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NCT06415721 · ClinicalTrials.gov registry record · NA
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
A NA study of Alcohol Use Disorder and Alcoholism, sponsored by VA Palo Alto Health Care System.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06415721: Recruiting NA study of Alcohol Use Disorder and Alcoholism, sponsored by VA Palo Alto Health Care System.
NCT06415721 is a NA study of Alcohol Use Disorder and Alcoholism that is actively recruiting participants, run by VA Palo Alto Health Care System. The registered enrollment target is 40 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06415721, a NA study of Alcohol Use Disorder and Alcoholism, is actively recruiting participants, sponsored by VA Palo Alto Health Care System.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Alcohol Use Disorders are currently positioned as the third leading cause of preventable death in the United States, constituting a humanitarian crisis with substantial financial burden on society and medical facilities. While several pharmacological interventions exist, 60% of individuals who seek these treatments relapse to alcohol within 6 months. These high relapse rates are due in part to elevated brain response to alcohol cues in the environment. This study seeks to evaluate the efficacy of one session of functional Magnetic Resonance Imaging (fMRI) guided transcranial magnetic stimulation (TMS) as a strategy to reduce brain reactivity to alcohol cues.
Primary Outcome
The effect of real versus sham fMRI-guided TMS on alcohol cue reactivity will be assessed by comparing brain reactivity to images of alcohol ('alcohol cues') shown during the fMRI scan. Change in blood-oxygen level dependent signal magnitude will be measured within the striatum, a key brain region involved in cue-reactivity.
Conditions Studied
Interventions
- DEVICE Sham
- DEVICE Active Transcranial Magnetic Simulation
Study Locations (1)
California
- VA Palo Alto Health Care System - Palo Alto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-08-25 |
| Est. Completion | 2026-01-01 |
| Phase | NA |
What NCT06415721 shows while recruiting
NCT06415721 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (88% lower).
The record links to 5 conditions, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Sham is the first listed.
NCT06415721 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06415721 about?
NCT06415721 is a clinical study titled "Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder". Alcohol Use Disorders are currently positioned as the third leading cause of preventable death in the United States, constituting a humanitarian crisis with substantial financial burden on society and medical facilities. While several pharmacological interventions exist, 60% of individuals who seek ...
What is the current status of trial NCT06415721?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-08-25. Estimated completion is 2026-01-01.
What conditions does trial NCT06415721 study?
This clinical trial studies the following conditions: Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Drinking Behavior, Drinking Problem.
What interventions are being tested in trial NCT06415721?
The interventions under investigation include: Sham (DEVICE), Active Transcranial Magnetic Simulation (DEVICE).
Who is sponsoring clinical trial NCT06415721?
This trial is sponsored by VA Palo Alto Health Care System, which has 34 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06415721 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06415721's enrollment target sits among peer trials
40 138th of 184 higher than 40 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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