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Obsessive - Compulsive Disorder clinical trials
30 of 86 indexed Obsessive - Compulsive Disorder trials are currently recruiting.
86 US clinical trials · 30 currently recruiting
Obsessive - Compulsive Disorder is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Baylor College of Medicine, running 7 of these trials.
The research picture
Obsessive - Compulsive Disorder has 86 registered US clinical trials, 30 of them open to new participants right now, about 35% of the total.
- 30
- recruiting participants now
- 35%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Baylor College of Medicine
Active & Recent Trials
86 total, page 1 of 2
Retrospective Analyses of TrakStar Database
Neuronetics
NCT06917339
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
Developing Brain, Impulsivity and Compulsivity
National Institute of Mental Health (NIMH)
NCT04631042
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
University of Texas at Austin
NCT05467683
Discovering Factors in the Clinical Study Journey of Patients With OCD
Power Life Sciences
NCT05881356
Mechanisms of Exposure Therapy for OCD
Mclean Hospital
NCT06173752
CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD
Baylor College of Medicine
NCT05609916
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Brigham and Women's Hospital
NCT06376734
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Stanford University
NCT05940324
Neural Mechanisms of Response Inhibition Training for OCRD
University of Wisconsin, Milwaukee
NCT05377125
Interpretation Bias as a Mechanism of Treatment Response in OCD
Mclean Hospital
NCT05224414
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
Yale University
NCT04131829
A Multicenter Pediatric Deep Brain Stimulation Registry
Boston Children's Hospital
NCT06585618
Precision Analytic Research Methods in OCD
Icahn School of Medicine at Mount Sinai
NCT07011901
TMS + Exposure Therapy for Pediatric OCD
Bradley Hospital
NCT05931913
Study of Dextromethorphan in OCD and Related Disorders
Stanford University
NCT04899687
Individually Targeted Neuromodulation for Contamination-based OCD
Mclean Hospital
NCT05048251
Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Adam Frank
NCT07146438
Efficacy of Nitrous Oxide in OCD: Pilot Study
Stanford University
NCT03826693
Pilot Study of RR-HNK in OCD
Carolyn Rodriguez
NCT06575075
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)
Carolyn Rodriguez
NCT05783817
Using Personalized Assessments in the Treatment of Childhood OCD
Johns Hopkins University
NCT06407648
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
Francisco A Moreno
NCT07347405
Effects of Psilocybin in Obsessive Compulsive Disorder
Johns Hopkins University
NCT05546658
Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation
University of California, San Francisco
NCT07065669
Caloric Vestibular Stimulation for Modulation of Insight in Obsessive-Compulsive Spectrum Disorders
Stanford University
NCT03918577
Cortical Stimulation to Treat Obsessive Compulsive Disorder
Andrew Moses Lee, MD, PhD
NCT04958096
Personalized DBS for OCD Guided by Stereoencephalography Mapping
Andrew Moses Lee, MD, PhD
NCT06347978
SEEG-Guided DBS for OCD
Casey H. Halpern, M.D.
NCT05623306
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
Massachusetts General Hospital
NCT01075672
Individualized Neuroimaging Biomarkers for Predicting rTMS Response in OCD
Stanford University
NCT05829681
Understanding How Ketamine Brings About Rapid Improvement in OCD
Stanford University
NCT02624596
A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
University of Chicago
NCT05624528
Effects of Repeated Psilocybin Dosing in OCD
Yale University
NCT05370911
Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)
Baylor College of Medicine
NCT03459456
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
Butler Hospital
NCT00640133
Imaging-Guided Low Intensity Focused Ultrasound (LIFU)
Baylor College of Medicine
NCT05467085
Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)
Baylor College of Medicine
NCT05915741
Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder
Baylor College of Medicine
NCT04806516
Development of Adaptive Deep Brain Stimulation for OCD
Baylor College of Medicine
NCT04281134
Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)
Baylor College of Medicine
NCT03457675
Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Massachusetts General Hospital
NCT03184454
Clinical Outcomes From NOCD Treatment of Obsessive-Compulsive Disorder Using Exposure and Response Prevention
NOCD
NCT04701372
Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder
Biohaven Pharmaceuticals
NCT04693351
Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment
Mclean Hospital
NCT02305537
Physiological Brain Atlas Development
Ohio State University
NCT01210534
Predicting Treatment Response in Patients With OCD
University of Sao Paulo
NCT03993535
Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
Vanderbilt University Medical Center
NCT04335175
Psychotherapy for Anxiety in Children With Autism Spectrum Disorder
University of South Florida
NCT02028247
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 13 |
| Phase 3 | 6 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Obsessive - Compulsive Disorder Trial Landscape
86 indexed Obsessive - Compulsive Disorder studies · 30 recruiting (35%).
Phase mix: 10 late (III/IV) vs 19 early (I/II).
Top sponsor: Baylor College of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Obsessive - Compulsive Disorder?
PlainTrial tracks 86 US clinical trials for Obsessive - Compulsive Disorder, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Obsessive - Compulsive Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.