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Cognitive Impairment clinical trials
46 of 106 indexed Cognitive Impairment trials are currently recruiting.
106 US clinical trials · 46 currently recruiting
Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.
The research picture
Cognitive Impairment has 106 registered US clinical trials, 46 of them open to new participants right now, about 43% of the total.
- 46
- recruiting participants now
- 43%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of Alabama at Birmingham
Active & Recent Trials
106 total, page 1 of 3
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
5-Cog 2.0: A Pragmatic Clinical Trial
Albert Einstein College of Medicine
NCT05515224
Pacific Northwest Udall Center (PANUC) Clinical Core
University of Washington
NCT01720810
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
Weill Medical College of Cornell University
NCT06168604
Biomarker Exploration in Aging, Cognition and Neurodegeneration
University of California, Irvine
NCT03860857
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Johns Hopkins University
NCT06930560
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Stanford University
NCT03839784
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
HudsonAlpha Institute for Biotechnology
NCT07146412
Mind Your Heart-II
The Miriam Hospital
NCT05431192
Gerofit and Cognition
VA Office of Research and Development
NCT06107842
Early Age-Related Hearing Loss Investigation (EARHLI)
Columbia University
NCT06174038
Brain Health in Breast Cancer Survivors
Jonsson Comprehensive Cancer Center
NCT04297020
Cognitive Remediation Intervention to Prepare for Transition of Care
University of Alabama at Birmingham
NCT05336201
Remimazolam for Cataract Surgery
University of California, Los Angeles
NCT05980117
Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV
University of Alabama at Birmingham
NCT06013579
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
University of California, San Francisco
NCT06077292
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
University of Florida
NCT05998031
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
Mclean Hospital
NCT06191965
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Cognitive Screening Made Easy for PCPs - Administrative Supplement
University of Texas at Austin
NCT06928298
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Weill Medical College of Cornell University
NCT05081596
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
UNC Lineberger Comprehensive Cancer Center
NCT06727773
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Ohio State University
NCT06223672
Study of ALTO-101 in Patients With Schizophrenia
Alto Neuroscience
NCT06502964
Diet and Cognitive Training in Hematologic Cancer Survivors
University of Alabama at Birmingham
NCT05708716
Cancer and Mild Cognitive Impairment Dyadic Intervention
Duke University
NCT05144516
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
St. Jude Children's Research Hospital
NCT07226219
Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke
University of Pennsylvania
NCT04897334
TDCS to Improve Post-Stroke Cognitive Impairment
Johns Hopkins University
NCT05195398
Cognitive Training Intervention and Attitudes Towards Genetics
University of Alabama at Birmingham
NCT03094026
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Joseph McCollom
NCT05014399
Train Your Brain SC: Exercise for People With Mild-moderate Cognitive Impairments
University of South Carolina
NCT06799429
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
State University of New York at Buffalo
NCT05500170
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
Brigham and Women's Hospital
NCT06989619
A Study of Healthy Microbiome, Healthy Mind
Mayo Clinic
NCT06020703
Community Health Worker-Led Transition Support for Persons Living With Dementia and Caregivers
University of Texas at Austin
NCT06831318
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
Long COVID Brain Fog: Cognitive Rehabilitation Trial
University of Alabama at Birmingham
NCT06095297
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
University of Alabama at Birmingham
NCT05927974
A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
Kessler Foundation
NCT06238492
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
Kessler Foundation
NCT06452264
Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS
Kessler Foundation
NCT04855825
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
State University of New York at Buffalo
NCT05762796
Living Independence Through Functional Training
University of Florida
NCT07125378
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Massachusetts General Hospital
NCT06284213
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
David Brunk, PA-C, MMS
NCT04033510
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
Cognitive Screening Made Easy for PCPs - R33 Phase
University of Texas at Austin
NCT06162026
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 10 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cognitive Impairment Trial Landscape
106 indexed Cognitive Impairment studies · 46 recruiting (43%).
Phase mix: 6 late (III/IV) vs 12 early (I/II).
Top sponsor: University of Alabama at Birmingham (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cognitive Impairment?
PlainTrial tracks 106 US clinical trials for Cognitive Impairment, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.