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ClinicalTrials.gov 109 recruiting now official registry

Alcohol Use Disorder clinical trials

109 of 185 indexed Alcohol Use Disorder trials are currently recruiting.

185 US clinical trials · 109 currently recruiting

Alcohol Use Disorder is the subject of 185 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 75 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 13 of these trials.

The research picture

Alcohol Use Disorder has 185 registered US clinical trials, 109 of them open to new participants right now, about 59% of the total.

109
recruiting participants now
59%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
13
top sponsor: Yale University
Phase 126Phase 249Phase 35Phase 43

Active & Recent Trials

185 total, page 1 of 4

RECRUITING 10,000 participants

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

National Institute on Drug Abuse (NIDA)

NCT06552741

RECRUITING 7,500 participants

NIAAA Natural History Protocol

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02231840

RECRUITING NA 1,500 participants

Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment

Kaiser Permanente

NCT06318026

RECRUITING Phase 3 1,100 participants

A Study of Brenipatide in Participants With Alcohol Use Disorder

Eli Lilly and Company

NCT07219953

RECRUITING Phase 3 1,100 participants

A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

Eli Lilly and Company

NCT07219966

RECRUITING NA 800 participants

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

University of Michigan

NCT05665179

RECRUITING NA 750 participants

A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients

Clemson University

NCT06479681

RECRUITING NA 744 participants

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

Stanford University

NCT05619185

RECRUITING NA 600 participants

Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs

University of Texas, El Paso

NCT05800899

RECRUITING NA 500 participants

Enhancing Prospective Thinking in Early Recovery (HOME)

Indiana University

NCT06302413

RECRUITING 475 participants

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT05677321

RECRUITING NA 450 participants

Promoting Alcohol Treatment Engagement Post-hospitalization

Yale University

NCT05338151

RECRUITING NA 405 participants

TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk

University of Kentucky

NCT05576350

RECRUITING NA 400 participants

Leveraging Virtual Care Strategies to Improve Access and Treatment for Individuals With Alcohol Use Disorders

University of Michigan

NCT05594238

RECRUITING NA 400 participants

Brief Family Involved Treatment Telehealth

Medical University of South Carolina

NCT05674409

RECRUITING 400 participants

Emergency Medicine Peer Outreach Worker Engagement for Recovery

University of California, Los Angeles

NCT06320015

RECRUITING NA 400 participants

Behavioral and Functional Task Development, Implementation, and Testing

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02108054

RECRUITING Phase 2 350 participants

Cannabis' Impact on Alcohol Consumption

Brown University

NCT05389930

RECRUITING Phase 2 300 participants

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

Evon Medics

NCT06434818

RECRUITING NA 300 participants

Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes

Michigan State University

NCT05564663

RECRUITING Phase 2 300 participants

A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder

Eli Lilly and Company

NCT06817356

RECRUITING NA 298 participants

Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease

University of Wisconsin, Madison

NCT06305624

RECRUITING NA 294 participants

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

Massachusetts General Hospital

NCT06395467

RECRUITING NA 256 participants

Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

University of Minnesota

NCT05117255

RECRUITING Phase 2 250 participants

Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

Ohio State University

NCT07214207

RECRUITING Early Phase 1 250 participants

Impulsivity Domains and Subjective Response

Jessica Weafer

NCT05929677

RECRUITING Phase 2 250 participants

Brexpiprazole in Alcohol Use Disorder

University of Colorado, Denver

NCT04066192

RECRUITING Phase 3 240 participants

Emergency Department-Initiated Medications for Alcohol Use Disorder

Yale University

NCT05827159

RECRUITING 240 participants

Alcohol and the Social Brain: an Alcohol-Administration Hyperscanning Study

University of Illinois at Urbana-Champaign

NCT06687525

RECRUITING NA 214 participants

Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment

Butler Hospital

NCT04667520

RECRUITING Phase 2 210 participants

Motivation for IV Alcohol Self-Administration in Humans

University of California, Los Angeles

NCT06494891

RECRUITING NA 200 participants

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Johns Hopkins University

NCT03845205

RECRUITING Phase 2 200 participants

Guanfacine for Alcohol Use Disorder (AUD)

Indiana University

NCT06629259

RECRUITING Phase 2 200 participants

Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

NYU Langone Health

NCT06349083

RECRUITING NA 200 participants

Virtual Incentive Treatment for Alcohol

Washington State University

NCT06265506

RECRUITING Phase 2 200 participants

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Texas A&M University

NCT05959434

RECRUITING NA 186 participants

Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)

Brainsway

NCT07216872

RECRUITING Phase 2 180 participants

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

Medical University of South Carolina

NCT04523922

RECRUITING Phase 2 180 participants

Alcohol Use Disorder and Cannabidiol

University of Colorado, Denver

NCT05613608

RECRUITING NA 176 participants

AAT for Alcohol Use Disorder in Veterans

VA Office of Research and Development

NCT05372029

RECRUITING 170 participants

Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

University Hospitals Cleveland Medical Center

NCT06864819

RECRUITING NA 162 participants

A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings

University of Massachusetts, Worcester

NCT06118346

RECRUITING Phase 3 160 participants

Electronic Harm Reduction Treatment for Alcohol

University of Washington

NCT06702007

RECRUITING Phase 1 160 participants

Sex Differences in the Response to Abstinence From Alcohol.

Indiana University

NCT03827460

RECRUITING Phase 2 160 participants

Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

VA Connecticut Healthcare System

NCT05042102

RECRUITING NA 150 participants

Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)

The University of Texas Health Science Center at San Antonio

NCT06648642

RECRUITING Phase 2 150 participants

Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

NYU Langone Health

NCT03667846

RECRUITING NA 150 participants

Alcohol Research in HIV: Relapse Prevention

Johns Hopkins University

NCT05163301

RECRUITING Phase 2 150 participants

Pregnenolone for the Treatment of Alcohol Use Disorder

Yale University

NCT05781009

RECRUITING 150 participants

Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

Yale University

NCT06371404

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 49
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcohol Use Disorder Trial Landscape

185 indexed Alcohol Use Disorder studies · 109 recruiting (59%).

Phase mix: 8 late (III/IV) vs 75 early (I/II).

Top sponsor: Yale University (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcohol Use Disorder?

PlainTrial tracks 185 US clinical trials for Alcohol Use Disorder, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcohol Use Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.