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NCT05946044 · ClinicalTrials.gov registry record · NA

The Osteoarthritis Prevention Study

A NA study of Osteoarthritis, Knee, sponsored by Wake Forest University.

Recruiting
Registry status
NA
Development phase
1,230
Enrollment target
4
Study locations

NCT05946044 is a NA study of Osteoarthritis, Knee that is actively recruiting participants, run by Wake Forest University. The registered enrollment target is 1,230 participants, above the 566-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (117% higher). The trial reports 4 study locations across 3 states.

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The verdict

NCT05946044, a NA study of Osteoarthritis, Knee, is actively recruiting participants, sponsored by Wake Forest University.

RECRUITING
Registry status
NA
Development phase
1,230 participants
Enrollment target
4
Study locations

Study Summary

The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.

Conditions Studied

Osteoarthritis, Knee

Interventions

  • BEHAVIORAL Diet and Exercise

Study Locations (4)

North Carolina

  • University of North Carolina at Chapel Hill - Chapel Hill
  • Wake Forest University - Winston-Salem

Massachusetts

  • Brigham and Women's Hospital - Boston

Other

  • University of Sydney - Sydney

Trial Details

FieldValue
Enrollment Target 1,230 participants
Start Date 2024-03-21
Est. Completion 2029-07-31
Phase NA

Sponsor

Wake Forest University

100 total trials

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What the Registry Record Tells You About NCT05946044

The ClinicalTrials.gov registry entry for NCT05946044 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 1,230 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 566-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (117% higher). The listed sponsor is Wake Forest University, which has 100 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Diet and Exercise is the first listed.

NCT05946044 reports 4 study locations spanning 3 distinct geographic areas - top geographies include North Carolina, Massachusetts, Other.

Frequently Asked Questions

What is clinical trial NCT05946044 about?

NCT05946044 is a clinical study titled "The Osteoarthritis Prevention Study". The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a di...

What is the current status of trial NCT05946044?

This trial is currently recruiting. It is a NA study. The enrollment target is 1,230 participants. The study started on 2024-03-21. Estimated completion is 2029-07-31.

What conditions does trial NCT05946044 study?

This clinical trial studies the following conditions: Osteoarthritis, Knee.

What interventions are being tested in trial NCT05946044?

The interventions under investigation include: Diet and Exercise (BEHAVIORAL).

Who is sponsoring clinical trial NCT05946044?

This trial is sponsored by Wake Forest University, which has 100 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05946044 being conducted?

This trial has 4 study locations across Massachusetts, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.