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Osteoarthritis, Knee: full-pipeline trial registry
45 of 115 indexed Osteoarthritis, Knee trials are currently recruiting.
Corpus placement: #110 of 28,707 conditions by registered trial count.
115 US clinical trials · 45 currently recruiting · #110 of 28,707 conditions by registered trial count
Osteoarthritis, Knee: 115 US clinical trials tracked, 45 recruiting.
Osteoarthritis, Knee is the subject of 115 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 34 in Phase 1-2 (earlier-stage). The most active sponsor is Regeneron Pharmaceuticals, running 4 of these trials.
Enrollment posture brief
Registry condition osteoarthritis-knee
OPEN 45 | RECR 39% | LATE 23 | EARLY 34 | RANK #110 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Advanced Non-Small-Cell Lung Cancer (39% recruiting · 23 trials)
Osteoarthritis, Knee lists 45 open slots (39% of 115 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis, Knee on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis, Knee is recruiting above its size-band peers.
45 of 115 indexed trials (39.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis, Knee trials is spread across many organizations.
Regeneron Pharmaceuticals accounts for 4 of 115 trials (3.5%). 90 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis, Knee enrolment sits around 120 participants.
Median target enrolment is 120 among the 113 trials that report a genuine target (sentinel values excluded). 44 of those (38.9%) plan for fewer than 100 participants.
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Osteoarthritis, Knee research is mostly interventional.
104 interventional and 11 observational studies make up this index (90.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
115 total, page 2 of 3
Prospective Post Approval Clinical Follow-Up Study of the Commercially Available U2 Knee™ System - "U-Propel Study"
United Orthopedic Corporation
NCT03060057
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT06121882
JOURNEY™ II CR Total Knee System
Smith & Nephew
NCT02440672
Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty
Prisma Health-Midlands
NCT05678231
TracPatch in Total Knee Arthroplasty
University of Miami
NCT03466476
Corticosteroid Meniscectomy Randomized Trial
The Cleveland Clinic
NCT04641351
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
Hospital for Special Surgery, New York
NCT04082533
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
GID BIO
NCT04440189
Prospective Randomized Study of Cementless vs Cemented UKA
JIS Research Institute
NCT05377450
Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Steadman Philippon Research Institute
NCT04815902
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
CrannMed
NCT06550024
Moving Well for Total Knee Arthroplasty (TKA)
Weill Medical College of Cornell University
NCT05217420
Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the Knee
Pacira Pharmaceuticals
NCT04119687
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Genascence Corporation
NCT05835895
Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction
Steadman Philippon Research Institute
NCT04205656
Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
Tufts University
NCT05505552
Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis
Northwestern University
NCT05430230
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
Zimmer Biomet
NCT03737149
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
Regeneron Pharmaceuticals
NCT03161093
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
Regeneron Pharmaceuticals
NCT03304379
Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip
US Department of Veterans Affairs
NCT00105677
A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS
Restor3D
NCT03152357
Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study
DePuy Orthopaedics
NCT00289133
An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the Treatment of Osteoarthritis of the Knee
IDEA
NCT00211549
Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
Nuvo Research
NCT00108992
Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT00643799
Efficacy and Safety of Celecoxib Versus Placebo in the Treatment of Patients With Osteoarthritis of the Knee Who Were Unresponsive to Naproxen and Ibuprofen
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT00640627
Civamide in OA of the Knee(s)
Winston Laboratories
NCT00077935
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
Centrexion Therapeutics
NCT03660943
Melatonin Use After Primary Total Joint Arthroplasty
NYU Langone Health
NCT04795336
Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
ZetrOZ
NCT05882812
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
University of Texas at Austin
NCT04805554
Periosteal Stimulation for Knee Osteoarthritis
US Department of Veterans Affairs
NCT00865046
Tidal Lavage in Knee Osteoarthritis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00000424
Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee
Regeneron Pharmaceuticals
NCT03691974
Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT05660772
Vitamin D to Slow Progression of Knee Osteoarthritis
Tufts Medical Center
NCT00306774
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
Pacira Pharmaceuticals
NCT03529942
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
ZARS Pharma
NCT00108810
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
Rush University Medical Center
NCT02588872
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
Henry Ford Health System
NCT01370460
To Assess the Patients' Ability to Self-Administer Fasinumab
Regeneron Pharmaceuticals
NCT03491904
Celution Prepared Adipose Derived Regenerative Cells in the Treatment of Osteoarthritis of the Knee
Cytori Therapeutics
NCT02326961
An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks
Bayer
NCT03556787
Calypso Knee System Clinical Study
Moximed
NCT03671213
Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation
DePuy Orthopaedics
NCT01108237
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
Baylor College of Medicine
NCT04269239
Clinical Outcomes With Omni Apex Ultracongruent Knee System
Spokane Joint Replacement Center
NCT01367938
Is Botox Effective in Relieving Pain From Knee Osteoarthritis?
Mayo Clinic
NCT00279903
MobilWise: Mobile Phone Remote Coaching After Worksite Joint ADventure Exposure
Rush University Medical Center
NCT02950090
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 17 |
| Phase 2 | 17 |
| Phase 3 | 14 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis, Knee records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis, Knee trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis, Knee page
115 registered trials, 45 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 45 Osteoarthritis, Knee trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Regeneron Pharmaceuticals sponsors the most Osteoarthritis, Knee trials on record, review their full trial history before evaluating a specific study. See Regeneron Pharmaceuticals's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis, Knee condition card totals 115 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.