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NCT05518500 · ClinicalTrials.gov registry record · Phase 4
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
A Phase 4 study of Aging and Vaccine Response, sponsored by The Jackson Laboratory.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT05518500: Recruiting Phase 4 study of Aging and Vaccine Response, sponsored by The Jackson Laboratory.
NCT05518500 is a Phase 4 study of Aging and Vaccine Response that is actively recruiting participants, run by The Jackson Laboratory. The registered enrollment target is 75 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05518500, a Phase 4 study of Aging and Vaccine Response, is actively recruiting participants, sponsored by The Jackson Laboratory.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults. The investigators will recruit and longitudinally follow a cohort of 75 older adults (65 years and older) who will receive three different influenza vaccines over three annual influenza seasons. Blood samples will be collected from the participants at sixteen study visits over three years. Nasal swab and stool samples will also be collected from participants at seven time-points across the study period. The study is not designed to assess safety or tolerability of the influenza vaccines administered as part of this study.
Primary Outcome
In year one, healthy older participants will receive Fluzone Quadrivalent HD vaccine. Longitudinal blood samples will be collected and influenza-specific antibody responses will be assessed. Change in antibody response will be measured using Hemagglutination Inhibition (HAI) from baseline to day 35 and day 180.
Conditions Studied
Interventions
- BIOLOGICAL Flu Vaccine (Year 1)
- BIOLOGICAL Flu Vaccine (Year 2)
- BIOLOGICAL Flu Vaccine (Year 3)
Study Locations (1)
Connecticut
- UConn Health, Center On Aging - Farmington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2022-08-31 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 4 |
What NCT05518500 shows while recruiting
NCT05518500 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Aging appearing as the primary indexed condition, and to 3 interventions - of which Flu Vaccine (Year 1) is the first listed.
NCT05518500 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT05518500 about?
NCT05518500 is a clinical study titled "A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults". This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults. The investigators will recruit and longitudinally follow a cohort of 75 older adults (65 years and older) who will receive three different influenza vac...
What is the current status of trial NCT05518500?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 75 participants. The study started on 2022-08-31. Estimated completion is 2026-12-31.
What conditions does trial NCT05518500 study?
This clinical trial studies the following conditions: Aging, Vaccine Response, Influenza Vaccine, Dendritic Cell.
What interventions are being tested in trial NCT05518500?
The interventions under investigation include: Flu Vaccine (Year 1) (BIOLOGICAL), Flu Vaccine (Year 2) (BIOLOGICAL), Flu Vaccine (Year 3) (BIOLOGICAL).
Who is sponsoring clinical trial NCT05518500?
This trial is sponsored by The Jackson Laboratory, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05518500 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05518500's enrollment target sits among peer trials
75 115th of 262 higher than 146 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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