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NCT04716803 · ClinicalTrials.gov registry record · NA

Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis

A NA study of Osteoarthritis, Knee, sponsored by University of California, San Diego.

Recruiting
Registry status
NA
Development phase
10
Enrollment target
1
Study location

NCT04716803: Recruiting NA study of Osteoarthritis, Knee, sponsored by University of California, San Diego.

NCT04716803 is a NA study of Osteoarthritis, Knee that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 10 participants, below the 498-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04716803, a NA study of Osteoarthritis, Knee, is actively recruiting participants, sponsored by University of California, San Diego.

RECRUITING
Registry status
NA
Development phase
10 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a stem cell-based therapy that has been reported to preserve or improve the structure of joints. The Angel System is the device used in this study to concentrate bone marrow from the patient and is intended to separate a mixture of blood and bone marrow and collect plasma rich platelets preoperative to a surgical procedure. The goal of this study is to identify whether BMAC can be an effective and safe treatment for patients with osteoarthritis of the knee.

Primary Outcome

The number of life-threatening severe adverse events as determined by the standard FDA guidelines for adverse events that are deemed to be related to autologous BMAC concentrated by the Angel System and delivered via intra-articular injection into the knee.

Conditions Studied

Osteoarthritis, Knee

Interventions

  • BIOLOGICAL Bone Marrow Aspirate Concentrate
  • DEVICE Angel Concentrated Platelet Rich Plasma (cPRP) System

Study Locations (1)

California

  • University of California San Diego Koman Outpatient Pavilion - La Jolla

Trial Details

FieldValue
Enrollment Target 10 participants
Start Date 2020-07-08
Est. Completion 2023-12-31
Phase NA
University of California, San Diego

775 total trials

What NCT04716803 shows while recruiting

NCT04716803 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 498-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (98% lower).

The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 2 interventions - of which Bone Marrow Aspirate Concentrate is the first listed.

NCT04716803 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT04716803 about?

NCT04716803 is a clinical study titled "Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis". The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a stem cell-based therapy that has been reported to ...

What is the current status of trial NCT04716803?

This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2020-07-08. Estimated completion is 2023-12-31.

What conditions does trial NCT04716803 study?

This clinical trial studies the following conditions: Osteoarthritis, Knee.

What interventions are being tested in trial NCT04716803?

The interventions under investigation include: Bone Marrow Aspirate Concentrate (BIOLOGICAL), Angel Concentrated Platelet Rich Plasma (cPRP) System (DEVICE).

Who is sponsoring clinical trial NCT04716803?

This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04716803 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Osteoarthritis, Knee

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04716803's enrollment target sits among peer trials

10 110th of 112 higher than 2 of 112 other Osteoarthritis, Knee trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04716803

Source: ClinicalTrials.gov NCT04716803, the US trial registry maintained by the National Library of Medicine. NCT04716803 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.