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NCT06793488 · ClinicalTrials.gov registry record · Early Phase 1

Anxiety During Abstinence in AUD

A Early Phase 1 study of Alcohol Use Disorder, sponsored by Columbia University.

Recruiting
Registry status
Early Phase 1
Development phase
60
Enrollment target
1
Study location

NCT06793488 is a Early Phase 1 study of Alcohol Use Disorder that is actively recruiting participants, run by Columbia University. The registered enrollment target is 60 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06793488, a Early Phase 1 study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Columbia University.

RECRUITING
Registry status
Early Phase 1
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry in early abstinence in AUD 2. To examine how anxiety and anxiety related-neurobiological circuitry change over the course of abstinence in AUD Researchers will recruit both participants with AUD and healthy volunteers. The participants with AUD will be prescribed disulfiram, a medication that helps participants with AUD stay abstinent. Healthy volunteers will not receive antabuse. Patients with AUD will undergo fMRI scanning both after 1 week and 3 months of disulfiram treatment. Healthy volunteers will undergo fMRI once.

Conditions Studied

Alcohol Use Disorder

Interventions

  • DRUG Disulfiram 250 mg
  • DIAGNOSTIC_TEST functional MRI

Study Locations (1)

New York

  • Columbia University Irving Medical Center - New York

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-09-15
Est. Completion 2029-08-30
Phase Early Phase 1

Sponsor

Columbia University

958 total trials

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What the Registry Record Tells You About NCT06793488

The ClinicalTrials.gov registry entry for NCT06793488 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (82% lower). The listed sponsor is Columbia University, which has 958 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Disulfiram 250 mg is the first listed.

NCT06793488 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.

Frequently Asked Questions

What is clinical trial NCT06793488 about?

NCT06793488 is a clinical study titled "Anxiety During Abstinence in AUD". The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry...

What is the current status of trial NCT06793488?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2025-09-15. Estimated completion is 2029-08-30.

What conditions does trial NCT06793488 study?

This clinical trial studies the following conditions: Alcohol Use Disorder.

What interventions are being tested in trial NCT06793488?

The interventions under investigation include: Disulfiram 250 mg (DRUG), functional MRI (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT06793488?

This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06793488 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.