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Smoking Cessation clinical trials
Every US clinical trial registered for Smoking Cessation — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
189 US clinical trials · 57 currently recruiting
The research picture
Smoking Cessation has 189 registered US clinical trials, 57 of them open to new participants right now — about 30% of the total.
- 57
- recruiting participants now
- 30%
- of trials open to enrollment
- 33
- in Phase 3–4 (later-stage)
- 10
- top sponsor: University of California, San Francis
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
CONNECT Cancer Survivors With Tobacco Treatment
Washington University School of Medicine
NCT07020273
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
Children's Hospital of Philadelphia
NCT06582693
Veteran Social Support for Enhancing Use of Smoking Cessation Treatment
VA Office of Research and Development
NCT05868421
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Weill Medical College of Cornell University
NCT01776398
Testing the mHealth App Intervention for Nondaily Smokers "SiS4"
Massachusetts General Hospital
NCT06678243
Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors
Northwestern University
NCT05687604
Family-Based Financial Incentives Intervention for Smoking Cessation
Mayo Clinic
NCT06556433
Tobacco Education and Lung Health Study (TEAL)
Georgetown University
NCT06290869
Bladder Cancer Screening Trial
University of Texas Southwestern Medical Center
NCT05646485
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Washington University School of Medicine
NCT05846841
Baby Steps III: Testing a Clinician and Patient Intervention to Promote Smoking Cessation Among Pregnant Women
Duke University
NCT04985903
Take A Break - Rural
Wake Forest University Health Sciences
NCT05790486
Overcoming Nicotine Dependence to Enable Quitting
Rush University Medical Center
NCT05513872
Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
University of Virginia
NCT05660525
Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities
University of California, San Francis
NCT07049757
Enhancing Smoking Cessation Via Telehealth Options in Primary Care
Medical University of South Carolina
NCT05493254
Smoking Cessation Program in the Construction Sector
University of Miami
NCT06098144
Urban and Reservation Implementation of All Nations Breath of Life
Lehigh University
NCT04931810
Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment
University of Kansas Medical Center
NCT05732272
The Avenues Study: Dual Use Cessation
University of Wisconsin, Madison
NCT06474299
Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care
New York University
NCT06598397
Technology Assisted Motivational Interviewing
University of California, San Francis
NCT06713603
Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study
Baystate Medical Center
NCT05733767
American Indian Smokefree Native RCT
Masonic Cancer Center, University of Minnesota
NCT06544811
Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
University of Rochester
NCT06926608
V+PSF-M for Tobacco Cessation in HIV Care in India
University of Colorado, Denver
NCT05786547
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
Wake Forest University Health Sciences
NCT06883097
The Options 2 Study
University of Wisconsin, Madison
NCT06595459
Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments
Medical University of South Carolina
NCT05764759
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
University of Minnesota
NCT04783857
Intervening to Promote Tobacco Cessation Following Psychiatric Hospitalization
University of Texas at Austin
NCT05672914
Wellness Intervention for Smoking and HIV
University of Arizona
NCT04725617
CONNECTing to LungCare
University of California, San Francis
NCT06213532
Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients
Washington University School of Medicine
NCT07166120
New Strategies to Enhance Smoking Cessation
University of Chicago
NCT06751927
Creation of an Infrastructure to Support Delivery of mHealth Interventions for Cancer Patients
H. Lee Moffitt Cancer Center and Research Institute
NCT06909357
Re-Connect Application for Smoking Cessation
Rowan University
NCT05224154
Quit-Smoking Study for Native Hawaiians
University of Hawaii
NCT07075575
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
University of California, Los Angeles
NCT06617312
Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy
Brown University
NCT06948058
ACT Lung Health Intervention: Phase Two
Dana-Farber Cancer Institute
NCT06945120
Remote Smoking Cessation in Hospitalized Cardiac Patients
University of Vermont Medical Center
NCT05738408
Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)
Southcentral Foundation
NCT06556238
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Medical University of South Carolina
NCT06678789
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
The University of Texas Health Science Center, Houston
NCT05276050
Mindfulness-based Ecological Momentary Intervention for Smoking Cessation Among Cancer Survivors
Rutgers, The State University of New Jersey
NCT07210567
Healing Within: Mindfulness Smoking Cessation Intervention
National Heart, Lung, and Blood Institute (NHLBI)
NCT07013968
Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Black Hills Center for American Indian Health
NCT06357767
Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study
Wake Forest University Health Sciences
NCT05460676
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
Yale University
NCT06027840
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
Stony Brook University
NCT05724810
Preliminary Effectiveness of Enhanced Text Message + Incentives
University of Kansas Medical Center
NCT07420621
A Culturally Tailored Smartphone Application for African American Smokers
University of Oklahoma
NCT05188287
Trauma-Informed Care for Smoking Cessation for Pregnancy
University of California, San Francis
NCT07129590
Contingency Management to Promote Smoking Cessation
University of Kansas Medical Center
NCT06456242
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Yale University
NCT07224087
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Evaluation of an "Opt-Out" Inpatient Smoking Cessation Service on Smoking Behavior Study #1
Medical University of South Carolina
NCT04827914
A Randomized Clinical Trial Assessing Smoking Cessation Interventions In Dental Clinic Smokers
Memorial Sloan Kettering Cancer Center
NCT00591175
Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites
Memorial Sloan Kettering Cancer Center
NCT03315910
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Automated Video-Assisted Smoking Treatment for People Living With HIV
H. Lee Moffitt Cancer Center and Research Institute
NCT05014282
Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer
M.D. Anderson Cancer Center
NCT03059940
Mobile Contingency Management for Smoking Cessation
University of Oklahoma
NCT04881630
Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers
H. Lee Moffitt Cancer Center and Research Institute
NCT05004662
Telephone All Nations Breath of Life
Lehigh University
NCT04764175
VR Smoking Cessation During a Dental Hygiene Visit
Boston University
NCT04524533
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)
H. Lee Moffitt Cancer Center and Research Institute
NCT05645146
Construal Level as a Novel Pathway for Affect Regulation and Cancer Control
University of Oregon
NCT04620915
Implementation of a System-level Tobacco Treatment Intervention
Dana-Farber Cancer Institute
NCT02816697
Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
Seattle Institute for Biomedical and Clinical Research
NCT04505371
Digitally Enhanced Smoking Cessation for High Risk Smokers
Dana-Farber Cancer Institute
NCT04691297
Smoking Cessation Treatment for Head & Neck Cancer Patients
M.D. Anderson Cancer Center
NCT01098955
Forward to Quit: A Person-centered Mobile Technology Intervention for Smoking Cessation Among Transgender Adults
University of Colorado, Denver
NCT07181551
Acceptability of Mobile Applications (Apps) to Enhance Smoking Cessation in a Clinical Tobacco Treatment Program - A Pilot Study
M.D. Anderson Cancer Center
NCT05038852
Randomized Clinical Trial to Reduce Harm From Tobacco
University of Pennsylvania
NCT02328794
Young Adult Smoker's Treatment Demand
University of Illinois at Chicago
NCT01569529
Latinos Kick Buts: Mobile Engagement and Cessation Support for Latinos Who Smoke
University of Rochester
NCT05722132
A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation
Pfizer
NCT00143286
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Facilitating Implementation of the PHS Smoking Cessation Guidelines - RESET
US Department of Veterans Affairs
NCT00057070
Dissemination of Tobacco Tactics for Hospitalized Smokers
University of Michigan
NCT01309217
Spanish-Language Smoking Cessation Trial
H. Lee Moffitt Cancer Center and Research Institute
NCT02945787
Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)
University of Tennessee
NCT00632411
Expert System and Family Assisted Interventions for Chinese Smokers
University of California, San Francis
NCT00714467
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
Medical University of South Carolina
NCT01509586
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
University of Wisconsin, Madison
NCT01553084
Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines
University of Wisconsin, Madison
NCT01087905
Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)
University of California, Irvine
NCT02823028
Computer-Facilitated 5A's for Smoking Cessation in Primary Care
University of California, San Francis
NCT02046408
Genetically Informed Smoking Cessation Trial
Washington University School of Medicine
NCT02351167
Disease Management for Smoking Cessation
University of Kansas Medical Center
NCT00440115
An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation
Pfizer
NCT00143325
Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking
Pfizer
NCT00282984
Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date
Pfizer
NCT00691483
Pharmacogenetics, Emotional Reactivity and Smoking
M.D. Anderson Cancer Center
NCT00507728
Combining Varenicline and Bupropion for Smoking Cessation
M.D. Anderson Cancer Center
NCT00943618
Connect to Quit for Smoking
University of Pittsburgh
NCT01299896
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype
Duke University
NCT00894166
Identifying Treatments to Motivate Smokers to Quit
University of Wisconsin, Madison
NCT01122238
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Cessation Trial Landscape
ClinicalTrials.gov lists 189 US studies indexed under Smoking Cessation, and 57 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Smoking Cessation shows 33 late-stage studies (Phase 3 and Phase 4 combined) alongside 30 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Smoking Cessation is led by University of California, San Francis with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking Cessation?
PlainTrial tracks 189 US clinical trials for Smoking Cessation, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking Cessation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.