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ClinicalTrials.gov 46 recruiting now official registry

Cognitive Impairment clinical trials

46 of 106 indexed Cognitive Impairment trials are currently recruiting.

106 US clinical trials · 46 currently recruiting

Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.

The research picture

Cognitive Impairment has 106 registered US clinical trials, 46 of them open to new participants right now, about 43% of the total.

46
recruiting participants now
43%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
7
top sponsor: University of Alabama at Birmingham
Phase 12Phase 210Phase 34Phase 42

Active & Recent Trials

106 total, page 1 of 3

RECRUITING NA 45,257 participants

Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

Northwestern University

NCT05607732

RECRUITING NA 6,600 participants

5-Cog 2.0: A Pragmatic Clinical Trial

Albert Einstein College of Medicine

NCT05515224

RECRUITING 2,000 participants

Pacific Northwest Udall Center (PANUC) Clinical Core

University of Washington

NCT01720810

RECRUITING NA 440 participants

Evaluating the Efficacy of the Pain Identification and Communication Toolkit

Weill Medical College of Cornell University

NCT06168604

RECRUITING Phase 3 300 participants

Biomarker Exploration in Aging, Cognition and Neurodegeneration

University of California, Irvine

NCT03860857

RECRUITING NA 300 participants

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

Johns Hopkins University

NCT06930560

RECRUITING 250 participants

Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

Stanford University

NCT03839784

RECRUITING NA 216 participants

A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Arizona State University

NCT05877196

RECRUITING NA 200 participants

Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study

HudsonAlpha Institute for Biotechnology

NCT07146412

RECRUITING NA 176 participants

Mind Your Heart-II

The Miriam Hospital

NCT05431192

RECRUITING NA 150 participants

Gerofit and Cognition

VA Office of Research and Development

NCT06107842

RECRUITING NA 150 participants

Early Age-Related Hearing Loss Investigation (EARHLI)

Columbia University

NCT06174038

RECRUITING 120 participants

Brain Health in Breast Cancer Survivors

Jonsson Comprehensive Cancer Center

NCT04297020

RECRUITING Phase 2 120 participants

Cognitive Remediation Intervention to Prepare for Transition of Care

University of Alabama at Birmingham

NCT05336201

RECRUITING Phase 4 120 participants

Remimazolam for Cataract Surgery

University of California, Los Angeles

NCT05980117

RECRUITING NA 110 participants

Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV

University of Alabama at Birmingham

NCT06013579

RECRUITING NA 110 participants

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

University of California, San Francisco

NCT06077292

RECRUITING NA 110 participants

A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

University of Florida

NCT05998031

RECRUITING Phase 2 100 participants

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

Mclean Hospital

NCT06191965

RECRUITING NA 100 participants

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

University of Washington

NCT06411561

RECRUITING NA 100 participants

Cognitive Screening Made Easy for PCPs - Administrative Supplement

University of Texas at Austin

NCT06928298

RECRUITING NA 100 participants

A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

Weill Medical College of Cornell University

NCT05081596

RECRUITING NA 90 participants

Amygdala Memory Enhancement

Washington University School of Medicine

NCT05065450

RECRUITING Phase 2 90 participants

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

UNC Lineberger Comprehensive Cancer Center

NCT06727773

RECRUITING NA 88 participants

Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

Ohio State University

NCT06223672

RECRUITING Phase 2 82 participants

Study of ALTO-101 in Patients With Schizophrenia

Alto Neuroscience

NCT06502964

RECRUITING NA 80 participants

Diet and Cognitive Training in Hematologic Cancer Survivors

University of Alabama at Birmingham

NCT05708716

RECRUITING NA 80 participants

Cancer and Mild Cognitive Impairment Dyadic Intervention

Duke University

NCT05144516

RECRUITING Phase 1 72 participants

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

St. Jude Children's Research Hospital

NCT07226219

RECRUITING NA 70 participants

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

University of Pennsylvania

NCT04897334

RECRUITING NA 60 participants

TDCS to Improve Post-Stroke Cognitive Impairment

Johns Hopkins University

NCT05195398

RECRUITING NA 60 participants

Cognitive Training Intervention and Attitudes Towards Genetics

University of Alabama at Birmingham

NCT03094026

RECRUITING 60 participants

Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

Joseph McCollom

NCT05014399

RECRUITING NA 50 participants

Train Your Brain SC: Exercise for People With Mild-moderate Cognitive Impairments

University of South Carolina

NCT06799429

RECRUITING NA 50 participants

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

State University of New York at Buffalo

NCT05500170

RECRUITING NA 45 participants

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

Brigham and Women's Hospital

NCT06989619

RECRUITING NA 40 participants

A Study of Healthy Microbiome, Healthy Mind

Mayo Clinic

NCT06020703

RECRUITING NA 40 participants

Community Health Worker-Led Transition Support for Persons Living With Dementia and Caregivers

University of Texas at Austin

NCT06831318

RECRUITING 40 participants

Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

Mclean Hospital

NCT05245903

RECRUITING NA 30 participants

Long COVID Brain Fog: Cognitive Rehabilitation Trial

University of Alabama at Birmingham

NCT06095297

RECRUITING 30 participants

Investigating Dynamic Interactions in Distributed Cognitive Control Networks

University of Alabama at Birmingham

NCT05927974

RECRUITING NA 24 participants

A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI

Kessler Foundation

NCT06238492

RECRUITING NA 20 participants

Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study

Kessler Foundation

NCT06452264

RECRUITING NA 10 participants

Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS

Kessler Foundation

NCT04855825

RECRUITING NA 10 participants

Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury

State University of New York at Buffalo

NCT05762796

RECRUITING Phase 1 10 participants

Living Independence Through Functional Training

University of Florida

NCT07125378

ACTIVE NOT RECRUITING 1,892 participants

Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium

Massachusetts General Hospital

NCT06284213

ACTIVE NOT RECRUITING 600 participants

Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)

David Brunk, PA-C, MMS

NCT04033510

ACTIVE NOT RECRUITING 600 participants

BRINK (BRain In Kidney Disease) Memory Study 2.0

Anne Murray

NCT04975464

ACTIVE NOT RECRUITING NA 500 participants

Cognitive Screening Made Easy for PCPs - R33 Phase

University of Texas at Austin

NCT06162026

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Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 10
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cognitive Impairment Trial Landscape

106 indexed Cognitive Impairment studies · 46 recruiting (43%).

Phase mix: 6 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Alabama at Birmingham (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cognitive Impairment?

PlainTrial tracks 106 US clinical trials for Cognitive Impairment, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cognitive Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.