Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
COPD: full-pipeline trial registry
28 of 86 indexed COPD trials are currently recruiting.
Corpus placement: #160 of 28,707 conditions by registered trial count.
86 US clinical trials · 28 currently recruiting · #160 of 28,707 conditions by registered trial count
COPD: 86 US clinical trials tracked, 28 recruiting.
COPD is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
Enrollment posture brief
Registry condition copd
OPEN 28 | RECR 33% | LATE 11 | EARLY 12 | RANK #160 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Recurrent Ovarian Carcinoma (33% recruiting · 40 trials)
COPD lists 28 open slots (33% of 86 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for COPD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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COPD is recruiting below its size-band peers.
28 of 86 indexed trials (32.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of COPD trials is spread across many organizations.
VA Office of Research and Development accounts for 6 of 86 trials (7%). 63 distinct sponsors appear on at least one study for this condition label.
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Typical COPD enrolment sits around 74 participants.
Median target enrolment is 74 among the 86 trials that report a genuine target (sentinel values excluded). 47 of those (54.7%) plan for fewer than 100 participants.
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COPD research is mostly interventional.
66 interventional and 20 observational studies make up this index (76.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
86 total, page 1 of 2
Home Hospital for Suddenly Ill Adults
Brigham and Women's Hospital
NCT03524222
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
Texas A&M University
NCT06726590
Acoustic Waveform Respiratory Evaluation
Indiana University
NCT06512064
Supporting Evidence-based Responses to Emotional Needs in Emphysema
University of Pennsylvania
NCT06600126
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
VA Office of Research and Development
NCT04179981
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
Temple University
NCT05204888
COPD Resources, Education, and Activity Designed for You Study
Rush University Medical Center
NCT07125053
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT06974981
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Mario Castro, MD, MPH
NCT04624490
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Apreo Health
NCT06891755
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Nuvaira
NCT07051707
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Uniquity One (UNI)
NCT06496620
Inhaler Trainer Efficacy Study
Koronis Biomedical Technologies
NCT06461403
The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain
VA Office of Research and Development
NCT05701982
Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
University of Pittsburgh
NCT05502653
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
The Cleveland Clinic
NCT07059637
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
Fisher and Paykel Healthcare
NCT07222410
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
Verona Pharma
NCT05270525
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
VA Office of Research and Development
NCT04953806
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
University of California, San Francisco
NCT06152653
Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise
University of Colorado, Denver
NCT05896579
Pulmonary Hypertension SOLAR
Bastiaan Driehuys
NCT04778046
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
University of Alabama at Birmingham
NCT07135427
Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
University of Miami
NCT06578156
Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
MGH Institute of Health Professions
NCT06304207
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
VA Office of Research and Development
NCT05254431
The Reducing REVISITS Study: A Cluster RCT
University of Chicago
NCT05568043
LungVITamin D and OmegA-3 Trial (lungVITAL)
Brigham and Women's Hospital
NCT01728571
Study of COPD Subgroups and Biomarkers
University of North Carolina, Chapel Hill
NCT01969344
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
Vanderbilt University Medical Center
NCT03927820
Impairments That Affect Correct Inhaler Use in COPD
COPD Foundation
NCT06135324
Evaluation of the Safety and Efficacy of TLD in Patients with COPD
Nuvaira
NCT03639051
Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients With Chronic Obstructive Pulmonary Disease
NuvoAir Medical PC
NCT05955482
Michigan Early Disease Progression Cohort
University of Michigan
NCT04968249
High Resolution Micro OCT Imaging
University of Alabama at Birmingham
NCT03256773
Long-term Observational Study of the Safety of Roflumilast
AstraZeneca
NCT03381573
Observational Study of Obstructive Lung Disease (NOVELTY)
AstraZeneca
NCT02760329
Epidemiology of Venous Thromboembolism
Brigham and Women's Hospital
NCT00456196
Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.
AstraZeneca
NCT01966107
OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)
AstraZeneca
NCT00076089
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
Kaiser Permanente
NCT04351880
A Trial to Evaluate the Efficacy and Safety of Formoterol Fumarate in the Treatment of Patients With COPD
Dey
NCT00215436
Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Xiromed
NCT05986591
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
Impact of a Peer Support Program Amongst COPD Patients and Their Caregivers
Johns Hopkins University
NCT02891200
Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema
Olympus Corporation of the Americas
NCT00475007
Autologous Stem Cell Treatment for Chronic Lung Disease Study
Lung Institute
NCT03044431
Imaging Regional Lung Defect Severity
Hal C Charles
NCT01640288
A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD
VA Office of Research and Development
NCT02632552
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 6 |
| Phase 3 | 3 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on COPD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on COPD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this COPD page
86 registered trials, 28 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 28 COPD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most COPD trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This COPD condition card totals 86 registered trials; most-linked intervention Placebo; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.