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COPD clinical trials
28 of 86 indexed COPD trials are currently recruiting.
86 US clinical trials · 28 currently recruiting
COPD is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
The research picture
COPD has 86 registered US clinical trials, 28 of them open to new participants right now, about 33% of the total.
- 28
- recruiting participants now
- 33%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 6
- top sponsor: VA Office of Research and Development
Active & Recent Trials
86 total, page 1 of 2
Home Hospital for Suddenly Ill Adults
Brigham and Women's Hospital
NCT03524222
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
Texas A&M University
NCT06726590
Acoustic Waveform Respiratory Evaluation
Indiana University
NCT06512064
Supporting Evidence-based Responses to Emotional Needs in Emphysema
University of Pennsylvania
NCT06600126
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
VA Office of Research and Development
NCT04179981
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
Temple University
NCT05204888
COPD Resources, Education, and Activity Designed for You Study
Rush University Medical Center
NCT07125053
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT06974981
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Mario Castro, MD, MPH
NCT04624490
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Apreo Health
NCT06891755
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Nuvaira
NCT07051707
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Uniquity One (UNI)
NCT06496620
Inhaler Trainer Efficacy Study
Koronis Biomedical Technologies
NCT06461403
The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain
VA Office of Research and Development
NCT05701982
Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
University of Pittsburgh
NCT05502653
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
The Cleveland Clinic
NCT07059637
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
Fisher and Paykel Healthcare
NCT07222410
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
Verona Pharma
NCT05270525
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
VA Office of Research and Development
NCT04953806
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
University of California, San Francisco
NCT06152653
Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise
University of Colorado, Denver
NCT05896579
Pulmonary Hypertension SOLAR
Bastiaan Driehuys
NCT04778046
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
University of Alabama at Birmingham
NCT07135427
Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
University of Miami
NCT06578156
Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
MGH Institute of Health Professions
NCT06304207
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
VA Office of Research and Development
NCT05254431
The Reducing REVISITS Study: A Cluster RCT
University of Chicago
NCT05568043
LungVITamin D and OmegA-3 Trial (lungVITAL)
Brigham and Women's Hospital
NCT01728571
Study of COPD Subgroups and Biomarkers
University of North Carolina, Chapel Hill
NCT01969344
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
Vanderbilt University Medical Center
NCT03927820
Impairments That Affect Correct Inhaler Use in COPD
COPD Foundation
NCT06135324
Evaluation of the Safety and Efficacy of TLD in Patients with COPD
Nuvaira
NCT03639051
Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients With Chronic Obstructive Pulmonary Disease
NuvoAir Medical PC
NCT05955482
Michigan Early Disease Progression Cohort
University of Michigan
NCT04968249
High Resolution Micro OCT Imaging
University of Alabama at Birmingham
NCT03256773
Long-term Observational Study of the Safety of Roflumilast
AstraZeneca
NCT03381573
Observational Study of Obstructive Lung Disease (NOVELTY)
AstraZeneca
NCT02760329
Epidemiology of Venous Thromboembolism
Brigham and Women's Hospital
NCT00456196
Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.
AstraZeneca
NCT01966107
OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)
AstraZeneca
NCT00076089
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
Kaiser Permanente
NCT04351880
A Trial to Evaluate the Efficacy and Safety of Formoterol Fumarate in the Treatment of Patients With COPD
Dey
NCT00215436
Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Xiromed
NCT05986591
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
Impact of a Peer Support Program Amongst COPD Patients and Their Caregivers
Johns Hopkins University
NCT02891200
Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema
Olympus Corporation of the Americas
NCT00475007
Autologous Stem Cell Treatment for Chronic Lung Disease Study
Lung Institute
NCT03044431
Imaging Regional Lung Defect Severity
Hal C Charles
NCT01640288
A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD
VA Office of Research and Development
NCT02632552
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 6 |
| Phase 3 | 3 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COPD Trial Landscape
86 indexed COPD studies · 28 recruiting (33%).
Phase mix: 11 late (III/IV) vs 12 early (I/II).
Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COPD?
PlainTrial tracks 86 US clinical trials for COPD, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COPD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.