Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
COPD
Open-data reference.
81 US clinical trials · 26 currently recruiting
Active & Recent Trials
Home Hospital for Suddenly Ill Adults
Brigham and Women's Hospital
NCT03524222
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
Texas A&M University
NCT06726590
Acoustic Waveform Respiratory Evaluation
Indiana University
NCT06512064
Supporting Evidence-based Responses to Emotional Needs in Emphysema
University of Pennsylvania
NCT06600126
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
VA Office of Research and Development
NCT04179981
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
Temple University
NCT05204888
COPD Resources, Education, and Activity Designed for You Study
Rush University Medical Center
NCT07125053
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT06974981
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Mario Castro, MD, MPH
NCT04624490
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Apreo Health
NCT06891755
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Nuvaira
NCT07051707
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Uniquity One (UNI)
NCT06496620
The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain
VA Office of Research and Development
NCT05701982
Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
University of Pittsburgh
NCT05502653
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
The Cleveland Clinic
NCT07059637
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
Fisher and Paykel Healthcare
NCT07222410
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
Verona Pharma
NCT05270525
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
VA Office of Research and Development
NCT04953806
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
University of California, San Francis
NCT06152653
Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise
University of Colorado, Denver
NCT05896579
Pulmonary Hypertension SOLAR
Bastiaan Driehuys
NCT04778046
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
University of Alabama at Birmingham
NCT07135427
Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
University of Miami
NCT06578156
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
VA Office of Research and Development
NCT05254431
The Reducing REVISITS Study: A Cluster RCT
University of Chicago
NCT05568043
LungVITamin D and OmegA-3 Trial (lungVITAL)
Brigham and Women's Hospital
NCT01728571
Study of COPD Subgroups and Biomarkers
University of North Carolina, Chapel Hill
NCT01969344
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
Vanderbilt University Medical Center
NCT03927820
Impairments That Affect Correct Inhaler Use in COPD
COPD Foundation
NCT06135324
Evaluation of the Safety and Efficacy of TLD in Patients with COPD
Nuvaira
NCT03639051
Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients With Chronic Obstructive Pulmonary Disease
NuvoAir Medical PC
NCT05955482
Michigan Early Disease Progression Cohort
University of Michigan
NCT04968249
High Resolution Micro OCT Imaging
University of Alabama at Birmingham
NCT03256773
Long-term Observational Study of the Safety of Roflumilast
AstraZeneca
NCT03381573
Observational Study of Obstructive Lung Disease (NOVELTY)
AstraZeneca
NCT02760329
Epidemiology of Venous Thromboembolism
Brigham and Women's Hospital
NCT00456196
Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.
AstraZeneca
NCT01966107
OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)
AstraZeneca
NCT00076089
A Trial to Evaluate the Efficacy and Safety of Formoterol Fumarate in the Treatment of Patients With COPD
Dey
NCT00215436
Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Xiromed
NCT05986591
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
Impact of a Peer Support Program Amongst COPD Patients and Their Caregivers
Johns Hopkins University
NCT02891200
Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema
Olympus Corporation of the Americas
NCT00475007
Autologous Stem Cell Treatment for Chronic Lung Disease Study
Lung Institute
NCT03044431
Imaging Regional Lung Defect Severity
Hal C Charles
NCT01640288
A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD
VA Office of Research and Development
NCT02632552
Alpha-1 Carrier Genomics Study
Medical University of South Carolina
NCT02810327
Healthy At Home Pilot
University of Massachusetts, Worcester
NCT06000696
Effect of Nebulized Bronchodilators on Heart Rate
Fahim Khorfan, MD
NCT01151579
A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
Centocor
NCT00380796
Functional Proteomics of Alveolar Macrophages
Ohio State University
NCT00806091
At Home Spirometry and Video Module Education for COPD Patients
University of Chicago
NCT03834350
A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
Mylan
NCT02109172
MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
Xemed
NCT01833390
Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)
Johns Hopkins University
NCT01764165
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Johns Hopkins University
NCT00181207
Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT
University of Alabama at Birmingham
NCT05040386
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
Hal C Charles
NCT01710449
Integrative-omics of the Disordered COPD Small Airway Epithelium
Weill Medical College of Cornell University
NCT02183818
Vector Engineering Clinical
Philips Clinical & Medical Affairs Global
NCT04725500
Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD
Columbia University
NCT04786184
Randomized Controlled Eight-Week Study of the Safety and Efficacy of the Lung Flute
Medical Acoustics
NCT00560105
Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation
Yale University
NCT01799330
A Phase I Study of iPS Cell Generation From Patients With COPD
Mayo Clinic
NCT01860898
Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD
Pulmonary Research Institute of Southeast Michigan
NCT04606394
Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)
VA Loma Linda Health Care System
NCT00655993
Evaluation of Muscle Activation Efficiency in Challenging Subjects
Niveus Medical
NCT01811446
A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)
University of Alabama at Birmingham
NCT01572948
The Trajectory of Physical Activity Following Pulmonary Rehabilitation
Trinity Health Of New England
NCT02399254
Interleukin-5 Receptor Expression in COPD
University of Virginia
NCT03984799
Effect of Brovana and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)
Trinity Health Of New England
NCT00773786
Mindfulness Based Stress Reduction in COPD
Mayo Clinic
NCT01058499
Real-Time Support for Exercise Persistence in COPD
University of Washington
NCT00373932
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
Gary L. Pierce
NCT03611699
Innovative Pulmonary Rehabilitation Telehealth Program for Improving COPD Patient Outcomes
University of Kansas Medical Center
NCT03489642
Use of Dexmedetomidine for Sedation During Flexible Bronchoscopy in Patients With COPD: A Descriptive Study
The Cooper Health System
NCT00401206
Device-guided Breathing for Shortness of Breath in COPD
Mayo Clinic
NCT01286181
BRAIN, Symptoms, and Physical Activity in COPD
VA Office of Research and Development
NCT04291131
Study to Assess the Safety and Tolerability of Incremental Doses of QAB149 in Adults With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD)
Novartis
NCT00129831
A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients
Mayo Clinic
NCT03814980
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 6 |
| Phase 3 | 3 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COPD Trial Landscape
ClinicalTrials.gov lists 81 US studies indexed under COPD, and 26 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for COPD shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for COPD is led by VA Office of Research and Development with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 81 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COPD?
PlainTrial tracks 81 US clinical trials for COPD, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COPD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.