcohol Use Disorder clinical trials
109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.
185 US clinical trials · 109 currently recruiting
Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.
The research picture
Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.
- 109
- recruiting participants now
- 59%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Yale University
Active & Recent Trials
185 total, page 3 of 4
Piloting a Deaf Accessible Pre-Treatment for AUD
University of Massachusetts, Worcester
NCT07269119
Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder
University of California, San Francisco
NCT06518785
Enhancing Prospective Thinking in Early Recovery (BEAM)
Indiana University
NCT06283472
Ketone Ester Intervention in Alcohol Use Disorder
University of Pennsylvania
NCT04616781
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Rush University Medical Center
NCT06139224
Spironolactone in Alcohol Use Disorder (SAUD)
National Institute on Drug Abuse (NIDA)
NCT05807139
MDMA for AUD/PTSD Comorbidity
Carolina L Haass-Koffler
NCT05943665
The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
University of Rochester
NCT06319872
Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
Wake Forest University Health Sciences
NCT06770556
Behavioral Alcohol Responses (BAR) Study
Carnegie Mellon University
NCT03467191
Long-term Recovery: Longitudinal Study of Neuro-behavioral Markers of Recovery and Precipitants of Relapse
Virginia Polytechnic Institute and State University
NCT04788004
TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study
University of New Mexi
NCT06074341
Clinical Course of Alcohol Use Disorder Recovery
University of South Florida
NCT05607290
A Hybrid Effectiveness Implementation Study of Latino/a Alcohol and Drug Users
Boston University Charles River Campus
NCT04771650
Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 1
Mikhail N Koffarnus
NCT03883126
Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder
Imbrium Therapeutics
NCT06545916
Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
University of California, San Francisco
NCT05191446
Black Church Treatment Study
NYU Langone Health
NCT04580810
Telehealth Treatment for Alcohol Use Disorder
Ria Health
NCT05747703
Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)
University of Michigan
NCT04457674
Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 2
Mikhail N Koffarnus
NCT03942770
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Johns Hopkins University
NCT04620759
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
NYU Langone Health
NCT05828849
Alcoholic Liver Disease and the Gut Microbiome
University of California, Los Angeles
NCT05007470
EMA/EMI for Psychiatrically Hospitalized Emerging Adults Who Drink to Cope
Butler Hospital
NCT05074030
Early Intervention Following Sexual Assault
Medical University of South Carolina
NCT04582695
Improving Care for Unhealthy Alcohol Use in Primary Care
VA Office of Research and Development
NCT04565899
Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
Louisiana State University Health Sciences Center in New Orleans
NCT05902754
Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)
Mayo Clinic
NCT06319222
rTMS in Older Adults With MCI and AUD
Medical University of South Carolina
NCT05896332
Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder
Yale University
NCT05223829
Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism
Healing Advocacy Fund
NCT07189988
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
Peggy C Nopoulos
NCT05421065
Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder
Keith Heinzerling
NCT04410913
Diclofenac as a KMO Inhibitor
University of Maryland, Baltimore
NCT06029296
Apremilast for Alcohol Use Disorder Treatment in Women and Men
Yale University
NCT06324435
Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study
University of Pennsylvania
NCT05885594
Pilot rTMS for AUD+mTBI
VA Office of Research and Development
NCT03995173
Screening and Management of Unhealthy Alcohol Use in Primary Care
Virginia Commonwealth University
NCT04248023
Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)
University of Michigan
NCT04488055
Facilitating Alcohol Screening and Treatment (FAST)
University of Colorado, Denver
NCT04303676
Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19
University of Wisconsin, Madison
NCT05419128
HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use Disorder
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT02252536
Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
Medical University of South Carolina
NCT03846505
Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers
New York State Psychiatric Institute
NCT03457077
Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action
Virginia Commonwealth University
NCT02900352
Alcohol and Cannabis Concentrates Co-Administration
University of Colorado, Denver
NCT05999344
Addressing Heavy Alcohol Use Consumption With Kudzu
Glenn-Milo Santos
NCT03709043
CM Treatment for Alcohol Dependence Using New Technology
UConn Health
NCT02143037
Ibudilast for the Treatment of Alcohol Use Disorder
University of California, Los Angeles
NCT03594435
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 49 |
| Phase 3 | 5 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alcohol Use Disorder Trial Landscape
185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).
Phase mix: 8 late (III/IV) vs 75 early (I/II).
Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alcohol Use Disorder?
PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alcohol Use Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.