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NCT06367738 · ClinicalTrials.gov registry record · Phase 1
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
A Phase 1 study of Aging, sponsored by University of California, Berkeley.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06367738: Recruiting Phase 1 study of Aging, sponsored by University of California, Berkeley.
NCT06367738 is a Phase 1 study of Aging that is actively recruiting participants, run by University of California, Berkeley. The registered enrollment target is 40 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06367738, a Phase 1 study of Aging, is actively recruiting participants, sponsored by University of California, Berkeley.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 and 85, will be randomly assigned to receive a dose of psilocybin ranging from a microdose to a moderate-to-high dose. Anatomical magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) will be used to assess changes in brain structure, while functional magnetic resonance imaging (fMRI) will be used to quantify changes in functional brain activity.
Primary Outcome
Diffusion-weighted MRI will be used to measure mean diffusivity in prefrontal cortex and hippocampus.
Conditions Studied
Interventions
- DRUG Psilocybin
Study Locations (1)
California
- University of California, Berkeley - Berkeley
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-11 |
| Est. Completion | 2027-12-30 |
| Phase | Phase 1 |
What NCT06367738 shows while recruiting
NCT06367738 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Psilocybin is the first listed.
NCT06367738 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06367738 about?
NCT06367738 is a clinical study titled "Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults". Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 an...
What is the current status of trial NCT06367738?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-11. Estimated completion is 2027-12-30.
What conditions does trial NCT06367738 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT06367738?
The interventions under investigation include: Psilocybin (DRUG).
Who is sponsoring clinical trial NCT06367738?
This trial is sponsored by University of California, Berkeley, which has 72 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06367738 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06367738's enrollment target sits among peer trials
40 173rd of 262 higher than 84 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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