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NCT05988632 · ClinicalTrials.gov registry record · Phase 1

Intranasal Insulin for Treatment of Alcohol Use Disorder

A Phase 1 study of Alcohol Use Disorder, sponsored by Brown University.

Recruiting
Registry status
Phase 1
Development phase
40
Enrollment target
1
Study location

NCT05988632 is a Phase 1 study of Alcohol Use Disorder that is actively recruiting participants, run by Brown University. The registered enrollment target is 40 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05988632, a Phase 1 study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Brown University.

RECRUITING
Registry status
Phase 1
Development phase
40 participants
Enrollment target
1
Study location

Study Summary

This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a single dose of IN insulin (80IU) or an IN matched placebo (0.9% Saline). Participants will undergo a cue-reactivity paradigm followed by an alcohol challenge that includes an alcohol drink designed to raise the breath alcohol content (BrAC) to 0.08g/dL.

Conditions Studied

Alcohol Use Disorder

Interventions

  • DRUG Regular Human Insulin then Placebo
  • DRUG Placebo then Regular Human Insulin

Study Locations (1)

Rhode Island

  • Brown University - Providence

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2025-02-25
Est. Completion 2027-01-31
Phase Phase 1

Sponsor

Brown University

231 total trials

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What the Registry Record Tells You About NCT05988632

The ClinicalTrials.gov registry entry for NCT05988632 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower). The listed sponsor is Brown University, which has 231 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Regular Human Insulin then Placebo is the first listed.

NCT05988632 reports 1 study location spanning 1 distinct geographic area - top geographies include Rhode Island.

Frequently Asked Questions

What is clinical trial NCT05988632 about?

NCT05988632 is a clinical study titled "Intranasal Insulin for Treatment of Alcohol Use Disorder". This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a si...

What is the current status of trial NCT05988632?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-02-25. Estimated completion is 2027-01-31.

What conditions does trial NCT05988632 study?

This clinical trial studies the following conditions: Alcohol Use Disorder.

What interventions are being tested in trial NCT05988632?

The interventions under investigation include: Regular Human Insulin then Placebo (DRUG), Placebo then Regular Human Insulin (DRUG).

Who is sponsoring clinical trial NCT05988632?

This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05988632 being conducted?

This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.