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NCT05957159 · ClinicalTrials.gov registry record · Early Phase 1

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

A Early Phase 1 study of Alcohol Use Disorder, sponsored by Yale University.

Recruiting
Registry status
Early Phase 1
Development phase
100
Enrollment target
1
Study location

NCT05957159 is a Early Phase 1 study of Alcohol Use Disorder that is actively recruiting participants, run by Yale University. The registered enrollment target is 100 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (70% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05957159, a Early Phase 1 study of Alcohol Use Disorder, is actively recruiting participants, sponsored by Yale University.

RECRUITING
Registry status
Early Phase 1
Development phase
100 participants
Enrollment target
1
Study location

Study Summary

The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR and KOR, separately and jointly, to key clinical outcomes (e.g., craving, mood, withdrawal, time to lapse) during a quit attempt.

Conditions Studied

Alcohol Use Disorder

Interventions

  • OTHER Detoxification Program
  • RADIATION PKAB
  • RADIATION CFN

Study Locations (1)

Connecticut

  • Yale University - New Haven

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2023-11-07
Est. Completion 2028-11-01
Phase Early Phase 1

Sponsor

Yale University

1,492 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05957159

The ClinicalTrials.gov registry entry for NCT05957159 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (70% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Detoxification Program is the first listed.

NCT05957159 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.

Frequently Asked Questions

What is clinical trial NCT05957159 about?

NCT05957159 is a clinical study titled "Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder". The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR and KOR, separately a...

What is the current status of trial NCT05957159?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 100 participants. The study started on 2023-11-07. Estimated completion is 2028-11-01.

What conditions does trial NCT05957159 study?

This clinical trial studies the following conditions: Alcohol Use Disorder.

What interventions are being tested in trial NCT05957159?

The interventions under investigation include: Detoxification Program (OTHER), PKAB (RADIATION), CFN (RADIATION).

Who is sponsoring clinical trial NCT05957159?

This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05957159 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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