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ClinicalTrials.gov 108 recruiting now official registry

Endometrial Cancer clinical trials

108 of 188 indexed Endometrial Cancer trials are currently recruiting.

188 US clinical trials · 108 currently recruiting

Endometrial Cancer is the subject of 188 registered US clinical trials on ClinicalTrials.gov, 108 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 118 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.

The research picture

Endometrial Cancer has 188 registered US clinical trials, 108 of them open to new participants right now, about 57% of the total.

108
recruiting participants now
57%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 174Phase 244Phase 314Phase 41

Active & Recent Trials

188 total, page 1 of 4

RECRUITING 25,000 participants

Avera Cancer Sequencing and Analytics Protocol (ASAP)

Avera McKennan Hospital & University Health Center

NCT05142033

RECRUITING 7,000 participants

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Adela

NCT05366881

RECRUITING 6,000 participants

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

Northwestern University

NCT00005095

RECRUITING 3,110 participants

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

Mayo Clinic

NCT05051722

RECRUITING 2,000 participants

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies

Elephas

NCT07327489

RECRUITING 1,715 participants

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Memorial Sloan Kettering Cancer Center

NCT04291612

RECRUITING 1,500 participants

The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer in Tampons

University of Alabama at Birmingham

NCT03538665

RECRUITING Phase 3 1,123 participants

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Merck Sharp & Dohme

NCT06952504

RECRUITING 1,120 participants

Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

Weill Medical College of Cornell University

NCT06096688

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francisco

NCT05056077

RECRUITING Phase 1 890 participants

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

Regeneron Pharmaceuticals

NCT03564340

RECRUITING Phase 1 764 participants

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Genmab

NCT05579366

RECRUITING Phase 2 740 participants

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT06172478

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 3 710 participants

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

Daiichi Sankyo

NCT07022483

RECRUITING Phase 3 700 participants

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

AstraZeneca

NCT07044336

RECRUITING NA 625 participants

MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer

Rachel Miller

NCT06677112

RECRUITING NA 625 participants

Comprehensive Outcomes for After Cancer Health

Pack Health

NCT05349227

RECRUITING Phase 1 612 participants

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

Regeneron Pharmaceuticals

NCT04590326

RECRUITING Phase 3 600 participants

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

AstraZeneca

NCT06989112

RECRUITING Phase 3 544 participants

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

Genmab

NCT07166094

RECRUITING Phase 1 506 participants

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

AstraZeneca

NCT05797168

RECRUITING Phase 3 480 participants

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

BioNTech SE

NCT06340568

RECRUITING Phase 1 470 participants

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

SystImmune

NCT05983432

RECRUITING Phase 1 460 participants

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

AstraZeneca

NCT05123482

RECRUITING Phase 2 454 participants

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

AstraZeneca

NCT05489211

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING Phase 1 430 participants

Study of AVZO-021 in Patients With Advanced Solid Tumors

Avenzo Therapeutics

NCT05867251

RECRUITING Phase 2 393 participants

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

Canadian Cancer Trials Group

NCT05640999

RECRUITING NA 350 participants

Use of an Intrauterine Manipulator and Its Correlation with Positive Peritoneal Cytology in Early Stage Endometrial Cancers

WellSpan Health

NCT04570553

RECRUITING Phase 1 319 participants

A Study of XMT-1660 in Participants With Solid Tumors

Mersana Therapeutics

NCT05377996

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING Phase 1 282 participants

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Xencor

NCT06276491

RECRUITING Phase 1 280 participants

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

SystImmune

NCT06293898

RECRUITING NA 278 participants

Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

Anthony Costales, MD

NCT04586959

RECRUITING Phase 3 276 participants

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Karyopharm Therapeutics

NCT05611931

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 2 270 participants

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

Corcept Therapeutics

NCT06906341

RECRUITING 270 participants

Development of a Shared Decision Tool to Facilitate Uptake of the Levonorgestrel-releasing Intrauterine System for the Primary Prevention of Endometrial Cancer

M.D. Anderson Cancer Center

NCT07382583

RECRUITING Phase 2 268 participants

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

Kartos Therapeutics

NCT05797831

RECRUITING Phase 1 265 participants

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

Whitehawk Therapeutics

NCT07470853

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 3 258 participants

Vaginal Cuff Brachytherapy Fractionation Study

Kara Romano, MD

NCT03785288

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 241 participants

A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With HR+ Breast Cancer and Other Select Solid Tumors

Totus Medicines

NCT05683418

RECRUITING Phase 1 226 participants

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

Whitehawk Therapeutics

NCT07444814

RECRUITING Phase 1 216 participants

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

IDEAYA Biosciences

NCT05787587

RECRUITING Phase 1 205 participants

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

NiKang Therapeutics

NCT07029399

RECRUITING Phase 1 205 participants

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

Terremoto Biosciences

NCT07109726

RECRUITING Phase 1 200 participants

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

Sutro Biopharma

NCT07227168

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Phase Distribution

PhaseTrial count
Phase 1 74
Phase 2 44
Phase 3 14
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Endometrial Cancer Trial Landscape

188 indexed Endometrial Cancer studies · 108 recruiting (57%).

Phase mix: 15 late (III/IV) vs 118 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Endometrial Cancer?

PlainTrial tracks 188 US clinical trials for Endometrial Cancer, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Endometrial Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.