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NCT06793488 · ClinicalTrials.gov registry record · Early Phase 1
Anxiety During Abstinence in AUD
A Early Phase 1 study of Alcohol Use Disorder, sponsored by Columbia University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06793488: Recruiting Early Phase 1 study of Alcohol Use Disorder, sponsored by Columbia University.
NCT06793488 is a Early Phase 1 study of Alcohol Use Disorder that is actively recruiting participants, run by Columbia University. The registered enrollment target is 60 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06793488, a Early Phase 1 study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry in early abstinence in AUD 2. To examine how anxiety and anxiety related-neurobiological circuitry change over the course of abstinence in AUD Researchers will recruit both participants with AUD and healthy volunteers. The participants with AUD will be prescribed disulfiram, a medication that helps participants with AUD stay abstinent. Healthy volunteers will not receive antabuse. Patients with AUD will undergo fMRI scanning both after 1 week and 3 months of disulfiram treatment. Healthy volunteers will undergo fMRI once.
Primary Outcome
Resting state functional connectivity between the bed nucleus of the stria terminalis and anterior insula resting state functional connectivity. Correlation values range from -1 to +1, with higher values indicating stronger connectivity.
Conditions Studied
Interventions
- DRUG Disulfiram 250 mg
- DIAGNOSTIC_TEST functional MRI
Study Locations (1)
New York
- Columbia University Irving Medical Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-09-15 |
| Est. Completion | 2029-08-30 |
| Phase | Early Phase 1 |
What NCT06793488 shows while recruiting
NCT06793488 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (82% lower).
The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Disulfiram 250 mg is the first listed.
NCT06793488 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06793488 about?
NCT06793488 is a clinical study titled "Anxiety During Abstinence in AUD". The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry...
What is the current status of trial NCT06793488?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2025-09-15. Estimated completion is 2029-08-30.
What conditions does trial NCT06793488 study?
This clinical trial studies the following conditions: Alcohol Use Disorder.
What interventions are being tested in trial NCT06793488?
The interventions under investigation include: Disulfiram 250 mg (DRUG), functional MRI (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06793488?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06793488 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06793488's enrollment target sits among peer trials
60 113th of 184 higher than 65 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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