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NCT04927143 · ClinicalTrials.gov registry record · NA
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
A NA study of Opioid Use Disorder and Opioid Use, sponsored by Wake Forest University Health Sciences.
- Recruiting
- Registry status
- NA
- Development phase
- 600
- Enrollment target
- 2
- Study locations
NCT04927143: Recruiting NA study of Opioid Use Disorder and Opioid Use, sponsored by Wake Forest University Health Sciences.
NCT04927143 is a NA study of Opioid Use Disorder and Opioid Use that is actively recruiting participants, run by Wake Forest University Health Sciences. The registered enrollment target is 600 participants, below the 4,654-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (87% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04927143, a NA study of Opioid Use Disorder and Opioid Use, is actively recruiting participants, sponsored by Wake Forest University Health Sciences.
- RECRUITING
- Registry status
- NA
- Development phase
- 600 participants
- Enrollment target
- 2
- Study locations
Study Summary
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore, it is not well understood how to design optimal incentives to treat opioid abuse. This project will conduct a randomized evaluation of two types of dynamically adjusting incentive schedules for people with opioid use disorders or cocaine use disorders: "escalating" schedules where incentive amounts increase with success to increase incentive power, and "de-escalating" schedules where incentive amounts decrease with success to improve incentive targeting. Both schemes are implemented with a novel "turnkey" mobile application, making them uniquely low-cost, low-hassle, and scalable. Effects will be measured on abstinence outcomes, including longest duration of abstinence and the percentage of negative drug tests. In combination with survey data, variation from the experiment will shed light on the barriers to abstinence more broadly and inform the understanding of optimal incentive design.
Primary Outcome
Percent of tests negative for non-medical opioids, cocaine, or stimulant
Conditions Studied
Interventions
- BEHAVIORAL App-Based Contingency Management
- BEHAVIORAL Sham Control
Study Locations (2)
Wisconsin
- Rogers Behavioral Health - Oconomowoc
- Advocate Aurora Behavioral Health Services - Wauwatosa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2021-09-15 |
| Est. Completion | 2026-09 |
| Phase | NA |
What NCT04927143 shows while recruiting
NCT04927143 is an interventional study that assigns participants to a tested intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, below the 4,654-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (87% lower).
The record links to 7 conditions, with Opioid Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which App-Based Contingency Management is the first listed.
NCT04927143 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT04927143 about?
NCT04927143 is a clinical study titled "Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives". Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contin...
What is the current status of trial NCT04927143?
This trial is currently recruiting. It is a NA study. The enrollment target is 600 participants. The study started on 2021-09-15. Estimated completion is 2026-09.
What conditions does trial NCT04927143 study?
This clinical trial studies the following conditions: Opioid Use Disorder, Opioid Use, Substance Use, Cocaine Use Disorder, Methamphetamine-dependence.
What interventions are being tested in trial NCT04927143?
The interventions under investigation include: App-Based Contingency Management (BEHAVIORAL), Sham Control (BEHAVIORAL).
Who is sponsoring clinical trial NCT04927143?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04927143 being conducted?
This trial has 2 study locations across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04927143's enrollment target sits among peer trials
600 27th of 257 higher than 228 of 257 other Opioid Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Opioid Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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