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RECRUITING NA

Neural Mechanisms of Response Inhibition Training for OCRD

NCT05377125 · View on ClinicalTrials.gov ↗

Study Summary

The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.

Interventions

  • BEHAVIORAL Computerized cognitive training
  • BEHAVIORAL Computerized placebo training

Study Locations (1)

Wisconsin

  • UWM Anxiety Disorders Laboratory — Milwaukee

Trial Details

FieldValue
Enrollment Target 118 participants
Start Date 2022-12-22
Est. Completion 2027-08
Phase NA

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05377125

The ClinicalTrials.gov registry entry for NCT05377125 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 118 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Wisconsin, Milwaukee, which has 8 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Obsessive-Compulsive Disorder appearing as the primary indexed condition, and to 2 interventions — of which Computerized cognitive training is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05377125 reports 1 study location spanning 1 distinct geographic area — top geographies include Wisconsin. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05377125 about?

NCT05377125 is a clinical study titled "Neural Mechanisms of Response Inhibition Training for OCRD". The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. Th...

What is the current status of trial NCT05377125?

This trial is currently recruiting. It is a NA study. The enrollment target is 118 participants. The study started on 2022-12-22. Estimated completion is 2027-08.

What conditions does trial NCT05377125 study?

This clinical trial studies the following conditions: Obsessive-Compulsive Disorder, Skin-Picking, Tricholemmoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05377125?

The interventions under investigation include: Computerized cognitive training (BEHAVIORAL), Computerized placebo training (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05377125?

This trial is sponsored by University of Wisconsin, Milwaukee, which has 8 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05377125 being conducted?

This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial