National Institute on Alcohol Abuse and Alcoholism (NIAAA)

93 total trials 16 currently recruiting 71 completed

National Institute on Alcohol Abuse and Alcoholism (NIAAA) sponsors 93 registered US clinical trials on ClinicalTrials.gov, 16 of them currently recruiting, and 71 completed. 9 of these trials are in Phase 3-4 (later-stage) and 58 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Alcoholism, with 11 trials.

Trial Pipeline

93 total, page 1 of 2

RECRUITING Phase 2

Tirzepatide in MetALD

NCT07046819

RECRUITING Phase 1

Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)

NCT07559500

RECRUITING Phase 2

Human Laboratory Study of Apremilast for Alcohol Use Disorder

NCT07325266

RECRUITING Phase 1

Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors

NCT06819189

RECRUITING Phase 4

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

NCT06269627

RECRUITING Phase 1

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

NCT06484075

RECRUITING

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

NCT05677321

RECRUITING

Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

NCT04714892

RECRUITING Phase 1

Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers

NCT04781322

RECRUITING

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

NCT04391816

RECRUITING Phase 1

Nicotinic Receptor Genetic Variation and Alcohol Reward

NCT03294460

RECRUITING Phase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

NCT03407079

RECRUITING NA

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

NCT02535702

RECRUITING

NIAAA Natural History Protocol

NCT02231840

RECRUITING

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

NCT02108080

RECRUITING NA

Behavioral and Functional Task Development, Implementation, and Testing

NCT02108054

COMPLETED Phase 2

Intranasal Oxytocin for the Treatment of Alcohol Use Disorder

NCT03878316

COMPLETED Phase 2

Human Laboratory Study of ASP8062 for Alcohol Use Disorder

NCT05096117

COMPLETED Phase 1

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

NCT04360018

TERMINATED Phase 2

HLAB-002 of ANS-6637 for Alcohol Use Disorder

NCT03970109

COMPLETED Phase 1

Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

NCT03326245

COMPLETED NA

Ketogenic Diet (KD) in Alcoholism

NCT03255031

COMPLETED Early Phase 1

Brain Dopaminergic Signaling in Opioid Use Disorders

NCT03190954

COMPLETED Phase 1

Human Laboratory Study of Varenicline for Alcohol Use Disorder

NCT03035708

TERMINATED Phase 2

A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part II

NCT02707055

COMPLETED Phase 1

Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation

NCT02639273

COMPLETED Early Phase 1

Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People

NCT02669225

COMPLETED

Study of Structural Imaging

NCT02564991

COMPLETED

Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence

NCT02438969

COMPLETED Early Phase 1

Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness

NCT02311374

COMPLETED Early Phase 1

Reliability of the Human Brain Connectome

NCT02193425

COMPLETED Phase 2

HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use Disorder

NCT02252536

COMPLETED Early Phase 1

Brain Inflammation and Function in Alcoholism

NCT02233868

COMPLETED

Neural Substrates of Approach-Avoidance Conflict

NCT02119624

TERMINATED Phase 2

Neuroimaging, Omega-3 and Reward in Adults With ADHD (NORAA) Trial

NCT02156089

COMPLETED Phase 1

A Novel Compound for Alcoholism Treatment

NCT02039349

COMPLETED Phase 2

Genetic Effects on Dopamine Response to an Opiate

NCT01878006

COMPLETED Phase 2

ABT-436 for Alcohol Dependence

NCT01613014

COMPLETED Phase 2

Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers

NCT01779024

COMPLETED Phase 2

Baclofen for Treating Anxiety and Alcoholism

NCT01751386

TERMINATED Phase 2

Role of Proinflammatory Signaling in Alcohol Craving

NCT01631630

TERMINATED

Measuring Effects of Alcohol on Brain Chemistry

NCT01492933

TERMINATED Phase 1

Genetics of the Acute Response to Alcohol in Social Drinkers

NCT01375556

COMPLETED Phase 2

Varenicline for Alcohol Dependence

NCT01146613

COMPLETED

National Epidemiologic Survey on Alcohol and Related Conditions-III

NCT01273220

COMPLETED NA

Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition

NCT01251887

COMPLETED Phase 2

Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^

NCT01227980

COMPLETED Phase 2

CRF1 Antagonist GSK561679 in Alcoholism

NCT01187511

COMPLETED Phase 2

Levetiracetam XR in Very Heavy Drinkers

NCT00970814

COMPLETED Phase 2

The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSD

NCT00896038

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Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 37
Phase 3 1
Phase 4 8

What the Pipeline for National Institute on Alcohol Abuse and Alcoholism (NIAAA) Shows

According to the ClinicalTrials.gov registry, National Institute on Alcohol Abuse and Alcoholism (NIAAA) is linked to 93 US clinical trials across every stage of research activity. Of those, 16 studies are currently recruiting, about 17% of the sponsor's indexed portfolio, and 71 are already marked complete, representing roughly 76% of the total.

The phase mix for National Institute on Alcohol Abuse and Alcoholism (NIAAA) reports 9 late-stage studies (Phase 3 and Phase 4 combined) and 58 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute on Alcohol Abuse and Alcoholism (NIAAA) is Alcoholism with 11 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.