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NCT03896529 · ClinicalTrials.gov registry record · NA
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
A NA study of Anxiety and Aging, sponsored by Georgia Institute of Technology.
- Recruiting
- Registry status
- NA
- Development phase
- 85
- Enrollment target
- 1
- Study location
NCT03896529: Recruiting NA study of Anxiety and Aging, sponsored by Georgia Institute of Technology.
NCT03896529 is a NA study of Anxiety and Aging that is actively recruiting participants, run by Georgia Institute of Technology. The registered enrollment target is 85 participants, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03896529, a NA study of Anxiety and Aging, is actively recruiting participants, sponsored by Georgia Institute of Technology.
- RECRUITING
- Registry status
- NA
- Development phase
- 85 participants
- Enrollment target
- 1
- Study location
Study Summary
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are marked individual differences in these age-related changes. The investigators' proposal will help characterize factors that contribute to this variability. Participants will be pseudorandomly assigned to stress-manipulated or control groups. The investigators will give both groups a novel immersive navigation task, validated by the PI in healthy young adults. This paradigm gives participants the opportunity to either (a) flexibly draw on spatial memory in order to plan efficient routes to goal locations, or (b) fall back on inefficient, but cognitively less-demanding, stimulus-response associations (i.e., habits). Using neuroimaging and behavioral measures, the investigators' protocol will test whether experimentally-induced stress leads individuals to bring fewer details about future locations to mind when route planning, and whether such restricted prospective thought ultimately biases participants towards relatively inflexible, habitual actions.
Primary Outcome
Probability of taking a virtual navigation shortcut on an fMRI task trial, compared between stress and control groups. Measurement tool: objective categorical measure (no scale) reflecting proportion of trials in which participants traverse the shortcut road or, alternatively, the familiar (longer) road in a virtual environment.
Conditions Studied
Interventions
- BEHAVIORAL Anticipatory psychological stress
Study Locations (1)
Georgia
- Center for Advance Brain Imaging - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2019-09-24 |
| Est. Completion | 2026-03-31 |
| Phase | NA |
What NCT03896529 shows while recruiting
NCT03896529 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (81% lower).
The record links to 3 conditions, with Anxiety appearing as the primary indexed condition, and to 1 intervention - of which Anticipatory psychological stress is the first listed.
NCT03896529 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT03896529 about?
NCT03896529 is a clinical study titled "Neurobiological Mechanisms of Aging and Stress on Prospective Navigation". Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are mark...
What is the current status of trial NCT03896529?
This trial is currently recruiting. It is a NA study. The enrollment target is 85 participants. The study started on 2019-09-24. Estimated completion is 2026-03-31.
What conditions does trial NCT03896529 study?
This clinical trial studies the following conditions: Anxiety, Aging, Memory Impairment.
What interventions are being tested in trial NCT03896529?
The interventions under investigation include: Anticipatory psychological stress (BEHAVIORAL).
Who is sponsoring clinical trial NCT03896529?
This trial is sponsored by Georgia Institute of Technology, which has 24 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03896529 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anxiety
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03896529's enrollment target sits among peer trials
85 190th of 364 higher than 173 of 364 other Anxiety trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anxiety trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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