Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT04351113 · ClinicalTrials.gov registry record · NA

Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse

A NA study of Aging and Oxidative Stress, sponsored by Joel Trinity.

Recruiting
Registry status
NA
Development phase
72
Enrollment target
1
Study location

NCT04351113 is a NA study of Aging and Oxidative Stress that is actively recruiting participants, run by Joel Trinity. The registered enrollment target is 72 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT04351113, a NA study of Aging and Oxidative Stress, is actively recruiting participants, sponsored by Joel Trinity.

RECRUITING
Registry status
NA
Development phase
72 participants
Enrollment target
1
Study location

Study Summary

Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and increased mortality. Older adults are a particularly vulnerable population as functional (vascular and skeletal muscle mitochondrial dysfunction) and structural deficits (loss in muscle mass leading to a reduction in strength) are a consequence of the aging process. The combination of inactivity and aging poses an added health threat to these individuals by accelerating the negative impact on vascular and skeletal muscle function and dysfunction. The underlying factors leading to vascular and skeletal muscle dysfunction are unknown, but have been linked to increases in oxidative stress. Additionally, there is a lack of understanding of how vascular function is impacted by inactivity in humans and how these changes are related to skeletal muscle function. It is our goal to investigate the mechanisms that contribute to disuse muscle atrophy and vascular dysfunction in order to diminish their negative impact, and preserve vascular and skeletal muscle function across all the lifespan.

Conditions Studied

Aging Oxidative Stress Skeletal Muscle Vascular Endothelium Antioxidants

Interventions

  • OTHER Placebo
  • DIETARY_SUPPLEMENT MITO-AO
  • DIETARY_SUPPLEMENT PB-125
  • OTHER Passive Leg Movement (PLM)
  • OTHER Plantar flexion

Study Locations (1)

Utah

  • VA Medical Center - Salt Lake City

Trial Details

FieldValue
Enrollment Target 72 participants
Start Date 2019-09-01
Est. Completion 2025-12-31
Phase NA

Sponsor

Joel Trinity

1 total trials

Interested in This Trial?

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04351113

The ClinicalTrials.gov registry entry for NCT04351113 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The listed sponsor is Joel Trinity, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 5 conditions, with Aging appearing as the primary indexed condition, and to 5 interventions - of which Placebo is the first listed.

NCT04351113 reports 1 study location spanning 1 distinct geographic area - top geographies include Utah.

Frequently Asked Questions

What is clinical trial NCT04351113 about?

NCT04351113 is a clinical study titled "Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse". Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and increased mortality. Older adults are a particularly vulnerable population a...

What is the current status of trial NCT04351113?

This trial is currently recruiting. It is a NA study. The enrollment target is 72 participants. The study started on 2019-09-01. Estimated completion is 2025-12-31.

What conditions does trial NCT04351113 study?

This clinical trial studies the following conditions: Aging, Oxidative Stress, Skeletal Muscle, Vascular Endothelium, Antioxidants.

What interventions are being tested in trial NCT04351113?

The interventions under investigation include: Placebo (OTHER), MITO-AO (DIETARY_SUPPLEMENT), PB-125 (DIETARY_SUPPLEMENT), Passive Leg Movement (PLM) (OTHER), Plantar flexion (OTHER).

Who is sponsoring clinical trial NCT04351113?

This trial is sponsored by Joel Trinity, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04351113 being conducted?

This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Aging

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Explore more on PlainTrial

Aging

All registered trials for this condition

Oxidative Stress

All registered trials for this condition

Utah

All trials with a study site in Utah

Recruiting now

Find trials open to new participants near you

Rankings

Top sponsors, conditions, and phases

Read our methodology - how this data is sourced, computed, and verified.

Related

Browse all → | Rankings →
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.