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NCT06038240 · ClinicalTrials.gov registry record · NA
Optimizing Pain Self-Management in Total Knee Arthroplasty
A NA study of Surgery and Osteoarthritis, Knee, sponsored by University of Virginia.
- Recruiting
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT06038240: Recruiting NA study of Surgery and Osteoarthritis, Knee, sponsored by University of Virginia.
NCT06038240 is a NA study of Surgery and Osteoarthritis, Knee that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 150 participants, below the 52,850-participant average among 120 other Surgery trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06038240, a NA study of Surgery and Osteoarthritis, Knee, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward system dysfunction as a chronic pain mechanism - is optimally suited to reduce postsurgical pain and augment reward system functioning relative to a Pain Self-Management and Education (PSME) condition. We will randomize 150 patients with KOA undergoing unilateral TKA to a brief, 4-session (20-30 minutes each) course of Savoring Meditation (SM; n = 75) or PSME (n = 75) delivered remotely by trained interventionists in a one-on-one format. We will assess pain and as well as pain-related risk and protective factors both via questionnaire and via weeklong ecological momentary assessment (EMA) data bursts on the following schedule: baseline, post-surgery, and 3-month follow-up. In addition, participants will attend laboratory testing sessions at baseline and 6-weeks post-surgery, during which affective pain modulation and electroencephalographic (EEG) brain biomarkers associated with pain and affect will be recorded. Participants in SM be encouraged to practice their savoring for 5 minutes/day during the week following surgery, as well as to use it to manage pain flares in a self-directed manner.
Primary Outcome
Average pain intensity on numeric rating scale (range of 0-100; higher scores indicate greater pain), aggregated across Ecological Momentary Assessment observations
Conditions Studied
Interventions
- BEHAVIORAL Savoring Meditation
- BEHAVIORAL Pain Self-Management and Education
Study Locations (1)
Virginia
- Fontaine Research Park - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2023-11-27 |
| Est. Completion | 2027-09 |
| Phase | NA |
What NCT06038240 shows while recruiting
NCT06038240 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 52,850-participant average among 120 other Surgery trials with a reported enrollment target (100% lower).
The record links to 3 conditions, with Surgery appearing as the primary indexed condition, and to 2 interventions - of which Savoring Meditation is the first listed.
NCT06038240 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT06038240 about?
NCT06038240 is a clinical study titled "Optimizing Pain Self-Management in Total Knee Arthroplasty". The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emo...
What is the current status of trial NCT06038240?
This trial is currently recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2023-11-27. Estimated completion is 2027-09.
What conditions does trial NCT06038240 study?
This clinical trial studies the following conditions: Surgery, Osteoarthritis, Knee, Knee Pain Chronic.
What interventions are being tested in trial NCT06038240?
The interventions under investigation include: Savoring Meditation (BEHAVIORAL), Pain Self-Management and Education (BEHAVIORAL).
Who is sponsoring clinical trial NCT06038240?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06038240 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06038240's enrollment target sits among peer trials
150 46th of 120 higher than 75 of 120 other Surgery trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgery trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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