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Cognitive Impairment: early-phase trial registry
46 of 106 indexed Cognitive Impairment trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #122 of 28,707 conditions by registered trial count.
106 US clinical trials · 46 currently recruiting · #122 of 28,707 conditions by registered trial count
Cognitive Impairment: 106 US clinical trials tracked, 46 recruiting.
Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.
Enrollment posture brief
Registry condition cognitive-impairment
OPEN 46 | RECR 43% | LATE 6 | EARLY 12 | RANK #122 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Healthy Volunteer (43% recruiting · 113 trials)
Cognitive Impairment lists 46 open slots (43% of 106 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cognitive Impairment on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cognitive Impairment is recruiting above its size-band peers.
46 of 106 indexed trials (43.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cognitive Impairment trials is spread across many organizations.
University of Alabama at Birmingham accounts for 7 of 106 trials (6.6%). 63 distinct sponsors appear on at least one study for this condition label.
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Typical Cognitive Impairment enrolment sits around 83 participants.
Median target enrolment is 83 among the 106 trials that report a genuine target (sentinel values excluded). 62 of those (58.5%) plan for fewer than 100 participants.
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Cognitive Impairment research is mostly interventional.
84 interventional and 22 observational studies make up this index (79.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
106 total, page 1 of 3
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
5-Cog 2.0: A Pragmatic Clinical Trial
Albert Einstein College of Medicine
NCT05515224
Pacific Northwest Udall Center (PANUC) Clinical Core
University of Washington
NCT01720810
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
Weill Medical College of Cornell University
NCT06168604
Biomarker Exploration in Aging, Cognition and Neurodegeneration
University of California, Irvine
NCT03860857
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Johns Hopkins University
NCT06930560
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Stanford University
NCT03839784
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
HudsonAlpha Institute for Biotechnology
NCT07146412
Mind Your Heart-II
The Miriam Hospital
NCT05431192
Gerofit and Cognition
VA Office of Research and Development
NCT06107842
Early Age-Related Hearing Loss Investigation (EARHLI)
Columbia University
NCT06174038
Brain Health in Breast Cancer Survivors
Jonsson Comprehensive Cancer Center
NCT04297020
Cognitive Remediation Intervention to Prepare for Transition of Care
University of Alabama at Birmingham
NCT05336201
Remimazolam for Cataract Surgery
University of California, Los Angeles
NCT05980117
Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV
University of Alabama at Birmingham
NCT06013579
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
University of California, San Francisco
NCT06077292
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
University of Florida
NCT05998031
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
Mclean Hospital
NCT06191965
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Cognitive Screening Made Easy for PCPs - Administrative Supplement
University of Texas at Austin
NCT06928298
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Weill Medical College of Cornell University
NCT05081596
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
UNC Lineberger Comprehensive Cancer Center
NCT06727773
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Ohio State University
NCT06223672
Study of ALTO-101 in Patients With Schizophrenia
Alto Neuroscience
NCT06502964
Diet and Cognitive Training in Hematologic Cancer Survivors
University of Alabama at Birmingham
NCT05708716
Cancer and Mild Cognitive Impairment Dyadic Intervention
Duke University
NCT05144516
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
St. Jude Children's Research Hospital
NCT07226219
Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke
University of Pennsylvania
NCT04897334
TDCS to Improve Post-Stroke Cognitive Impairment
Johns Hopkins University
NCT05195398
Cognitive Training Intervention and Attitudes Towards Genetics
University of Alabama at Birmingham
NCT03094026
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Joseph McCollom
NCT05014399
Train Your Brain SC: Exercise for People With Mild-moderate Cognitive Impairments
University of South Carolina
NCT06799429
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
State University of New York at Buffalo
NCT05500170
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
Brigham and Women's Hospital
NCT06989619
A Study of Healthy Microbiome, Healthy Mind
Mayo Clinic
NCT06020703
Community Health Worker-Led Transition Support for Persons Living With Dementia and Caregivers
University of Texas at Austin
NCT06831318
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
Long COVID Brain Fog: Cognitive Rehabilitation Trial
University of Alabama at Birmingham
NCT06095297
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
University of Alabama at Birmingham
NCT05927974
A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
Kessler Foundation
NCT06238492
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
Kessler Foundation
NCT06452264
Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS
Kessler Foundation
NCT04855825
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
State University of New York at Buffalo
NCT05762796
Living Independence Through Functional Training
University of Florida
NCT07125378
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Massachusetts General Hospital
NCT06284213
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
David Brunk, PA-C, MMS
NCT04033510
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
Cognitive Screening Made Easy for PCPs - R33 Phase
University of Texas at Austin
NCT06162026
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 10 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Cognitive Impairment records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cognitive Impairment trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cognitive Impairment page
106 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Cognitive Impairment trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Alabama at Birmingham sponsors the most Cognitive Impairment trials on record, review their full trial history before evaluating a specific study. See University of Alabama at Birmingham's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cognitive Impairment condition card totals 106 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.