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NCT05518500 · ClinicalTrials.gov registry record · Phase 4

A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

A Phase 4 study of Aging and Vaccine Response, sponsored by The Jackson Laboratory.

Recruiting
Registry status
Phase 4
Development phase
75
Enrollment target
1
Study location

NCT05518500 is a Phase 4 study of Aging and Vaccine Response that is actively recruiting participants, run by The Jackson Laboratory. The registered enrollment target is 75 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05518500, a Phase 4 study of Aging and Vaccine Response, is actively recruiting participants, sponsored by The Jackson Laboratory.

RECRUITING
Registry status
Phase 4
Development phase
75 participants
Enrollment target
1
Study location

Study Summary

This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults. The investigators will recruit and longitudinally follow a cohort of 75 older adults (65 years and older) who will receive three different influenza vaccines over three annual influenza seasons. Blood samples will be collected from the participants at sixteen study visits over three years. Nasal swab and stool samples will also be collected from participants at seven time-points across the study period. The study is not designed to assess safety or tolerability of the influenza vaccines administered as part of this study.

Conditions Studied

Aging Vaccine Response Influenza Vaccine Dendritic Cell

Interventions

  • BIOLOGICAL Flu Vaccine (Year 1)
  • BIOLOGICAL Flu Vaccine (Year 2)
  • BIOLOGICAL Flu Vaccine (Year 3)

Study Locations (1)

Connecticut

  • UConn Health, Center On Aging - Farmington

Trial Details

FieldValue
Enrollment Target 75 participants
Start Date 2022-08-31
Est. Completion 2026-12-31
Phase Phase 4

Sponsor

The Jackson Laboratory

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05518500

The ClinicalTrials.gov registry entry for NCT05518500 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 75 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The listed sponsor is The Jackson Laboratory, which has 2 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Aging appearing as the primary indexed condition, and to 3 interventions - of which Flu Vaccine (Year 1) is the first listed.

NCT05518500 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.

Frequently Asked Questions

What is clinical trial NCT05518500 about?

NCT05518500 is a clinical study titled "A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults". This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults. The investigators will recruit and longitudinally follow a cohort of 75 older adults (65 years and older) who will receive three different influenza vac...

What is the current status of trial NCT05518500?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 75 participants. The study started on 2022-08-31. Estimated completion is 2026-12-31.

What conditions does trial NCT05518500 study?

This clinical trial studies the following conditions: Aging, Vaccine Response, Influenza Vaccine, Dendritic Cell.

What interventions are being tested in trial NCT05518500?

The interventions under investigation include: Flu Vaccine (Year 1) (BIOLOGICAL), Flu Vaccine (Year 2) (BIOLOGICAL), Flu Vaccine (Year 3) (BIOLOGICAL).

Who is sponsoring clinical trial NCT05518500?

This trial is sponsored by The Jackson Laboratory, which has 2 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05518500 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.