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NCT05915741 · ClinicalTrials.gov registry record
Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)
A clinical trial of Obsessive - Compulsive Disorder, sponsored by Baylor College of Medicine.
- Active
- Registry status
- 8
- Enrollment target
- 1
- Study location
NCT05915741 is a study of Obsessive - Compulsive Disorder that is active but no longer recruiting, run by Baylor College of Medicine. The registered enrollment target is 8 participants, below the 2,065-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05915741, a study of Obsessive - Compulsive Disorder, is active but no longer recruiting, sponsored by Baylor College of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
Obsessive-compulsive disorder effects approximately 2-3% of the population. The only established first-line treatments for OCD are cognitive-behavioral therapy (CBT) with exposure/response prevention and serotonin reuptake inhibitor medications (SRIs). Approximately 30-40% of patients fail to respond to either modality and few patients experience complete symptom resolution. Up to 25% of patients have difficulty tolerating CBT, and the risk of relapse after therapies remains significant. Symptoms of OCD include unwanted, distressing thoughts and rituals such as excessive washing of hands or other body parts, rechecking things such as locks or switches because of obsessional doubt, and avoidance of anxiety-provoking situations. In some cases, compulsions can consume several hours per day and in the most extreme cases can involve most of the patient's waking hours (e.g. washing hands hundreds of times per day, 18-hour showers). Medical complications may result from repeated washing or other repetitive behaviors. Significant social and occupational impairment can result from this disorder and some patients are housebound or even bed-ridden. Effective evidence-based treatments include behavior therapy and certain medications. Despite these therapies, a significant number of patients are treatment resistant and suffer persistent, debilitating symptoms. In severe cases, neurosurgical intervention is sometimes performed to alleviate symptoms. A common surgical option is deep brain stimulation (DBS), a procedure that involves placing two electrodes in a specific region in the brain and connecting them to a pacemaker-like device implanted under the skin in the upper chest. The clinician adjusts the stimulation parameters on the device to find the settings that best relieve symptoms. One of the challenges of treating a psychiatric disorder is the absence of reliable and valid biomarkers for diagnosing and objectively monitoring treatment outcomes. There is also problem of h
Conditions Studied
Study Locations (1)
Texas
- Baylor College of Medicine - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2021-05-20 |
| Est. Completion | 2026-06-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05915741
The ClinicalTrials.gov registry entry for NCT05915741 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,065-participant average among 84 other Obsessive - Compulsive Disorder trials with a reported enrollment target (100% lower). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Obsessive - Compulsive Disorder appearing as the primary indexed condition, and to 0 interventions.
NCT05915741 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT05915741 about?
NCT05915741 is a clinical study titled "Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)". Obsessive-compulsive disorder effects approximately 2-3% of the population. The only established first-line treatments for OCD are cognitive-behavioral therapy (CBT) with exposure/response prevention and serotonin reuptake inhibitor medications (SRIs). Approximately 30-40% of patients fail to respon...
What is the current status of trial NCT05915741?
This trial is currently active not recruiting. The enrollment target is 8 participants. The study started on 2021-05-20. Estimated completion is 2026-06-01.
What conditions does trial NCT05915741 study?
This clinical trial studies the following conditions: Obsessive - Compulsive Disorder.
Who is sponsoring clinical trial NCT05915741?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05915741 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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