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NCT05377125 · ClinicalTrials.gov registry record · NA
Neural Mechanisms of Response Inhibition Training for OCRD
A NA study of Obsessive - Compulsive Disorder and Skin-Picking, sponsored by University of Wisconsin, Milwaukee.
- Recruiting
- Registry status
- NA
- Development phase
- 118
- Enrollment target
- 1
- Study location
NCT05377125: Recruiting NA study of Obsessive - Compulsive Disorder and Skin-Picking, sponsored by University of Wisconsin, Milwaukee.
NCT05377125 is a NA study of Obsessive - Compulsive Disorder and Skin-Picking that is actively recruiting participants, run by University of Wisconsin, Milwaukee. The registered enrollment target is 118 participants, below the 2,063-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05377125, a NA study of Obsessive - Compulsive Disorder and Skin-Picking, is actively recruiting participants, sponsored by University of Wisconsin, Milwaukee.
- RECRUITING
- Registry status
- NA
- Development phase
- 118 participants
- Enrollment target
- 1
- Study location
Study Summary
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.
Primary Outcome
Depending on participant's primary diagnostic condition, Yale-Brown Obsessive Compulsive Scale (YBOCS) will be used as the primary outcome measure for assessing the change in OCD symptoms over time. The total score ranges between 0 and 40 with higher scores indicating worse outcomes (= more severe symptoms).
Conditions Studied
Interventions
- BEHAVIORAL Computerized cognitive training
- BEHAVIORAL Computerized placebo training
Study Locations (1)
Wisconsin
- UWM Anxiety Disorders Laboratory - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2022-12-22 |
| Est. Completion | 2027-08 |
| Phase | NA |
What NCT05377125 shows while recruiting
NCT05377125 is an interventional study that assigns participants to a tested intervention. The registered 118 participants enrollment target is mid-sized for trials with a published cap, below the 2,063-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Obsessive - Compulsive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Computerized cognitive training is the first listed.
NCT05377125 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05377125 about?
NCT05377125 is a clinical study titled "Neural Mechanisms of Response Inhibition Training for OCRD". The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. Th...
What is the current status of trial NCT05377125?
This trial is currently recruiting. It is a NA study. The enrollment target is 118 participants. The study started on 2022-12-22. Estimated completion is 2027-08.
What conditions does trial NCT05377125 study?
This clinical trial studies the following conditions: Obsessive - Compulsive Disorder, Skin-Picking, Tricholemmoma.
What interventions are being tested in trial NCT05377125?
The interventions under investigation include: Computerized cognitive training (BEHAVIORAL), Computerized placebo training (BEHAVIORAL).
Who is sponsoring clinical trial NCT05377125?
This trial is sponsored by University of Wisconsin, Milwaukee, which has 21 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05377125 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05377125's enrollment target sits among peer trials
118 28th of 84 higher than 57 of 84 other Obsessive - Compulsive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obsessive - Compulsive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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