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ClinicalTrials.gov 37 recruiting now official registry

Crohn's Disease clinical trials

37 of 106 indexed Crohn's Disease trials are currently recruiting.

106 US clinical trials · 37 currently recruiting

Crohn's Disease is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 46 are in Phase 3-4 (later-stage) and 36 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 13 of these trials.

The research picture

Crohn's Disease has 106 registered US clinical trials, 37 of them open to new participants right now, about 35% of the total.

37
recruiting participants now
35%
of trials open to enrollment
46
in Phase 3–4 (later-stage)
13
top sponsor: Takeda
Phase 114Phase 222Phase 341Phase 45

Active & Recent Trials

106 total, page 1 of 3

RECRUITING Phase 3 1,200 participants

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

Merck Sharp & Dohme

NCT06430801

RECRUITING Phase 3 980 participants

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

Sanofi

NCT07184931

RECRUITING Phase 3 671 participants

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

Sanofi

NCT07184944

RECRUITING NA 600 participants

Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

Weill Medical College of Cornell University

NCT03256240

RECRUITING Phase 2 540 participants

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

AbbVie

NCT06548542

RECRUITING Phase 4 400 participants

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

Takeda

NCT06581328

RECRUITING Phase 3 396 participants

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

Takeda

NCT06227910

RECRUITING Phase 2 385 participants

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

NCT06226883

RECRUITING 300 participants

Helmsley 3.0: Abbreviated MRE

Children's Hospital Medical Center, Cincinnati

NCT06533228

RECRUITING 300 participants

VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study

Alimentiv

NCT06249555

RECRUITING 300 participants

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

TScan Therapeutics

NCT06587828

RECRUITING Phase 3 290 participants

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

Eli Lilly and Company

NCT06937099

RECRUITING Phase 2 268 participants

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Takeda

NCT06233461

RECRUITING Phase 2 260 participants

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

Sanofi

NCT06637631

RECRUITING Phase 3 240 participants

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Takeda

NCT05442567

RECRUITING Phase 3 196 participants

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

Janssen Research & Development

NCT06663332

RECRUITING Phase 2 183 participants

A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)

Takeda

NCT06764615

RECRUITING NA 170 participants

Behavioral Therapy for Crohn's Disease

Icahn School of Medicine at Mount Sinai

NCT06512597

RECRUITING Phase 3 150 participants

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

Eli Lilly and Company

NCT04844606

RECRUITING Phase 2 140 participants

A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

Mirador Therapeutics

NCT07113522

RECRUITING Phase 3 120 participants

Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease

Weill Medical College of Cornell University

NCT06274554

RECRUITING Phase 3 120 participants

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT05923073

RECRUITING Phase 3 112 participants

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

Janssen-Cilag

NCT06408935

RECRUITING Phase 3 110 participants

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

AbbVie

NCT05995353

RECRUITING Phase 3 110 participants

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

AbbVie

NCT06332534

RECRUITING Phase 4 100 participants

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

Takeda

NCT06045754

RECRUITING Phase 2 99 participants

A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

Sanofi

NCT06958536

RECRUITING Phase 3 90 participants

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Eli Lilly and Company

NCT05509777

RECRUITING Phase 3 70 participants

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

Takeda

NCT06100289

RECRUITING 50 participants

Development of a Novel Endoscopic Index and Patient-reported Outcome Measure for Clinical Trials in Participants With Permanent Ileostomy

Alimentiv

NCT06670638

RECRUITING 46 participants

Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation

Icahn School of Medicine at Mount Sinai

NCT06001450

RECRUITING Early Phase 1 45 participants

68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease

Mayo Clinic

NCT07273188

RECRUITING Phase 1 39 participants

Treatment of Moderate to Severe Refractory Crohn's Disease

Tr1X

NCT06721962

RECRUITING Phase 1 35 participants

An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03167437

RECRUITING Phase 1 20 participants

Autologous Stem Cell Transplantation for Crohn's Disease

Paul Szabolcs

NCT00692939

RECRUITING Phase 1 20 participants

Beta-Hydroxybutyrate Feasibility Treating IBD

University of Texas at Austin

NCT06351124

RECRUITING NA 15 participants

A Pilot Study to Assess the Safety, Tolerability, and Efficacy of Virtual Reality for the Treatment of Abdominal Pain in Quiescent Crohn's Disease

Mayo Clinic

NCT06647615

ACTIVE NOT RECRUITING 15,000 participants

A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Target PharmaSolutions

NCT03251118

ACTIVE NOT RECRUITING 4,970 participants

A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease

Janssen Biotech

NCT00606346

ACTIVE NOT RECRUITING 1,446 participants

A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)

AbbVie

NCT02130362

ACTIVE NOT RECRUITING Phase 2 1,409 participants

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT03466411

ACTIVE NOT RECRUITING Phase 3 1,336 participants

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

AbbVie

NCT03105102

ACTIVE NOT RECRUITING Phase 3 996 participants

A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

Eli Lilly and Company

NCT04232553

ACTIVE NOT RECRUITING 925 participants

OTIS Cimzia Pregnancy Registry

University of California, San Diego

NCT01797224

ACTIVE NOT RECRUITING 750 participants

A Study of Surgical Interventions in Fistulizing Conditions

Takeda

NCT04940611

ACTIVE NOT RECRUITING Phase 3 747 participants

A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433

AbbVie

NCT03345823

ACTIVE NOT RECRUITING Phase 2 703 participants

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

Janssen Research & Development

NCT05242471

ACTIVE NOT RECRUITING Phase 3 289 participants

A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.

AbbVie

NCT06063967

ACTIVE NOT RECRUITING Phase 4 200 participants

A Study of CDPATH™ to Help Manage and Treat Crohn's Disease

Takeda

NCT04809363

ACTIVE NOT RECRUITING Phase 2 60 participants

Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP-II)

Avobis Bio

NCT04847739

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Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 22
Phase 3 41
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Crohn's Disease Trial Landscape

106 indexed Crohn's Disease studies · 37 recruiting (35%).

Phase mix: 46 late (III/IV) vs 36 early (I/II).

Top sponsor: Takeda (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Crohn's Disease?

PlainTrial tracks 106 US clinical trials for Crohn's Disease, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Crohn's Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.