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ClinicalTrials.gov 133 recruiting now official registry

Advanced Solid Tumor clinical trials

Every US clinical trial registered for Advanced Solid Tumor — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

190 US clinical trials · 133 currently recruiting

The research picture

Advanced Solid Tumor has 190 registered US clinical trials, 133 of them open to new participants right now — about 70% of the total.

133
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: Daiichi Sankyo

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 1,300 participants

Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

University of Chicago

NCT05166694

RECRUITING Phase 1 1,123 participants

First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors

DualityBio

NCT05438329

RECRUITING Phase 1 1,000 participants

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

DualityBio

NCT05785741

RECRUITING Phase 1 980 participants

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

BioNTech SE

NCT07070232

RECRUITING Phase 2 740 participants

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT06172478

RECRUITING Phase 1 540 participants

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT05875168

RECRUITING 500 participants

AIMS Cancer Outcomes Study

Advanced Integrative Medical Science Institute

NCT04495790

RECRUITING Phase 1 490 participants

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06238479

RECRUITING Phase 1 480 participants

A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas

CStone Pharmaceuticals

NCT05279300

RECRUITING Phase 1 464 participants

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

Debiopharm International

NCT04855656

RECRUITING Phase 1 430 participants

Study of AVZO-021 in Patients With Advanced Solid Tumors

Avenzo Therapeutics

NCT05867251

RECRUITING Phase 1 429 participants

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

Exelixis

NCT05932862

RECRUITING Phase 1 424 participants

A Study of YL242 in Subjects With Advanced Solid Tumors

MediLink Therapeutics (Suzhou) Co.

NCT07197827

RECRUITING Phase 1 420 participants

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of SLC-3010 Monotherapy and in Combination

Selecxine

NCT05525247

RECRUITING Phase 1 420 participants

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Eli Lilly and Company

NCT06465069

RECRUITING Phase 1 416 participants

Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors

Gilead Sciences

NCT05007782

RECRUITING Phase 1 364 participants

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

Synthekine

NCT05098132

RECRUITING Phase 1 358 participants

XTX301 in Patients With Advanced Solid Tumors

Xilio Development

NCT05684965

RECRUITING Phase 1 358 participants

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

GI Innovation

NCT05824975

RECRUITING Phase 1 351 participants

FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

Fate Therapeutics

NCT06241456

RECRUITING Phase 1 340 participants

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06561685

RECRUITING Phase 1 336 participants

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Bristol-Myers Squibb

NCT05245500

RECRUITING Phase 1 332 participants

A Study in Patients With Advanced Cancers

BiOneCure Therapeutics

NCT05320588

RECRUITING Phase 1 330 participants

A Study of PYX-201 in Advanced Solid Tumors

Pyxis Oncology

NCT05720117

RECRUITING Phase 1 317 participants

GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

GI Innovation

NCT04977453

RECRUITING Phase 1 312 participants

A Study of YL201 in Patients With Advanced Solid Tumors

MediLink Therapeutics (Suzhou) Co.

NCT05434234

RECRUITING Phase 1 308 participants

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

BeOne Medicines

NCT06233942

RECRUITING Phase 1 306 participants

Study in Advanced Solid Tumor Patients

Callio Therapeutics

NCT07300943

RECRUITING Phase 1 300 participants

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

BeiGene

NCT06120283

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 1 265 participants

A Study of EP0031 in Patients With Advanced RET-altered Malignancies

Ellipses Pharma

NCT05443126

RECRUITING Phase 1 260 participants

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

SillaJen

NCT05768932

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 1 254 participants

Evaluate the Safety and Clinical Activity of HH2853

Haihe Biopharma Co.

NCT04390737

RECRUITING Phase 1 250 participants

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

Daiichi Sankyo

NCT04145622

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 244 participants

An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors

BeOne Medicines

NCT06589596

RECRUITING Phase 1 240 participants

Phase 1/2 Study of TU2218 Alone and in Combination With Checkpoint Inhibitors in Patients With Advanced Solid Tumors

TiumBio Co.

NCT05204862

RECRUITING Phase 1 240 participants

A Study Evaluating ANV600 Single Agent or in Combination with Pembrolizumab in Participants with Advanced Solid Tumors (EXPAND-1)

Anaveon

NCT06470763

RECRUITING Phase 1 234 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors

Shanghai Allink Biotherapeutics Co.

NCT06707610

RECRUITING Phase 1 234 participants

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

Bristol-Myers Squibb

NCT06997029

RECRUITING Phase 1 220 participants

A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors

MediLink Therapeutics (Suzhou) Co.

NCT06859762

RECRUITING Phase 1 220 participants

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06545942

RECRUITING Phase 1 220 participants

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

Circle Pharma

NCT06577987

RECRUITING Phase 1 217 participants

A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors

BeOne Medicines

NCT05981703

RECRUITING Phase 1 210 participants

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

Adcendo ApS

NCT06597721

RECRUITING Phase 1 210 participants

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

Daiichi Sankyo

NCT06244485

RECRUITING Phase 1 204 participants

Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

OncoC4

NCT06635785

RECRUITING Phase 2 200 participants

A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)

Daiichi Sankyo

NCT06660654

RECRUITING Phase 1 200 participants

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

Volastra Therapeutics

NCT05902988

RECRUITING Phase 1 200 participants

SNV1521 in Participants with Advanced Solid Tumors

Synnovation Therapeutics

NCT06220864

RECRUITING Phase 1 192 participants

A Study of DS5361b in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT07182591

RECRUITING Phase 1 186 participants

SW-682 in Advanced Solid Tumors

SpringWorks Therapeutics

NCT06251310

RECRUITING Phase 1 178 participants

Study of GS-5319 in Adults With Solid Tumors

Gilead Sciences

NCT07128303

RECRUITING Phase 1 177 participants

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

Jazz Pharmaceuticals

NCT06108050

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 168 participants

A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

BeOne Medicines

NCT06625593

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 156 participants

A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

Eikon Therapeutics

NCT06253130

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 154 participants

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

Coherus Oncology

NCT06657144

RECRUITING Phase 1 151 participants

A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

1ST Biotherapeutics

NCT05761223

RECRUITING Phase 1 150 participants

PM14 Administered Intravenously to Patients with Advanced Solid Tumors

PharmaMar

NCT05076396

RECRUITING Phase 1 150 participants

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

NiKang Therapeutics

NCT06586957

RECRUITING Phase 1 150 participants

Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.

Oncomatryx Biopharma S.L.

NCT05547321

RECRUITING Phase 1 150 participants

A First-in-Human, Phase 1/2 Study of LAT010 in Patients With Advanced Solid Tumors (LIGHTSPEED-1)

Latticon Antibody Therapeutics

NCT06277219

RECRUITING Phase 1 147 participants

A Study Evaluating OBI-902 in Participants With Advanced Solid Tumors

OBI Pharma

NCT07124117

RECRUITING Phase 1 144 participants

EIS-12656 as Single Agent and in Combination in Patients With Specified Solid Tumors

Eisbach Bio

NCT06525298

RECRUITING Phase 2 141 participants

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

Day One Biopharmaceuticals

NCT04775485

RECRUITING Phase 1 140 participants

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

Nuvectis Pharma

NCT05873686

RECRUITING Phase 1 136 participants

Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors

Xilio Development

NCT04896697

RECRUITING Phase 1 132 participants

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06974110

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 1 125 participants

Clinical Trial of PM54 in Advanced Solid Tumors Patients.

PharmaMar

NCT05841563

RECRUITING Phase 1 120 participants

A Study of NB004 as Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors

Ningbo Newbay Technology Development Co.

NCT05036291

RECRUITING Phase 1 115 participants

A Beta-only IL-2 ImmunoTherapY Study

Medicenna Therapeutics

NCT05086692

RECRUITING Phase 1 112 participants

A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer

Edgewood Oncology

NCT04872166

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING Phase 1 110 participants

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

Lantern Pharma

NCT06132503

RECRUITING Phase 1 108 participants

Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

Strand Therapeutics

NCT06249048

RECRUITING Phase 1 105 participants

A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

BeOne Medicines

NCT07226349

RECRUITING Phase 1 102 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

Ipsen

NCT07213830

RECRUITING Phase 1 101 participants

A Study of KK2269 in Adult Participants With Solid Tumors

Kyowa Kirin Co.

NCT06266299

RECRUITING Phase 1 100 participants

This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

ABL Bio

NCT04762641

RECRUITING Phase 1 100 participants

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

InSilico Medicine Hong Kong Limited

NCT06566079

RECRUITING Phase 1 97 participants

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Ankyra Therapeutics

NCT06171750

RECRUITING Phase 1 91 participants

64Cu-GRIP B in Patients With Advanced Malignancies

Rahul Aggarwal

NCT05888532

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 1 90 participants

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Nectin Therapeutics

NCT05378425

RECRUITING Phase 1 90 participants

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

BeiGene

NCT06803680

RECRUITING Phase 1 90 participants

Study of APR-1051 in Patients With Advanced Solid Tumors

Aprea Therapeutics

NCT06260514

RECRUITING Phase 1 90 participants

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05103683

RECRUITING Phase 1 87 participants

Study of BG-T187 Alone and in Combination With Other Therapeutic Agents in Participants With Advanced Solid Tumors

BeiGene

NCT06598800

RECRUITING Phase 1 87 participants

Study of CHS-114 in Participants With Advanced Solid Tumors

Coherus Oncology

NCT05635643

RECRUITING Phase 1 86 participants

CLN-617 Alone and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Cullinan Therapeutics

NCT06035744

RECRUITING Phase 1 86 participants

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

BeOne Medicines

NCT07222267

RECRUITING Phase 1 85 participants

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06833008

Phase Distribution

PhaseTrial count
Phase 1 180
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumor Trial Landscape

ClinicalTrials.gov lists 190 US studies indexed under Advanced Solid Tumor, and 133 of those are currently open to recruitment — roughly 70% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Advanced Solid Tumor shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 186 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Advanced Solid Tumor is led by Daiichi Sankyo with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumor?

PlainTrial tracks 190 US clinical trials for Advanced Solid Tumor, of which 133 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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