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Heart Diseases: later-stage trial registry
26 of 86 indexed Heart Diseases trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #160 of 28,707 conditions by registered trial count.
86 US clinical trials · 26 currently recruiting · #160 of 28,707 conditions by registered trial count
Heart Diseases: 86 US clinical trials tracked, 26 recruiting.
Heart Diseases is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 7 of these trials.
Enrollment posture brief
Registry condition heart-diseases
OPEN 26 | RECR 30% | LATE 11 | EARLY 7 | RANK #160 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Smoking Cessation (30% recruiting · 189 trials)
Heart Diseases lists 26 open slots (30% of 86 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Diseases on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Diseases is recruiting below its size-band peers.
26 of 86 indexed trials (30.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Diseases trials is spread across many organizations.
National Heart, Lung, and Blood Institute (NHLBI) accounts for 7 of 86 trials (8.1%). 64 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Diseases enrolment sits around 349 participants.
Median target enrolment is 349 among the 86 trials that report a genuine target (sentinel values excluded). 16 of those (18.6%) plan for fewer than 100 participants.
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Heart Diseases splits between interventional and observational designs.
54 interventional and 32 observational studies make up this index (62.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
86 total, page 1 of 2
Personalized Responses to Dietary Composition Trial 3
Zoe Global Limited
NCT04735835
MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
Scripps Translational Science Institute
NCT03277365
Health Electronic Assessment of Risks and Trends Using Biometric Equipment and Technology
Tulane University
NCT06753045
Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study
The University of Texas Health Science Center at San Antonio
NCT05006729
Abbott Structural Heart Device Registry
Abbott Medical Devices
NCT06590467
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Weill Medical College of Cornell University
NCT04124120
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
University of Chicago
NCT01280825
Mayo AVC Registry and Biobank
Mayo Clinic
NCT03049254
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
AliveCor
NCT06271577
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Abbott Medical Devices
NCT06526195
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
BrioHealth Solutions
NCT06310031
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Fundación EPIC
NCT07286578
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Eidos Therapeutics, a BridgeBio company
NCT06563895
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
University of New Mexi
NCT04185844
The PulsePoint Study
Dr. Steven Brooks
NCT04806958
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
IPSC Repository of Pediatric Cardiovascular Disease
Mingtao Zhao
NCT05550324
South Asians and Coronary Plaque Registry
University of Texas Southwestern Medical Center
NCT05367297
Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women
Arizona State University
NCT06337708
Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health
University of Miami
NCT06587204
Lumason® Infusion vs. Bolus Administrations
Bracco Diagnostics
NCT06400004
Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department
Rush University Medical Center
NCT06769880
Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
University of California, San Francisco
NCT07087184
Transition to KPL-387 Monotherapy Dosing & Administration Study
Kiniksa Pharmaceuticals International
NCT07288216
Angiography and Electrogram Guided Bachmann Bundle Pacing
Pugazhendhi Vijayaraman
NCT07110922
PKP2-ACM Natural History Study
Rocket Pharmaceuticals
NCT06644742
Genetic Testing of CYP2C19 in Prognostic Evaluation of Long-Term Major Adverse Cardiac and Vascular Events
University of Florida
NCT06855394
Bogalusa Heart Study
Tulane University
NCT00005129
University of North Carolina Alumni Heart Study
Duke University
NCT00005398
Cardiovascular Health Study (CHS)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005133
The Jackson Heart Study of Cardiovascular Disease Among African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005485
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
University of Pennsylvania
NCT04779827
Randomization of Single vs Multiple Arterial Grafts
Weill Medical College of Cornell University
NCT03217006
The Change Club Study: Evaluation of Civic Engagement for Built Environment Change and Health Improvement
Texas A&M University
NCT05002660
Mediators of Atherosclerosis in South Asians Living in America
University of California, San Francisco
NCT01207167
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
Edwards Lifesciences
NCT03042104
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
atHeart Medical
NCT04591392
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
University of British Columbia
NCT03575910
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation
University of Rochester
NCT04922281
Intraoperative Echocardiography in Low-Risk CABG Surgery
University of Pennsylvania
NCT06154265
Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest
National Heart, Lung, and Blood Institute (NHLBI)
NCT00047411
Identifying Genes That May Increase the Risk for Heart Disease in African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00344136
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
NYU Langone Health
NCT01471522
Occluded Artery Trial (OAT)
NYU Langone Health
NCT00004562
Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease
Duke University
NCT00023595
IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
Tufts Medical Center
NCT00091507
A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)
Eli Lilly and Company
NCT00059215
Understanding the Impact of Neighborhood Type on Physical Activity in Older Adults
Stanford University
NCT00094211
Clinician Counseling and Cultural Competency to Improve Hypertension Control and Therapy Adherence
Boston Medical Center
NCT00201149
ISCHEMIA-Chronic Kidney Disease Trial
NYU Langone Health
NCT01985360
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 9 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Diseases records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Diseases trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Diseases page
86 registered trials, 26 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 26 Heart Diseases trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Heart, Lung, and Blood Institute (NHLBI) sponsors the most Heart Diseases trials on record, review their full trial history before evaluating a specific study. See National Heart, Lung, and Blood Institute (NHLBI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Diseases condition card totals 86 registered trials; most-linked intervention Medication; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.