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NCT05808686 · ClinicalTrials.gov registry record · Phase 2
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
A Phase 2 study of Aging and Endothelial Dysfunction, sponsored by Medical College of Wisconsin.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05808686: Recruiting Phase 2 study of Aging and Endothelial Dysfunction, sponsored by Medical College of Wisconsin.
NCT05808686 is a Phase 2 study of Aging and Endothelial Dysfunction that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 60 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05808686, a Phase 2 study of Aging and Endothelial Dysfunction, is actively recruiting participants, sponsored by Medical College of Wisconsin.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.
Primary Outcome
Cutaneous vascular conductance in response to acetylcholine infusion will be calculated as laser Doppler flux / mean arterial pressure
Conditions Studied
Interventions
- OTHER Ischemic Conditioning
Study Locations (1)
Wisconsin
- Froedtert Hospital - Wauwatosa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-05-02 |
| Est. Completion | 2029-12 |
| Phase | Phase 2 |
What NCT05808686 shows while recruiting
NCT05808686 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Ischemic Conditioning is the first listed.
NCT05808686 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05808686 about?
NCT05808686 is a clinical study titled "Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals". The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-bas...
What is the current status of trial NCT05808686?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2023-05-02. Estimated completion is 2029-12.
What conditions does trial NCT05808686 study?
This clinical trial studies the following conditions: Aging, Endothelial Dysfunction, Fragility.
What interventions are being tested in trial NCT05808686?
The interventions under investigation include: Ischemic Conditioning (OTHER).
Who is sponsoring clinical trial NCT05808686?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05808686 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05808686's enrollment target sits among peer trials
60 137th of 262 higher than 120 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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