Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Opioid Use: full-pipeline trial registry
46 of 106 indexed Opioid Use trials are currently recruiting.
Corpus placement: #122 of 28,707 conditions by registered trial count.
106 US clinical trials · 46 currently recruiting · #122 of 28,707 conditions by registered trial count
Opioid Use: 106 US clinical trials tracked, 46 recruiting.
Opioid Use is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 7 of these trials.
Enrollment posture brief
Registry condition opioid-use
OPEN 46 | RECR 43% | LATE 20 | EARLY 14 | RANK #122 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Healthy Volunteer (43% recruiting · 113 trials)
Opioid Use lists 46 open slots (43% of 106 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Use is recruiting above its size-band peers.
46 of 106 indexed trials (43.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Use trials is spread across many organizations.
Hospital for Special Surgery, New York accounts for 7 of 106 trials (6.6%). 69 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Use enrolment sits around 144 participants.
Median target enrolment is 144 among the 106 trials that report a genuine target (sentinel values excluded). 38 of those (35.8%) plan for fewer than 100 participants.
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Opioid Use research is mostly interventional.
95 interventional and 11 observational studies make up this index (89.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
106 total, page 2 of 3
Adaptations of the Brain in Chronic Pain With Opioid Exposure I
Northwestern University
NCT05203770
Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs
Drexel University
NCT05192434
Patient Utilization of Opioid Destruction Bags in the Post-op Period
University of Nebraska
NCT05875857
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Johns Hopkins University
NCT05548582
Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial
University of Missouri, Kansas City
NCT04680221
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
University of California, Davis
NCT05805423
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty
Ohio State University
NCT03498261
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
Brigham and Women's Hospital
NCT04895306
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
University of Pennsylvania
NCT04401917
PCORnet Opioid Surveillance Study
Louisiana Public Health Institute
NCT03743493
A Difference-In-Differences Analysis of New Persistent Opioid Use After Surgery
University of Michigan
NCT04805229
Increasing Implementation of Post-Operative Opioid Prescribing Guidelines
University of Pennsylvania
NCT05358522
Comparing State Payer Strategies to Prevent Unsafe Opioid Prescribing
University of Washington
NCT03932799
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Weill Medical College of Cornell University
NCT03377855
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
University of Michigan
NCT03287622
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population
University of Minnesota
NCT04601493
Safely Disposing of Surplus Prescription Opioids
Johns Hopkins University
NCT03855241
Leveraging Social Networks to Increase COVID-19 Testing Uptake
New York State Psychiatric Institute
NCT04873401
Postpartum Opioid Prescribing Patterns and Patient Utilization
Northwestern University
NCT03030742
Incorporating Acupuncture Into ERAS for Ambulatory Total Hip Replacement (THR) Surgery
Hospital for Special Surgery, New York
NCT05384860
No Opioids PrescrIptions On Discharge After Surgery
Albany Medical College
NCT04469868
Do Discounted Vouchers for Medical Cannabis Reduce Opioid Use in Adults With Pain
Vireo Health
NCT04495725
MEMO-Medical Marijuana and Opioids Study
Albert Einstein College of Medicine
NCT03268551
Opioid Use After Thyroid and Parathyroid Surgeries
The Methodist Hospital Research Institute
NCT04955444
A Prospective Assessment of Opioid Utilization Post-operatively in Sports Orthopaedic Surgeries
St. Louis University
NCT03422211
Discharge Opioid Education to Decrease Opioid Use After Cesarean
Vanderbilt University Medical Center
NCT03678870
Opioid Prescribing After Cesarean Delivery
Vanderbilt University Medical Center
NCT03168425
Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial
University of New Mexi
NCT03726476
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Hospital for Special Surgery, New York
NCT03020966
Effects of Hypnosis Therapy on Outcomes in Shoulder Replacement Therapy
Foundation for Orthopaedic Research and Education
NCT04889833
The Association Between Loneliness and Substance Use
University of Rochester
NCT04938492
Safe Options for ACL Recovery
Karen Derefinko, PhD
NCT04225468
Perioperative Pregabalin in Ureteroscopy
University of Missouri-Columbia
NCT04122196
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
HealthPartners Institute
NCT04939727
Ketamine Versus Fentanyl for Surgical Abortions
University of Washington
NCT04871425
Enhancing Prospective Thinking in Early Recovery (PARK)
Indiana University
NCT05908097
Perinatal Opioid Use
Medical University of South Carolina
NCT04049032
Lidocaine Patches After Cesarean Section
Yale University
NCT04443569
Opioid-Free Shoulder Arthroplasty
OrthoCarolina Research Institute
NCT03540030
Music Therapy in the Treatment of Perioperative Anxiety and Pain
University of Pittsburgh
NCT05263635
Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty
NYU Langone Health
NCT03457116
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
University Hospitals Cleveland Medical Center
NCT02509312
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
Ohio State University
NCT03791645
Does Altering Narcotic Prescription Methods Affect Opioid Distribution Following Select Upper Extremity Surgeries?
John Yanik
NCT03570320
Opioid Education in Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05593341
Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures
Rhode Island Hospital
NCT06299137
Managing Opioid Related Sleep Apnea With Acetazolamide
University of California, San Diego
NCT06043830
Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Wake Forest University Health Sciences
NCT04156802
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 8 |
| Phase 4 | 12 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Use page
106 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Opioid Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Hospital for Special Surgery, New York sponsors the most Opioid Use trials on record, review their full trial history before evaluating a specific study. See Hospital for Special Surgery, New York's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Use condition card totals 106 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.