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NCT06367738 · ClinicalTrials.gov registry record · Phase 1

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

A Phase 1 study of Aging, sponsored by University of California, Berkeley.

Recruiting
Registry status
Phase 1
Development phase
40
Enrollment target
1
Study location

NCT06367738 is a Phase 1 study of Aging that is actively recruiting participants, run by University of California, Berkeley. The registered enrollment target is 40 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06367738, a Phase 1 study of Aging, is actively recruiting participants, sponsored by University of California, Berkeley.

RECRUITING
Registry status
Phase 1
Development phase
40 participants
Enrollment target
1
Study location

Study Summary

Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 and 85, will be randomly assigned to receive a dose of psilocybin ranging from a microdose to a moderate-to-high dose. Anatomical magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) will be used to assess changes in brain structure, while functional magnetic resonance imaging (fMRI) will be used to quantify changes in functional brain activity.

Conditions Studied

Aging

Interventions

  • DRUG Psilocybin

Study Locations (1)

California

  • University of California, Berkeley - Berkeley

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2025-11
Est. Completion 2027-12-30
Phase Phase 1

Sponsor

University of California, Berkeley

72 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06367738

The ClinicalTrials.gov registry entry for NCT06367738 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The listed sponsor is University of California, Berkeley, which has 72 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Psilocybin is the first listed.

NCT06367738 reports 1 study location spanning 1 distinct geographic area - top geographies include California.

Frequently Asked Questions

What is clinical trial NCT06367738 about?

NCT06367738 is a clinical study titled "Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults". Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 an...

What is the current status of trial NCT06367738?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-11. Estimated completion is 2027-12-30.

What conditions does trial NCT06367738 study?

This clinical trial studies the following conditions: Aging.

What interventions are being tested in trial NCT06367738?

The interventions under investigation include: Psilocybin (DRUG).

Who is sponsoring clinical trial NCT06367738?

This trial is sponsored by University of California, Berkeley, which has 72 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06367738 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.