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NCT06559995 · ClinicalTrials.gov registry record · Phase 2

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

A Phase 2 study of Alcohol Use Disorder and Ketosis, sponsored by University of Pennsylvania.

Recruiting
Registry status
Phase 2
Development phase
30
Enrollment target
1
Study location

NCT06559995 is a Phase 2 study of Alcohol Use Disorder and Ketosis that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 30 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06559995, a Phase 2 study of Alcohol Use Disorder and Ketosis, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
Phase 2
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use disorder at the Hospital of the University of Pennsylvania, Cedar Detox Center.

Conditions Studied

Alcohol Use Disorder Ketosis Alcohol Withdrawal

Interventions

  • DIETARY_SUPPLEMENT ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,
  • DIAGNOSTIC_TEST magnetic resonance imaging session
  • DIETARY_SUPPLEMENT Placebo beverage

Study Locations (1)

Pennsylvania

  • Center for Studies of Addiction - Philadelphia

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2025-08-01
Est. Completion 2027-12
Phase Phase 2

Sponsor

University of Pennsylvania

1,423 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06559995

The ClinicalTrials.gov registry entry for NCT06559995 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (91% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Alcohol Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones, is the first listed.

NCT06559995 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT06559995 about?

NCT06559995 is a clinical study titled "Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder". The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use disorder at the Hospital of the University of Pennsylvania, Cedar Detox...

What is the current status of trial NCT06559995?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2025-08-01. Estimated completion is 2027-12.

What conditions does trial NCT06559995 study?

This clinical trial studies the following conditions: Alcohol Use Disorder, Ketosis, Alcohol Withdrawal.

What interventions are being tested in trial NCT06559995?

The interventions under investigation include: ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones, (DIETARY_SUPPLEMENT), magnetic resonance imaging session (DIAGNOSTIC_TEST), Placebo beverage (DIETARY_SUPPLEMENT).

Who is sponsoring clinical trial NCT06559995?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06559995 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.