Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Opioid Use: full-pipeline trial registry
46 of 106 indexed Opioid Use trials are currently recruiting.
Corpus placement: #122 of 28,707 conditions by registered trial count.
106 US clinical trials · 46 currently recruiting · #122 of 28,707 conditions by registered trial count
Opioid Use: 106 US clinical trials tracked, 46 recruiting.
Opioid Use is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 7 of these trials.
Enrollment posture brief
Registry condition opioid-use
OPEN 46 | RECR 43% | LATE 20 | EARLY 14 | RANK #122 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Healthy Volunteer (43% recruiting · 113 trials)
Opioid Use lists 46 open slots (43% of 106 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Use is recruiting above its size-band peers.
46 of 106 indexed trials (43.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Use trials is spread across many organizations.
Hospital for Special Surgery, New York accounts for 7 of 106 trials (6.6%). 69 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Use enrolment sits around 144 participants.
Median target enrolment is 144 among the 106 trials that report a genuine target (sentinel values excluded). 38 of those (35.8%) plan for fewer than 100 participants.
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Opioid Use research is mostly interventional.
95 interventional and 11 observational studies make up this index (89.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
106 total, page 1 of 3
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
University of Washington
NCT06768814
Reducing Opioid Mortality in Illinois
University of Chicago
NCT04925427
Machine-Learning Prediction and Reducing Overdoses With EHR Nudges
University of Pittsburgh
NCT06806163
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
Brigham and Women's Hospital
NCT06466941
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Wake Forest University Health Sciences
NCT04927143
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
Senthil Sadhasivam
NCT05380531
Culturally Responsive Community Driven Substance Use Recovery for Black and Latinx Population
Yale University
NCT05260047
Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment
Emory University
NCT05711056
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
Rutgers, The State University of New Jersey
NCT06032559
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
Rutgers, The State University of New Jersey
NCT06033599
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
Johns Hopkins University
NCT06103370
PRIDE III Prison Interventions and HIV Prevention Collaboration
Yale University
NCT06962033
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
Jacques E. Chelly
NCT05506878
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
Treating Polysubstance Use Using a Novel Digital Technology
Friends Research Institute
NCT05766631
fMRI and Opioid Abstinence
Yale University
NCT06651333
Sex Hormones, Postoperative Pain and Opioid Use
Washington University School of Medicine
NCT06023225
Hip Arthroscopy Postoperative Opioid Demands
Rush University Medical Center
NCT04094701
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
University of South Florida
NCT06345872
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York
NCT05058287
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Brigham and Women's Hospital
NCT04798469
Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal
University of Pennsylvania
NCT05995535
Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain
University of Utah
NCT05607381
Sleep Disordered Breathing With Opioid Use
VA Office of Research and Development
NCT05589753
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
Sanford Health
NCT03858231
Neuroimaging of Opioid Phase (OPAL)
Duke University
NCT05905419
Opioid Dispensing Device for Post-Operative Pain in Cancer Patients
Columbia University
NCT05585788
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Columbia University
NCT06456268
Opioid Use After Laparoscopic Salpingectomy
Johns Hopkins University
NCT06434233
Mindfulness in Endometrial and Cervical Cancer
St. Louis University
NCT04512144
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Emory University
NCT05834478
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
Virginia Commonwealth University
NCT06981195
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
NCT06903819
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Massachusetts General Hospital
NCT04912531
rTMS as Add on Treatment for Substance Use Disorders
Yale University
NCT06963476
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
Henry Ford Health System
NCT06113211
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
University of Massachusetts, Worcester
NCT06528288
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05981105
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
University of Notre Dame
NCT07342504
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
St. Louis University
NCT03823534
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
University of North Carolina, Chapel Hill
NCT07213635
QL vs LAI for Palatoplasty
Medical University of South Carolina
NCT06420336
Opioid Dispenser for Microdiscectomy/Laminectomy
Hospital for Special Surgery, New York
NCT06358040
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
University of Texas Southwestern Medical Center
NCT06100172
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The University of Texas Medical Branch, Galveston
NCT07294118
Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery
University of Tennessee
NCT06532708
Facilitating Opioid Care Connections
New York State Psychiatric Institute
NCT04216719
Opioid Analgesic Reduction Study
Rutgers, The State University of New Jersey
NCT04452344
Integrated HIV Prevention and HCV Care for PWID
Columbia University
NCT03981445
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
Johns Hopkins University
NCT04601064
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 8 |
| Phase 4 | 12 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Use page
106 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Opioid Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Hospital for Special Surgery, New York sponsors the most Opioid Use trials on record, review their full trial history before evaluating a specific study. See Hospital for Special Surgery, New York's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Use condition card totals 106 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.