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NCT06173752 · ClinicalTrials.gov registry record · NA
Mechanisms of Exposure Therapy for OCD
A NA study of Obsessive - Compulsive Disorder, sponsored by Mclean Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 400
- Enrollment target
- 2
- Study locations
NCT06173752: Recruiting NA study of Obsessive - Compulsive Disorder, sponsored by Mclean Hospital.
NCT06173752 is a NA study of Obsessive - Compulsive Disorder that is actively recruiting participants, run by Mclean Hospital. The registered enrollment target is 400 participants, below the 2,060-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (81% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06173752, a NA study of Obsessive - Compulsive Disorder, is actively recruiting participants, sponsored by Mclean Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 400 participants
- Enrollment target
- 2
- Study locations
Study Summary
Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients do not recover because the mechanisms underlying successful response are poorly understood, leading to significant variability in how clinicians conduct exposure therapy. The main purpose of this study is to determine which target mechanisms are most critical to engage in real-world exposure sessions to produce good treatment outcomes. Adult participants (N = 400) with Obsessive Compulsive Disorder (OCD) receiving exposure therapy from two sites (McLean Hospital, San Diego State University) across the continuum of care (outpatient, partial hospital, residential) will complete baseline clinical and demographic measures as well as weekly symptom reports. The project will measure exposure mechanisms across three levels of analysis (self-report, observer-rated behavior, physiology) during each exposure session. Mechanisms assessed will include a broad range of variables based on both habituation and inhibitory learning models of exposure. Self-report and observer-rated mechanisms will be measured with the Exposure Feedback Form, created and piloted by the study team. Physiological mechanisms will include skin conductance response, heart rate, and heart rate variability measured with a wristwatch. The current study will determine (1) which exposure mechanisms lead to favorable clinical outcomes, and (2) what makes a good exposure for whom. Results of this study have the potential to improve personalized care for the many patients who do not remit following exposure therapy for OCD.
Primary Outcome
The YBOCS is a 10 self-report measure of OCD severity.
Conditions Studied
Interventions
- BEHAVIORAL Exposure therapy
Study Locations (2)
California
- Center for Understanding and Treating Anxiety - San Diego
Massachusetts
- McLean OCDI - Belmont
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2024-10-16 |
| Est. Completion | 2029-04 |
| Phase | NA |
What NCT06173752 shows while recruiting
NCT06173752 is an interventional study that assigns participants to a tested intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 2,060-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Obsessive - Compulsive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Exposure therapy is the first listed.
NCT06173752 reports a single indexed study location in California, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06173752 about?
NCT06173752 is a clinical study titled "Mechanisms of Exposure Therapy for OCD". Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients do not recover because the mechanisms underlying successful response are poorly understood, leading to significant variability in how clinicians conduct exposure therapy. The main ...
What is the current status of trial NCT06173752?
This trial is currently recruiting. It is a NA study. The enrollment target is 400 participants. The study started on 2024-10-16. Estimated completion is 2029-04.
What conditions does trial NCT06173752 study?
This clinical trial studies the following conditions: Obsessive - Compulsive Disorder.
What interventions are being tested in trial NCT06173752?
The interventions under investigation include: Exposure therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT06173752?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06173752 being conducted?
This trial has 2 study locations across California, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obsessive - Compulsive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06173752's enrollment target sits among peer trials
400 11th of 84 higher than 74 of 84 other Obsessive - Compulsive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obsessive - Compulsive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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