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ClinicalTrials.gov 57 recruiting now official registry

Smoking Cessation clinical trials

57 of 189 indexed Smoking Cessation trials are currently recruiting.

189 US clinical trials · 57 currently recruiting

Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.

The research picture

Smoking Cessation has 189 registered US clinical trials, 57 of them open to new participants right now, about 30% of the total.

57
recruiting participants now
30%
of trials open to enrollment
33
in Phase 3–4 (later-stage)
10
top sponsor: University of California, San Francisco
Phase 115Phase 215Phase 314Phase 419

Active & Recent Trials

189 total, page 1 of 4

RECRUITING NA 5,000 participants

CONNECT Cancer Survivors With Tobacco Treatment

Washington University School of Medicine

NCT07020273

RECRUITING NA 3,200 participants

Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

Children's Hospital of Philadelphia

NCT06582693

RECRUITING NA 2,376 participants

Veteran Social Support for Enhancing Use of Smoking Cessation Treatment

VA Office of Research and Development

NCT05868421

RECRUITING 2,000 participants

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

Weill Medical College of Cornell University

NCT01776398

RECRUITING NA 1,600 participants

Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

Massachusetts General Hospital

NCT06678243

RECRUITING NA 1,500 participants

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

Northwestern University

NCT05687604

RECRUITING NA 1,312 participants

Family-Based Financial Incentives Intervention for Smoking Cessation

Mayo Clinic

NCT06556433

RECRUITING Phase 3 1,188 participants

Tobacco Education and Lung Health Study (TEAL)

Georgetown University

NCT06290869

RECRUITING NA 1,000 participants

Bladder Cancer Screening Trial

University of Texas Southwestern Medical Center

NCT05646485

RECRUITING NA 850 participants

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Washington University School of Medicine

NCT05846841

RECRUITING NA 840 participants

Baby Steps III: Testing a Clinician and Patient Intervention to Promote Smoking Cessation Among Pregnant Women

Duke University

NCT04985903

RECRUITING NA 800 participants

Take A Break - Rural

Wake Forest University Health Sciences

NCT05790486

RECRUITING Phase 1 780 participants

Overcoming Nicotine Dependence to Enable Quitting

Rush University Medical Center

NCT05513872

RECRUITING NA 768 participants

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

University of Virginia

NCT05660525

RECRUITING NA 760 participants

Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities

University of California, San Francisco

NCT07049757

RECRUITING NA 672 participants

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

Medical University of South Carolina

NCT05493254

RECRUITING Phase 4 608 participants

Smoking Cessation Program in the Construction Sector

University of Miami

NCT06098144

RECRUITING NA 576 participants

Urban and Reservation Implementation of All Nations Breath of Life

Lehigh University

NCT04931810

RECRUITING Phase 3 500 participants

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

University of Kansas Medical Center

NCT05732272

RECRUITING Phase 4 500 participants

The Avenues Study: Dual Use Cessation

University of Wisconsin, Madison

NCT06474299

RECRUITING Phase 4 500 participants

Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

New York University

NCT06598397

RECRUITING NA 440 participants

Technology Assisted Motivational Interviewing

University of California, San Francisco

NCT06713603

RECRUITING Phase 2 424 participants

Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study

Baystate Medical Center

NCT05733767

RECRUITING NA 416 participants

American Indian Smokefree Native RCT

Masonic Cancer Center, University of Minnesota

NCT06544811

RECRUITING NA 408 participants

Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

University of Rochester

NCT06926608

RECRUITING Phase 3 400 participants

V+PSF-M for Tobacco Cessation in HIV Care in India

University of Colorado, Denver

NCT05786547

RECRUITING NA 314 participants

Quitting Matters Human Immunodeficiency Virus Hybrid Trial

Wake Forest University Health Sciences

NCT06883097

RECRUITING Phase 4 300 participants

The Options 2 Study

University of Wisconsin, Madison

NCT06595459

RECRUITING NA 288 participants

Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments

Medical University of South Carolina

NCT05764759

RECRUITING Phase 4 279 participants

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

University of Minnesota

NCT04783857

RECRUITING NA 250 participants

Intervening to Promote Tobacco Cessation Following Psychiatric Hospitalization

University of Texas at Austin

NCT05672914

RECRUITING NA 200 participants

Wellness Intervention for Smoking and HIV

University of Arizona

NCT04725617

RECRUITING NA 147 participants

CONNECTing to LungCare

University of California, San Francisco

NCT06213532

RECRUITING NA 112 participants

Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

Washington University School of Medicine

NCT07166120

RECRUITING NA 94 participants

New Strategies to Enhance Smoking Cessation

University of Chicago

NCT06751927

RECRUITING NA 90 participants

Creation of an Infrastructure to Support Delivery of mHealth Interventions for Cancer Patients

H. Lee Moffitt Cancer Center and Research Institute

NCT06909357

RECRUITING NA 82 participants

Re-Connect Application for Smoking Cessation

Rowan University

NCT05224154

RECRUITING NA 75 participants

Quit-Smoking Study for Native Hawaiians

University of Hawaii

NCT07075575

RECRUITING Phase 2 64 participants

Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity

University of California, Los Angeles

NCT06617312

RECRUITING NA 60 participants

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Brown University

NCT06948058

RECRUITING NA 50 participants

ACT Lung Health Intervention: Phase Two

Dana-Farber Cancer Institute

NCT06945120

RECRUITING NA 50 participants

Remote Smoking Cessation in Hospitalized Cardiac Patients

University of Vermont Medical Center

NCT05738408

RECRUITING NA 50 participants

Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)

Southcentral Foundation

NCT06556238

RECRUITING NA 50 participants

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

Medical University of South Carolina

NCT06678789

RECRUITING NA 50 participants

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

The University of Texas Health Science Center, Houston

NCT05276050

RECRUITING NA 50 participants

Mindfulness-based Ecological Momentary Intervention for Smoking Cessation Among Cancer Survivors

Rutgers, The State University of New Jersey

NCT07210567

RECRUITING NA 48 participants

Healing Within: Mindfulness Smoking Cessation Intervention

National Heart, Lung, and Blood Institute (NHLBI)

NCT07013968

RECRUITING NA 48 participants

Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence

Black Hills Center for American Indian Health

NCT06357767

RECRUITING NA 46 participants

Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study

Wake Forest University Health Sciences

NCT05460676

RECRUITING Phase 1 40 participants

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

Yale University

NCT06027840

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 15
Phase 3 14
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoking Cessation Trial Landscape

189 indexed Smoking Cessation studies · 57 recruiting (30%).

Phase mix: 33 late (III/IV) vs 30 early (I/II).

Top sponsor: University of California, San Francisco (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoking Cessation?

PlainTrial tracks 189 US clinical trials for Smoking Cessation, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoking Cessation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.