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NCT05946044 · ClinicalTrials.gov registry record · NA
The Osteoarthritis Prevention Study
A NA study of Osteoarthritis, Knee, sponsored by Wake Forest University.
- Recruiting
- Registry status
- NA
- Development phase
- 1,230
- Enrollment target
- 4
- Study locations
NCT05946044: Recruiting NA study of Osteoarthritis, Knee, sponsored by Wake Forest University.
NCT05946044 is a NA study of Osteoarthritis, Knee that is actively recruiting participants, run by Wake Forest University. The registered enrollment target is 1,230 participants, above the 487-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (153% higher). The trial reports 4 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05946044, a NA study of Osteoarthritis, Knee, is actively recruiting participants, sponsored by Wake Forest University.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,230 participants
- Enrollment target
- 4
- Study locations
Study Summary
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.
Primary Outcome
Compare the effects of a 48-month intervention of dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural (MRI) knee OA. Assessed using the MRI Osteoarthritis Knee Score (MOAKS). The MOAKS evaluates degenerative changes in the knee, including the location and severity of osteophyte formation, bone marrow lesions, and cartilage loss. The MOAKS classification system of osteophytes has grades ranging from 0 (none) to 3 (la
Conditions Studied
Interventions
- BEHAVIORAL Diet and Exercise
Study Locations (4)
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
- Wake Forest University - Winston-Salem
Massachusetts
- Brigham and Women's Hospital - Boston
Other
- University of Sydney - Sydney
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,230 participants |
| Start Date | 2024-03-21 |
| Est. Completion | 2029-07-31 |
| Phase | NA |
What NCT05946044 shows while recruiting
NCT05946044 is an interventional study that assigns participants to a tested intervention. Its 1,230 participants enrollment target places it among the larger protocols in the corpus, above the 487-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (153% higher).
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Diet and Exercise is the first listed.
NCT05946044 reports a single indexed study location in North Carolina, Massachusetts, Other.
Frequently Asked Questions
What is clinical trial NCT05946044 about?
NCT05946044 is a clinical study titled "The Osteoarthritis Prevention Study". The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a di...
What is the current status of trial NCT05946044?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,230 participants. The study started on 2024-03-21. Estimated completion is 2029-07-31.
What conditions does trial NCT05946044 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT05946044?
The interventions under investigation include: Diet and Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT05946044?
This trial is sponsored by Wake Forest University, which has 100 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05946044 being conducted?
This trial has 4 study locations across Massachusetts, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05946044's enrollment target sits among peer trials
1,230 7th of 112 higher than 106 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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