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Crohn's Disease clinical trials
37 of 106 indexed Crohn's Disease trials are currently recruiting.
106 US clinical trials · 37 currently recruiting
Crohn's Disease is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 46 are in Phase 3-4 (later-stage) and 36 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 13 of these trials.
The research picture
Crohn's Disease has 106 registered US clinical trials, 37 of them open to new participants right now, about 35% of the total.
- 37
- recruiting participants now
- 35%
- of trials open to enrollment
- 46
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Takeda
Active & Recent Trials
106 total, page 1 of 3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Merck Sharp & Dohme
NCT06430801
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
Sanofi
NCT07184931
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
Sanofi
NCT07184944
Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
Weill Medical College of Cornell University
NCT03256240
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
AbbVie
NCT06548542
A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting
Takeda
NCT06581328
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
Takeda
NCT06227910
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
NCT06226883
Helmsley 3.0: Abbreviated MRE
Children's Hospital Medical Center, Cincinnati
NCT06533228
VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study
Alimentiv
NCT06249555
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
TScan Therapeutics
NCT06587828
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
Eli Lilly and Company
NCT06937099
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Takeda
NCT06233461
A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.
Sanofi
NCT06637631
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Takeda
NCT05442567
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Janssen Research & Development
NCT06663332
A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Takeda
NCT06764615
Behavioral Therapy for Crohn's Disease
Icahn School of Medicine at Mount Sinai
NCT06512597
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Eli Lilly and Company
NCT04844606
A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease
Mirador Therapeutics
NCT07113522
Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease
Weill Medical College of Cornell University
NCT06274554
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
Janssen Research & Development
NCT05923073
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
Janssen-Cilag
NCT06408935
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
AbbVie
NCT05995353
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
AbbVie
NCT06332534
A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease
Takeda
NCT06045754
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
Sanofi
NCT06958536
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Eli Lilly and Company
NCT05509777
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
Takeda
NCT06100289
Development of a Novel Endoscopic Index and Patient-reported Outcome Measure for Clinical Trials in Participants With Permanent Ileostomy
Alimentiv
NCT06670638
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
Icahn School of Medicine at Mount Sinai
NCT06001450
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
Mayo Clinic
NCT07273188
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X
NCT06721962
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03167437
Autologous Stem Cell Transplantation for Crohn's Disease
Paul Szabolcs
NCT00692939
Beta-Hydroxybutyrate Feasibility Treating IBD
University of Texas at Austin
NCT06351124
A Pilot Study to Assess the Safety, Tolerability, and Efficacy of Virtual Reality for the Treatment of Abdominal Pain in Quiescent Crohn's Disease
Mayo Clinic
NCT06647615
A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
Target PharmaSolutions
NCT03251118
A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
Janssen Biotech
NCT00606346
A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)
AbbVie
NCT02130362
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
Janssen Research & Development
NCT03466411
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
AbbVie
NCT03105102
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
Eli Lilly and Company
NCT04232553
OTIS Cimzia Pregnancy Registry
University of California, San Diego
NCT01797224
A Study of Surgical Interventions in Fistulizing Conditions
Takeda
NCT04940611
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
AbbVie
NCT03345823
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
Janssen Research & Development
NCT05242471
A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.
AbbVie
NCT06063967
A Study of CDPATH™ to Help Manage and Treat Crohn's Disease
Takeda
NCT04809363
Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP-II)
Avobis Bio
NCT04847739
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 14 |
| Phase 2 | 22 |
| Phase 3 | 41 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Crohn's Disease Trial Landscape
106 indexed Crohn's Disease studies · 37 recruiting (35%).
Phase mix: 46 late (III/IV) vs 36 early (I/II).
Top sponsor: Takeda (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Crohn's Disease?
PlainTrial tracks 106 US clinical trials for Crohn's Disease, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Crohn's Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.