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NCT05018117 · ClinicalTrials.gov registry record · Early Phase 1
Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
A Early Phase 1 study of Aging, sponsored by University of California, Berkeley.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05018117: Recruiting Early Phase 1 study of Aging, sponsored by University of California, Berkeley.
NCT05018117 is a Early Phase 1 study of Aging that is actively recruiting participants, run by University of California, Berkeley. The registered enrollment target is 48 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05018117, a Early Phase 1 study of Aging, is actively recruiting participants, sponsored by University of California, Berkeley.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment). In part, nicotine does this by activating inhibitory neurons in the auditory cortex. Since age-related hearing deficits result, in part, from the loss of inhibitory neurons in auditory cortex, this project will determine whether nicotine's effects can compensate for reduced inhibition in the aging auditory cortex and thereby restore auditory function. The investigators will use functional magnetic resonance imaging (fMRI) to measure the selectivity of responses in auditory cortex to tones of various frequencies. The investigators will measure the effects of nicotine (administered as chewing gum) and aging on these fMRI response properties. The investigators hypothesize that frequency selectivity will decrease with aging and increase following nicotine administration.
Primary Outcome
Functional magnetic resonance imaging (fMRI) responses to pure tone stimuli ranging from 88-8000 Hz will be recorded. For each voxel in objectively identified auditory cortical area, a tuning curve model will be fit to the data. One of the parameters of this model is the width of frequency tuning of excitatory responses, and this is the primary outcome measure.
Conditions Studied
Interventions
- OTHER Placebo gum
- DRUG Nicotine gum
Study Locations (1)
California
- University of California, Berkeley - Berkeley
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2022-06-06 |
| Est. Completion | 2025-12-31 |
| Phase | Early Phase 1 |
What NCT05018117 shows while recruiting
NCT05018117 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Placebo gum is the first listed.
NCT05018117 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05018117 about?
NCT05018117 is a clinical study titled "Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex". Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment). In part, nicotine does this by activating inhibitory neurons in the auditory cortex. Since age-r...
What is the current status of trial NCT05018117?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 48 participants. The study started on 2022-06-06. Estimated completion is 2025-12-31.
What conditions does trial NCT05018117 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT05018117?
The interventions under investigation include: Placebo gum (OTHER), Nicotine gum (DRUG).
Who is sponsoring clinical trial NCT05018117?
This trial is sponsored by University of California, Berkeley, which has 72 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05018117 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05018117's enrollment target sits among peer trials
48 159th of 262 higher than 103 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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