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NCT05988632 · ClinicalTrials.gov registry record · Phase 1
Intranasal Insulin for Treatment of Alcohol Use Disorder
A Phase 1 study of Alcohol Use Disorder, sponsored by Brown University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05988632: Recruiting Phase 1 study of Alcohol Use Disorder, sponsored by Brown University.
NCT05988632 is a Phase 1 study of Alcohol Use Disorder that is actively recruiting participants, run by Brown University. The registered enrollment target is 40 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05988632, a Phase 1 study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Brown University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a single dose of IN insulin (80IU) or an IN matched placebo (0.9% Saline). Participants will undergo a cue-reactivity paradigm followed by an alcohol challenge that includes an alcohol drink designed to raise the breath alcohol content (BrAC) to 0.08g/dL.
Primary Outcome
Adverse event reported during the drug administration
Conditions Studied
Interventions
- DRUG Regular Human Insulin then Placebo
- DRUG Placebo then Regular Human Insulin
Study Locations (1)
Rhode Island
- Brown University - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-02-25 |
| Est. Completion | 2027-01-31 |
| Phase | Phase 1 |
What NCT05988632 shows while recruiting
NCT05988632 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Regular Human Insulin then Placebo is the first listed.
NCT05988632 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT05988632 about?
NCT05988632 is a clinical study titled "Intranasal Insulin for Treatment of Alcohol Use Disorder". This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a si...
What is the current status of trial NCT05988632?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-02-25. Estimated completion is 2027-01-31.
What conditions does trial NCT05988632 study?
This clinical trial studies the following conditions: Alcohol Use Disorder.
What interventions are being tested in trial NCT05988632?
The interventions under investigation include: Regular Human Insulin then Placebo (DRUG), Placebo then Regular Human Insulin (DRUG).
Who is sponsoring clinical trial NCT05988632?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05988632 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05988632's enrollment target sits among peer trials
40 138th of 184 higher than 40 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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