Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits. Addendum (2) is optional and available to approximately 500 participants to continue treatment with retatrutide for up to an additional 24 weeks.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Retatrutide
Study Locations (20)
Florida
- Teradan Clinical Trials, LLC — Brandon
- Suncoast Research Group — Miami
- New Horizon Research Center — Miami
- Clinical Neuroscience Solutions — Orlando
- Progressive Medical Research — Port Orange
California
- Neuro-Pain Medical Center — Fresno
- Valley Research — Fresno
- Artemis Institute for Clinical Research — San Diego
Arizona
- Central Phoenix Medical Clinic — Phoenix
- Arizona Research Center — Phoenix
Connecticut
- Yale University School of Medicine — New Haven
- Chase Medical Research, LLC — Waterbury
Georgia
- NeuroTrials Research Inc — Atlanta
- North Georgia Clinical Research — Woodstock
Illinois
- Northwestern University — Chicago
- Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative — Springfield
Arkansas
- Medical Investigations — Little Rock
Colorado
- University of Colorado Anschutz Medical Campus — Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,300 participants |
| Start Date | 2023-07-10 |
| Est. Completion | 2026-05 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05929066
The ClinicalTrials.gov registry entry for NCT05929066 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05929066 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05929066 about?
NCT05929066 is a clinical study titled "A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight". The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This...
What is the current status of trial NCT05929066?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 2,300 participants. The study started on 2023-07-10. Estimated completion is 2026-05.
What conditions does trial NCT05929066 study?
This clinical trial studies the following conditions: Obesity, Overweight, Obstructive Sleep Apnea, Osteoarthritis, Knee. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05929066?
The interventions under investigation include: Placebo (DRUG), Retatrutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05929066?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05929066 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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