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Heart Diseases
Open-data reference.
86 US clinical trials · 26 currently recruiting
Active & Recent Trials
Personalized Responses to Dietary Composition Trial 3
Zoe Global Limited
NCT04735835
MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
Scripps Translational Science Institute
NCT03277365
Health Electronic Assessment of Risks and Trends Using Biometric Equipment and Technology
Tulane University
NCT06753045
Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study
The University of Texas Health Science Center at San Antonio
NCT05006729
Abbott Structural Heart Device Registry
Abbott Medical Devices
NCT06590467
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Weill Medical College of Cornell University
NCT04124120
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
University of Chicago
NCT01280825
Mayo AVC Registry and Biobank
Mayo Clinic
NCT03049254
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
AliveCor
NCT06271577
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Abbott Medical Devices
NCT06526195
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
BrioHealth Solutions
NCT06310031
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Fundación EPIC
NCT07286578
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Eidos Therapeutics, a BridgeBio company
NCT06563895
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
University of New Mexi
NCT04185844
The PulsePoint Study
Dr. Steven Brooks
NCT04806958
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
IPSC Repository of Pediatric Cardiovascular Disease
Mingtao Zhao
NCT05550324
South Asians and Coronary Plaque Registry
University of Texas Southwestern Medical Center
NCT05367297
Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women
Arizona State University
NCT06337708
Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health
University of Miami
NCT06587204
Lumason® Infusion vs. Bolus Administrations
Bracco Diagnostics
NCT06400004
Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department
Rush University Medical Center
NCT06769880
Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
University of California, San Francis
NCT07087184
Transition to KPL-387 Monotherapy Dosing & Administration Study
Kiniksa Pharmaceuticals International
NCT07288216
Angiography and Electrogram Guided Bachmann Bundle Pacing
Pugazhendhi Vijayaraman
NCT07110922
PKP2-ACM Natural History Study
Rocket Pharmaceuticals
NCT06644742
Genetic Testing of CYP2C19 in Prognostic Evaluation of Long-Term Major Adverse Cardiac and Vascular Events
University of Florida
NCT06855394
Bogalusa Heart Study
Tulane University
NCT00005129
University of North Carolina Alumni Heart Study
Duke University
NCT00005398
Cardiovascular Health Study (CHS)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005133
The Jackson Heart Study of Cardiovascular Disease Among African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005485
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
University of Pennsylvania
NCT04779827
Randomization of Single vs Multiple Arterial Grafts
Weill Medical College of Cornell University
NCT03217006
The Change Club Study: Evaluation of Civic Engagement for Built Environment Change and Health Improvement
Texas A&M University
NCT05002660
Mediators of Atherosclerosis in South Asians Living in America
University of California, San Francis
NCT01207167
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
Edwards Lifesciences
NCT03042104
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
atHeart Medical
NCT04591392
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
University of British Columbia
NCT03575910
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation
University of Rochester
NCT04922281
Intraoperative Echocardiography in Low-Risk CABG Surgery
University of Pennsylvania
NCT06154265
Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest
National Heart, Lung, and Blood Institute (NHLBI)
NCT00047411
Identifying Genes That May Increase the Risk for Heart Disease in African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00344136
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
NYU Langone Health
NCT01471522
Occluded Artery Trial (OAT)
NYU Langone Health
NCT00004562
Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease
Duke University
NCT00023595
IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
Tufts Medical Center
NCT00091507
A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)
Eli Lilly and Company
NCT00059215
Understanding the Impact of Neighborhood Type on Physical Activity in Older Adults
Stanford University
NCT00094211
Clinician Counseling and Cultural Competency to Improve Hypertension Control and Therapy Adherence
Boston Medical Center
NCT00201149
ISCHEMIA-Chronic Kidney Disease Trial
NYU Langone Health
NCT01985360
CV Disease in Adolescents With Type 2 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT00114998
Heart Rate Variability and Sudden Cardiac Death
Columbia University
NCT00005235
Physician Uncertainty Reduction for Hypertension
Baylor College of Medicine
NCT00201084
Comparison of Two Methods to Diagnose Coronary Artery Disease
Johns Hopkins University
NCT00063531
Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection
University of Missouri, Kansas City
NCT02046902
HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms
Edwards Lifesciences
NCT05009589
Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal
Windber Research Institute
NCT01805492
Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
Duke University
NCT00041392
Pain Assessment, Incidence & Nature in Heart Failure
PC-HEART
NCT00444301
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
University of Washington
NCT00880178
Multidisciplinary Study of Right Ventricular Dysplasia
University of Arizona
NCT00024505
Estrogen, HDL, and Coronary Heart Disease in Women
Tufts University
NCT00083824
Effects of Resistance and Aerobic Exercise on Cardiovascular Health
Duke University
NCT00275145
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
Baylor Research Institute
NCT00224809
Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study
University of Michigan
NCT04587882
Epidemiology of Hypertensive Emergency
Columbia University
NCT00005240
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001891
Effect of Targeted Interventions to Improve Value Based Health Care for Inpatient Cardiology Patients
Vanderbilt University Medical Center
NCT03173157
Sapphire 3 CTO Study
OrbusNeich
NCT06358508
Strong People Strength Training Study
Cornell University
NCT04203563
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
University of Miami
NCT00253682
Comparison of Hematocrit Levels in Infant Heart Surgery
National Heart, Lung, and Blood Institute (NHLBI)
NCT00006183
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
University of Louisville
NCT03969836
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
Marc Sakwa, MD
NCT01681095
Transseptal Needle Versus Radiofrequency Energy for Left Atrial Access
University of California, San Francis
NCT01209260
D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management
Medtronic Cardiac Rhythm and Heart Failure
NCT00328705
Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers
National Institute on Aging (NIA)
NCT00233311
Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease
East Tennessee State University
NCT04195932
SelectSecure 3830 Lead Imaging
Medtronic Cardiac Rhythm and Heart Failure
NCT03941275
Mindfulness & Stress Management Study for Cardiac Patients
University of Minnesota
NCT02722213
Dairy Fat and Fermentation Study
Tufts University
NCT05840081
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
Loma Linda University
NCT03429920
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
Ablacon
NCT05481359
Pilot Study of Using Copeptin to Predict Response to Tolvaptan
University of North Carolina, Chapel Hill
NCT01346072
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
Katherine Vickery
NCT06025721
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
National Heart, Lung, and Blood Institute (NHLBI)
NCT00099996
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 9 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Diseases Trial Landscape
ClinicalTrials.gov lists 86 US studies indexed under Heart Diseases, and 26 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Heart Diseases shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Heart Diseases is led by National Heart, Lung, and Blood Institute (NHLBI) with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 86 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Diseases?
PlainTrial tracks 86 US clinical trials for Heart Diseases, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Diseases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.