National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA) sponsors 93 registered US clinical trials on ClinicalTrials.gov, 16 of them currently recruiting, and 71 completed. 9 of these trials are in Phase 3-4 (later-stage) and 58 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Alcoholism, with 11 trials.
Trial Pipeline
93 total, page 1 of 2
Tirzepatide in MetALD
NCT07046819
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
NCT07559500
Human Laboratory Study of Apremilast for Alcohol Use Disorder
NCT07325266
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors
NCT06819189
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
NCT06269627
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
NCT06484075
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
NCT05677321
Mechanisms Underlying Individual Variations of Taste and Smell in Obesity
NCT04714892
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
NCT04781322
COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study
NCT04391816
Nicotinic Receptor Genetic Variation and Alcohol Reward
NCT03294460
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
NCT03407079
Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
NCT02535702
NIAAA Natural History Protocol
NCT02231840
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
NCT02108080
Behavioral and Functional Task Development, Implementation, and Testing
NCT02108054
Intranasal Oxytocin for the Treatment of Alcohol Use Disorder
NCT03878316
Human Laboratory Study of ASP8062 for Alcohol Use Disorder
NCT05096117
Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors
NCT04360018
HLAB-002 of ANS-6637 for Alcohol Use Disorder
NCT03970109
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI
NCT03326245
Ketogenic Diet (KD) in Alcoholism
NCT03255031
Brain Dopaminergic Signaling in Opioid Use Disorders
NCT03190954
Human Laboratory Study of Varenicline for Alcohol Use Disorder
NCT03035708
A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part II
NCT02707055
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation
NCT02639273
Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People
NCT02669225
Study of Structural Imaging
NCT02564991
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
NCT02438969
Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness
NCT02311374
Reliability of the Human Brain Connectome
NCT02193425
HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use Disorder
NCT02252536
Brain Inflammation and Function in Alcoholism
NCT02233868
Neural Substrates of Approach-Avoidance Conflict
NCT02119624
Neuroimaging, Omega-3 and Reward in Adults With ADHD (NORAA) Trial
NCT02156089
A Novel Compound for Alcoholism Treatment
NCT02039349
Genetic Effects on Dopamine Response to an Opiate
NCT01878006
ABT-436 for Alcohol Dependence
NCT01613014
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers
NCT01779024
Baclofen for Treating Anxiety and Alcoholism
NCT01751386
Role of Proinflammatory Signaling in Alcohol Craving
NCT01631630
Measuring Effects of Alcohol on Brain Chemistry
NCT01492933
Genetics of the Acute Response to Alcohol in Social Drinkers
NCT01375556
Varenicline for Alcohol Dependence
NCT01146613
National Epidemiologic Survey on Alcohol and Related Conditions-III
NCT01273220
Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition
NCT01251887
Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^
NCT01227980
CRF1 Antagonist GSK561679 in Alcoholism
NCT01187511
Levetiracetam XR in Very Heavy Drinkers
NCT00970814
The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSD
NCT00896038
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 37 |
| Phase 3 | 1 |
| Phase 4 | 8 |
Therapeutic Areas
What the Pipeline for National Institute on Alcohol Abuse and Alcoholism (NIAAA) Shows
According to the ClinicalTrials.gov registry, National Institute on Alcohol Abuse and Alcoholism (NIAAA) is linked to 93 US clinical trials across every stage of research activity. Of those, 16 studies are currently recruiting, about 17% of the sponsor's indexed portfolio, and 71 are already marked complete, representing roughly 76% of the total.
The phase mix for National Institute on Alcohol Abuse and Alcoholism (NIAAA) reports 9 late-stage studies (Phase 3 and Phase 4 combined) and 58 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Institute on Alcohol Abuse and Alcoholism (NIAAA) is Alcoholism with 11 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.