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NCT04875052 · ClinicalTrials.gov registry record · NA

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

A NA study of Osteoarthritis, Knee and Anterior Cruciate Ligament Injuries, sponsored by University of North Carolina, Chapel Hill.

Recruiting
Registry status
NA
Development phase
114
Enrollment target
2
Study locations

NCT04875052 is a NA study of Osteoarthritis, Knee and Anterior Cruciate Ligament Injuries that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 114 participants, below the 579-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (80% lower). The trial reports 2 study locations across 1 state.

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The verdict

NCT04875052, a NA study of Osteoarthritis, Knee and Anterior Cruciate Ligament Injuries, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.

RECRUITING
Registry status
NA
Development phase
114 participants
Enrollment target
2
Study locations

Study Summary

The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). The main objectives are to compare the effects of Standard rehabilitation vs. rehabilitation that includes whole body vibration (WBV) or local muscle vibration (LMV) on: * Quadriceps muscle function * Gait biomechanics linked to post-traumatic knee osteoarthritis development * Patient self-report outcomes * MRI indicators of knee joint health and muscle quality * Landing biomechanics linked to secondary ACL injury risk * Evidence-based return-to-physical-activity criteria Participants will be assigned to 1 of 3 groups (standard rehabilitation, standard rehabilitation + WBV, or standard rehabilitation + LMV) and will complete assessments of quadriceps function, gait biomechanics, landing biomechanics, functional ability, patient-report outcomes, and MRI 1, 6, and 12 months after ACLR. Researchers will compare the groups to see if vibration embedded in ACLR rehabilitation improves joint health outcomes.

Conditions Studied

Osteoarthritis, Knee Anterior Cruciate Ligament Injuries Post-traumatic Osteoarthritis Quadriceps Muscle Atrophy

Interventions

  • DEVICE Experimental: Whole Body Vibration
  • DEVICE Experimental: Local Muscle Vibration
  • OTHER Standard ACL Rehabilitation

Study Locations (2)

North Carolina

  • MOTION Science Institute - Chapel Hill
  • Womack Army Medical Center - Chapel Hill

Trial Details

FieldValue
Enrollment Target 114 participants
Start Date 2021-01-11
Est. Completion 2026-08
Phase NA

Sponsor

University of North Carolina, Chapel Hill

1,109 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04875052

The ClinicalTrials.gov registry entry for NCT04875052 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 114 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 579-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (80% lower). The listed sponsor is University of North Carolina, Chapel Hill, which has 1,109 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 3 interventions - of which Experimental: Whole Body Vibration is the first listed.

NCT04875052 reports 2 study locations spanning 1 distinct geographic area - top geographies include North Carolina.

Frequently Asked Questions

What is clinical trial NCT04875052 about?

NCT04875052 is a clinical study titled "Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury". The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). T...

What is the current status of trial NCT04875052?

This trial is currently recruiting. It is a NA study. The enrollment target is 114 participants. The study started on 2021-01-11. Estimated completion is 2026-08.

What conditions does trial NCT04875052 study?

This clinical trial studies the following conditions: Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy.

What interventions are being tested in trial NCT04875052?

The interventions under investigation include: Experimental: Whole Body Vibration (DEVICE), Experimental: Local Muscle Vibration (DEVICE), Standard ACL Rehabilitation (OTHER).

Who is sponsoring clinical trial NCT04875052?

This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04875052 being conducted?

This trial has 2 study locations across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.