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ClinicalTrials.gov 107 recruiting now official registry

Endometrial Cancer clinical trials

Every US clinical trial registered for Endometrial Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

187 US clinical trials · 107 currently recruiting

The research picture

Endometrial Cancer has 187 registered US clinical trials, 107 of them open to new participants right now — about 57% of the total.

107
recruiting participants now
57%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 25,000 participants

Avera Cancer Sequencing and Analytics Protocol (ASAP)

Avera McKennan Hospital & University Health Center

NCT05142033

RECRUITING 7,000 participants

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Adela

NCT05366881

RECRUITING 6,000 participants

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

Northwestern University

NCT00005095

RECRUITING 3,110 participants

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

Mayo Clinic

NCT05051722

RECRUITING 2,000 participants

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies

Elephas

NCT07327489

RECRUITING 1,715 participants

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Memorial Sloan Kettering Cancer Center

NCT04291612

RECRUITING 1,500 participants

The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer in Tampons

University of Alabama at Birmingham

NCT03538665

RECRUITING Phase 3 1,123 participants

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Merck Sharp & Dohme

NCT06952504

RECRUITING 1,120 participants

Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

Weill Medical College of Cornell University

NCT06096688

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francis

NCT05056077

RECRUITING Phase 1 890 participants

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

Regeneron Pharmaceuticals

NCT03564340

RECRUITING Phase 1 764 participants

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Genmab

NCT05579366

RECRUITING Phase 2 740 participants

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT06172478

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 3 710 participants

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

Daiichi Sankyo

NCT07022483

RECRUITING Phase 3 700 participants

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

AstraZeneca

NCT07044336

RECRUITING NA 625 participants

MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer

Rachel Miller

NCT06677112

RECRUITING NA 625 participants

Comprehensive Outcomes for After Cancer Health

Pack Health

NCT05349227

RECRUITING Phase 1 612 participants

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

Regeneron Pharmaceuticals

NCT04590326

RECRUITING Phase 3 600 participants

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

AstraZeneca

NCT06989112

RECRUITING Phase 3 544 participants

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

Genmab

NCT07166094

RECRUITING Phase 1 506 participants

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

AstraZeneca

NCT05797168

RECRUITING Phase 3 480 participants

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

BioNTech SE

NCT06340568

RECRUITING Phase 1 470 participants

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

SystImmune

NCT05983432

RECRUITING Phase 1 460 participants

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

AstraZeneca

NCT05123482

RECRUITING Phase 2 454 participants

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

AstraZeneca

NCT05489211

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING Phase 1 430 participants

Study of AVZO-021 in Patients With Advanced Solid Tumors

Avenzo Therapeutics

NCT05867251

RECRUITING Phase 2 393 participants

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

Canadian Cancer Trials Group

NCT05640999

RECRUITING NA 350 participants

Use of an Intrauterine Manipulator and Its Correlation with Positive Peritoneal Cytology in Early Stage Endometrial Cancers

WellSpan Health

NCT04570553

RECRUITING Phase 1 319 participants

A Study of XMT-1660 in Participants With Solid Tumors

Mersana Therapeutics

NCT05377996

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING Phase 1 282 participants

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Xencor

NCT06276491

RECRUITING Phase 1 280 participants

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

SystImmune

NCT06293898

RECRUITING Phase 3 276 participants

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Karyopharm Therapeutics

NCT05611931

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 2 270 participants

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

Corcept Therapeutics

NCT06906341

RECRUITING 270 participants

Development of a Shared Decision Tool to Facilitate Uptake of the Levonorgestrel-releasing Intrauterine System for the Primary Prevention of Endometrial Cancer

M.D. Anderson Cancer Center

NCT07382583

RECRUITING Phase 2 268 participants

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

Kartos Therapeutics

NCT05797831

RECRUITING Phase 1 265 participants

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

Whitehawk Therapeutics

NCT07470853

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 3 258 participants

Vaginal Cuff Brachytherapy Fractionation Study

Kara Romano, MD

NCT03785288

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 241 participants

A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With HR+ Breast Cancer and Other Select Solid Tumors

Totus Medicines

NCT05683418

RECRUITING Phase 1 226 participants

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

Whitehawk Therapeutics

NCT07444814

RECRUITING Phase 1 216 participants

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

IDEAYA Biosciences

NCT05787587

RECRUITING Phase 1 205 participants

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

NiKang Therapeutics

NCT07029399

RECRUITING Phase 1 205 participants

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

Terremoto Biosciences

NCT07109726

RECRUITING Phase 1 200 participants

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

Sutro Biopharma

NCT07227168

RECRUITING Phase 2 200 participants

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Jazz Pharmaceuticals

NCT06695845

RECRUITING NA 192 participants

Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)

Northwestern University

NCT05743517

RECRUITING Phase 2 180 participants

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Dana-Farber Cancer Institute

NCT03675893

RECRUITING Phase 1 160 participants

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Eikon Therapeutics

NCT07262619

RECRUITING Phase 1 150 participants

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

Normunity AccelCo

NCT07182149

RECRUITING Phase 1 148 participants

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Alliance Foundation Trials

NCT04486352

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING Phase 1 132 participants

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06974110

RECRUITING Phase 1 130 participants

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Sairopa B.V.

NCT05856981

RECRUITING NA 120 participants

Mindfulness in Endometrial and Cervical Cancer

St. Louis University

NCT04512144

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING Phase 1 100 participants

Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer

University of Chicago

NCT04683653

RECRUITING 100 participants

DESTINY-PANTUMOUR04

AstraZeneca

NCT07124000

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING Phase 1 90 participants

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

Portage Biotech

NCT04969315

RECRUITING Phase 1 90 participants

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05103683

RECRUITING Phase 1 80 participants

A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

Context Therapeutics

NCT06515613

RECRUITING Phase 2 75 participants

A Study of Elacestrant Alone or in Combination With Abemaciclib in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT07209449

RECRUITING NA 70 participants

ASk Questions in GYnecologic Oncology (ASQ-GYO)

Ira Winer

NCT06339827

RECRUITING NA 70 participants

Hugo™ Robotic-Assisted Surgery (RAS) System in Gynecological Subjects (Embrace Gynecology)

Medtronic - MITG

NCT07120945

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 2 68 participants

Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies

University of Utah

NCT05979610

RECRUITING Phase 2 62 participants

Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery

Memorial Sloan Kettering Cancer Center

NCT04774419

RECRUITING Phase 1 61 participants

177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

Radiopharm Theranostics

NCT07189871

RECRUITING Phase 2 60 participants

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

Iovance Biotherapeutics

NCT06481592

RECRUITING Phase 1 60 participants

Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer

National Cancer Institute (NCI)

NCT06253494

RECRUITING NA 60 participants

Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers

Jonsson Comprehensive Cancer Center

NCT06538337

RECRUITING Phase 1 58 participants

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

UNC Lineberger Comprehensive Cancer Center

NCT05542407

RECRUITING Phase 2 50 participants

Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer

Alessandro Santin

NCT03832361

RECRUITING Phase 2 50 participants

A Study of Ivonescimab in People With Endometrial and Cervical Cancers

Memorial Sloan Kettering Cancer Center

NCT06925724

RECRUITING Phase 1 50 participants

BP1001-A in Patients With Advanced or Recurrent Solid Tumors

Bio-Path Holdings

NCT04196257

RECRUITING NA 50 participants

Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial

Medical College of Wisconsin

NCT07227077

RECRUITING 45 participants

Endometrial Cancer, Risk Factors and Prevention Strategies: Perspectives of Patients and At-Risk Women

M.D. Anderson Cancer Center

NCT06409052

RECRUITING 40 participants

Vaginal Fluid Collection for Detection of Endometrial Cancer

Innovis

NCT06294886

RECRUITING Phase 2 40 participants

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

Faeth Therapeutics

NCT06463028

RECRUITING Phase 1 37 participants

Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma

University of Alabama at Birmingham

NCT05559879

RECRUITING Phase 1 36 participants

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Washington University School of Medicine

NCT06795009

RECRUITING Early Phase 1 36 participants

A Study of a Weight Loss Intervention in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT06751589

RECRUITING 35 participants

The Better, Harder, Faster, Stronger Study

Wake Forest University Health Sciences

NCT07220512

RECRUITING Phase 2 32 participants

ALPINE: Maintenance Letrozole/Abemaciclib

Dana-Farber Cancer Institute

NCT06366347

RECRUITING Phase 2 32 participants

Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin

Dana-Farber Cancer Institute

NCT06677190

RECRUITING NA 30 participants

ctDNA Testing to Inform Standard-of-Care Treatment Decisions in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT07270666

RECRUITING NA 30 participants

Multimedia Aid for Genetic Testing in Gynecologic Oncology

UNC Lineberger Comprehensive Cancer Center

NCT07084168

RECRUITING NA 30 participants

Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy

Northwestern University

NCT05990426

RECRUITING NA 30 participants

Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

Dana-Farber Cancer Institute

NCT04997096

RECRUITING Phase 2 29 participants

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Aadi Bioscience

NCT05997017

RECRUITING Early Phase 1 28 participants

A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT05691010

RECRUITING Phase 1 27 participants

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Tanabe Pharma America

NCT06943521

Phase Distribution

PhaseTrial count
Phase 1 74
Phase 2 44
Phase 3 14
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Endometrial Cancer Trial Landscape

ClinicalTrials.gov lists 187 US studies indexed under Endometrial Cancer, and 107 of those are currently open to recruitment — roughly 57% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Endometrial Cancer shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 118 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Endometrial Cancer is led by Memorial Sloan Kettering Cancer Center with 17 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Endometrial Cancer?

PlainTrial tracks 187 US clinical trials for Endometrial Cancer, of which 107 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Endometrial Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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