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ClinicalTrials.gov 9 recruiting now official registry

Advanced Non-Small-Cell Lung Cancer clinical trials

9 of 23 indexed Advanced Non-Small-Cell Lung Cancer trials are currently recruiting.

23 US clinical trials · 9 currently recruiting

Advanced Non-Small-Cell Lung Cancer is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Bayer, running 3 of these trials.

The research picture

Advanced Non-Small-Cell Lung Cancer has 23 registered US clinical trials, 9 of them open to new participants right now, about 39% of the total.

9
recruiting participants now
39%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: Bayer
Phase 16Phase 211Phase 35

Active & Recent Trials

23 total, page 1 of 1

RECRUITING Phase 3 1,410 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pfizer

NCT07222566

RECRUITING Phase 2 806 participants

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Mirati Therapeutics

NCT04613596

RECRUITING Phase 3 480 participants

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

ArriVent BioPharma

NCT07185997

RECRUITING Phase 1 310 participants

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Pfizer

NCT07090499

RECRUITING Phase 3 278 participants

A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Bayer

NCT06452277

RECRUITING Phase 2 85 participants

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT02133196

RECRUITING Phase 2 40 participants

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Virginia Commonwealth University

NCT06731413

RECRUITING Phase 1 23 participants

Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT05777603

RECRUITING Phase 2 20 participants

Imaging Advanced NSCLC Patients Undergoing PD-1/PD-L1 Directed Therapy Using [18F]-FARAG

CellSight Technologies

NCT06107374

ACTIVE NOT RECRUITING 1,000 participants

Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) Patients

Regeneron Pharmaceuticals

NCT06269133

ACTIVE NOT RECRUITING Phase 2 850 participants

A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)

Regeneron Pharmaceuticals

NCT05785767

ACTIVE NOT RECRUITING Phase 3 453 participants

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Mirati Therapeutics

NCT04685135

ACTIVE NOT RECRUITING Phase 2 400 participants

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

Gilead Sciences

NCT05676931

ACTIVE NOT RECRUITING Phase 3 398 participants

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

ArriVent BioPharma

NCT05607550

ACTIVE NOT RECRUITING Phase 1 370 participants

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Bayer

NCT05099172

ACTIVE NOT RECRUITING Phase 1 344 participants

AZD9291 in Combination With Ascending Doses of Novel Therapeutics

AstraZeneca

NCT02143466

ACTIVE NOT RECRUITING Phase 1 160 participants

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

ArriVent BioPharma

NCT05364073

ACTIVE NOT RECRUITING Phase 2 159 participants

The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer

Yale University

NCT04699123

ACTIVE NOT RECRUITING Phase 2 120 participants

A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer

Fujifilm Pharmaceuticals U.S.A.

NCT05318573

ACTIVE NOT RECRUITING Phase 2 51 participants

A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)

Regeneron Pharmaceuticals

NCT05557591

COMPLETED Phase 2 597 participants

Phase II Study of Brivanib (BMS-582664) to Treat Multiple Tumor Types

Bristol-Myers Squibb

NCT00633789

COMPLETED Phase 2 43 participants

Erlotinib (Tarceva (Trademark), OSI-774) in Treating Patients With Advanced Non-Small Cell Lung Cancer

OSI Pharmaceuticals

NCT00072631

COMPLETED Phase 1 21 participants

A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants

Bayer

NCT06378658

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 11
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Non-Small-Cell Lung Cancer Trial Landscape

23 indexed Advanced Non-Small-Cell Lung Cancer studies · 9 recruiting (39%).

Phase mix: 5 late (III/IV) vs 17 early (I/II).

Top sponsor: Bayer (3 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Non-Small-Cell Lung Cancer?

PlainTrial tracks 23 US clinical trials for Advanced Non-Small-Cell Lung Cancer, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Non-Small-Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.