Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

COPD

Open-data reference.

81 US clinical trials · 26 currently recruiting

Active & Recent Trials

RECRUITING NA 3,000 participants

Home Hospital for Suddenly Ill Adults

Brigham and Women's Hospital

NCT03524222

RECRUITING 3,000 participants

Interprofessional Pharmacogenomics (IPGx) Registry and Repository

Texas A&M University

NCT06726590

RECRUITING NA 800 participants

Acoustic Waveform Respiratory Evaluation

Indiana University

NCT06512064

RECRUITING NA 750 participants

Supporting Evidence-based Responses to Emotional Needs in Emphysema

University of Pennsylvania

NCT06600126

RECRUITING NA 668 participants

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

VA Office of Research and Development

NCT04179981

RECRUITING NA 642 participants

myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home

Temple University

NCT05204888

RECRUITING NA 448 participants

COPD Resources, Education, and Activity Designed for You Study

Rush University Medical Center

NCT07125053

RECRUITING 420 participants

Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT06974981

RECRUITING NA 290 participants

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

Philip Morris Products S.A.

NCT07108166

RECRUITING Phase 1 260 participants

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Mario Castro, MD, MPH

NCT04624490

RECRUITING NA 250 participants

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Apreo Health

NCT06891755

RECRUITING NA 200 participants

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

Nuvaira

NCT07051707

RECRUITING Phase 2 171 participants

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

Uniquity One (UNI)

NCT06496620

RECRUITING NA 136 participants

The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain

VA Office of Research and Development

NCT05701982

RECRUITING 100 participants

Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV

University of Pittsburgh

NCT05502653

RECRUITING NA 80 participants

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

The Cleveland Clinic

NCT07059637

RECRUITING NA 70 participants

Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital

Fisher and Paykel Healthcare

NCT07222410

RECRUITING Phase 2 56 participants

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

Verona Pharma

NCT05270525

RECRUITING NA 40 participants

The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity

VA Office of Research and Development

NCT04953806

RECRUITING Phase 4 40 participants

The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)

University of California, San Francis

NCT06152653

RECRUITING NA 36 participants

Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise

University of Colorado, Denver

NCT05896579

RECRUITING Phase 2 30 participants

Pulmonary Hypertension SOLAR

Bastiaan Driehuys

NCT04778046

RECRUITING Phase 4 30 participants

Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

University of Alabama at Birmingham

NCT07135427

RECRUITING NA 30 participants

Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD

University of Miami

NCT06578156

RECRUITING NA 28 participants

The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA

VA Office of Research and Development

NCT05254431

RECRUITING NA 24 participants

The Reducing REVISITS Study: A Cluster RCT

University of Chicago

NCT05568043

ACTIVE NOT RECRUITING NA 25,871 participants

LungVITamin D and OmegA-3 Trial (lungVITAL)

Brigham and Women's Hospital

NCT01728571

ACTIVE NOT RECRUITING 2,981 participants

Study of COPD Subgroups and Biomarkers

University of North Carolina, Chapel Hill

NCT01969344

ACTIVE NOT RECRUITING NA 914 participants

A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)

Vanderbilt University Medical Center

NCT03927820

ACTIVE NOT RECRUITING 500 participants

Impairments That Affect Correct Inhaler Use in COPD

COPD Foundation

NCT06135324

ACTIVE NOT RECRUITING NA 464 participants

Evaluation of the Safety and Efficacy of TLD in Patients with COPD

Nuvaira

NCT03639051

ACTIVE NOT RECRUITING 300 participants

Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients With Chronic Obstructive Pulmonary Disease

NuvoAir Medical PC

NCT05955482

ACTIVE NOT RECRUITING 200 participants

Michigan Early Disease Progression Cohort

University of Michigan

NCT04968249

ACTIVE NOT RECRUITING 60 participants

High Resolution Micro OCT Imaging

University of Alabama at Birmingham

NCT03256773

COMPLETED 135,856 participants

Long-term Observational Study of the Safety of Roflumilast

AstraZeneca

NCT03381573

COMPLETED 12,255 participants

Observational Study of Obstructive Lung Disease (NOVELTY)

AstraZeneca

NCT02760329

COMPLETED 5,451 participants

Epidemiology of Venous Thromboembolism

Brigham and Women's Hospital

NCT00456196

COMPLETED Phase 4 3,635 participants

Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.

AstraZeneca

NCT01966107

COMPLETED Phase 3 1,100 participants

OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)

AstraZeneca

NCT00076089

COMPLETED Phase 3 345 participants

A Trial to Evaluate the Efficacy and Safety of Formoterol Fumarate in the Treatment of Patients With COPD

Dey

NCT00215436

COMPLETED Phase 3 335 participants

Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Xiromed

NCT05986591

COMPLETED 330 participants

HIV-related Accelerated Aging of the Airway Epithelium

Weill Medical College of Cornell University

NCT01974219

COMPLETED NA 292 participants

Impact of a Peer Support Program Amongst COPD Patients and Their Caregivers

Johns Hopkins University

NCT02891200

COMPLETED NA 277 participants

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

Olympus Corporation of the Americas

NCT00475007

COMPLETED 207 participants

Autologous Stem Cell Treatment for Chronic Lung Disease Study

Lung Institute

NCT03044431

COMPLETED Phase 1 171 participants

Imaging Regional Lung Defect Severity

Hal C Charles

NCT01640288

COMPLETED NA 140 participants

A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD

VA Office of Research and Development

NCT02632552

COMPLETED 117 participants

Alpha-1 Carrier Genomics Study

Medical University of South Carolina

NCT02810327

COMPLETED 100 participants

Healthy At Home Pilot

University of Massachusetts, Worcester

NCT06000696

COMPLETED Phase 4 89 participants

Effect of Nebulized Bronchodilators on Heart Rate

Fahim Khorfan, MD

NCT01151579

COMPLETED 88 participants

A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).

Centocor

NCT00380796

COMPLETED 72 participants

Functional Proteomics of Alveolar Macrophages

Ohio State University

NCT00806091

COMPLETED NA 71 participants

At Home Spirometry and Video Module Education for COPD Patients

University of Chicago

NCT03834350

COMPLETED Phase 2 64 participants

A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02109172

COMPLETED Phase 2 58 participants

MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects

Xemed

NCT01833390

COMPLETED NA 52 participants

Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)

Johns Hopkins University

NCT01764165

COMPLETED Phase 4 50 participants

Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Johns Hopkins University

NCT00181207

COMPLETED NA 50 participants

Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT

University of Alabama at Birmingham

NCT05040386

COMPLETED Phase 1 44 participants

Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen

Hal C Charles

NCT01710449

COMPLETED 42 participants

Integrative-omics of the Disordered COPD Small Airway Epithelium

Weill Medical College of Cornell University

NCT02183818

COMPLETED NA 42 participants

Vector Engineering Clinical

Philips Clinical & Medical Affairs Global

NCT04725500

COMPLETED NA 42 participants

Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD

Columbia University

NCT04786184

COMPLETED NA 40 participants

Randomized Controlled Eight-Week Study of the Safety and Efficacy of the Lung Flute

Medical Acoustics

NCT00560105

COMPLETED NA 32 participants

Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation

Yale University

NCT01799330

COMPLETED NA 31 participants

A Phase I Study of iPS Cell Generation From Patients With COPD

Mayo Clinic

NCT01860898

COMPLETED Phase 4 30 participants

Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD

Pulmonary Research Institute of Southeast Michigan

NCT04606394

COMPLETED Phase 1 30 participants

Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)

VA Loma Linda Health Care System

NCT00655993

COMPLETED NA 30 participants

Evaluation of Muscle Activation Efficiency in Challenging Subjects

Niveus Medical

NCT01811446

COMPLETED NA 27 participants

A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)

University of Alabama at Birmingham

NCT01572948

COMPLETED 21 participants

The Trajectory of Physical Activity Following Pulmonary Rehabilitation

Trinity Health Of New England

NCT02399254

COMPLETED NA 20 participants

Interleukin-5 Receptor Expression in COPD

University of Virginia

NCT03984799

COMPLETED Phase 4 20 participants

Effect of Brovana and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)

Trinity Health Of New England

NCT00773786

COMPLETED Phase 1 20 participants

Mindfulness Based Stress Reduction in COPD

Mayo Clinic

NCT01058499

COMPLETED Phase 1 17 participants

Real-Time Support for Exercise Persistence in COPD

University of Washington

NCT00373932

COMPLETED Phase 4 15 participants

Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients

Gary L. Pierce

NCT03611699

COMPLETED NA 12 participants

Innovative Pulmonary Rehabilitation Telehealth Program for Improving COPD Patient Outcomes

University of Kansas Medical Center

NCT03489642

COMPLETED NA 12 participants

Use of Dexmedetomidine for Sedation During Flexible Bronchoscopy in Patients With COPD: A Descriptive Study

The Cooper Health System

NCT00401206

COMPLETED NA 11 participants

Device-guided Breathing for Shortness of Breath in COPD

Mayo Clinic

NCT01286181

COMPLETED 9 participants

BRAIN, Symptoms, and Physical Activity in COPD

VA Office of Research and Development

NCT04291131

COMPLETED Phase 2 6 participants

Study to Assess the Safety and Tolerability of Incremental Doses of QAB149 in Adults With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD)

Novartis

NCT00129831

COMPLETED NA 6 participants

A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients

Mayo Clinic

NCT03814980

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 6
Phase 3 3
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COPD Trial Landscape

ClinicalTrials.gov lists 81 US studies indexed under COPD, and 26 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for COPD shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for COPD is led by VA Office of Research and Development with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 81 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COPD?

PlainTrial tracks 81 US clinical trials for COPD, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COPD?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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