Mclean Hospital
Trial Pipeline
Stress Dynamics and Familial Risk for Depression in Female Adolescents
NCT06816329
Pharmacologic Augmentation of TMS for Depression With D-serine
NCT06876129
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
NCT05232032
Mechanisms of Exposure Therapy for OCD
NCT06173752
Cerebellar Modulation of Cognition in Psychosis
NCT06107764
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
NCT06191965
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
NCT06221852
Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis
NCT06477406
Enhanced Coordinated Specialty Care for Early Psychosis
NCT06071858
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
NCT05837104
Following Outcomes Remotely Within Addiction Recovery Domains
NCT06001437
Role of Parent Interpretation Bias in the Transmission of Anxiety to Children
NCT05665491
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
NCT05457465
Individually Targeted Neuromodulation for Contamination-based OCD
NCT05048251
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
NCT05245903
Interpretation Bias as a Mechanism of Treatment Response in OCD
NCT05224414
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
NCT04430517
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
NCT05630963
Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents
NCT04697966
Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia
NCT05343598
Neural Correlates of Stress and Perceived Control in Adolescent Depression
NCT04788524
Early Life Stress and Depression: Molecular and Functional Imaging
NCT04713722
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
NCT04075435
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)
NCT04325529
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
NCT03484494
Online Emotional Response to Completing a Childhood Maltreatment Self-report Scale
NCT06152549
SMART Trial to Predict Anhedonia Response to Antidepressant Treatment
NCT05537584
Families With Substance Use and Psychosis: A Pilot Study
NCT04284813
Novel Cross-Species Neurophysiological Assays of Reward and Cognitive Domains
NCT02855229
Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
NCT04635748
Cognitive Bias Modification for OCD
NCT03799419
Effect of Nicotine on Brain Reward Pathways
NCT02346539
Study of Treatment for Opioid Dependence and Anxiety Disorders
NCT02252068
Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment
NCT02305537
Neural Mechanisms Underlying Nicotine and Alcohol Combinations
NCT02049268
Brain Mechanisms of Emotion and Motivation: A Mind-Body Study
NCT01850472
Longitudinal Multimodal Neuroimaging Studies in Patients With First Episode Psychosis
NCT01688765
Depression and Dopamine Transporter Function Study Using C-11 Altropane
NCT01701141
Dopamine Neurotransmission in Major Depression
NCT01659814
Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder.
NCT01148979
A Trial of SAMe for Treatment-Resistant Bipolar Depression
NCT00762268
Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device
NCT00578383
Transdermal Electroacupuncture for Opioid Detoxification
NCT00742170
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
NCT00431184
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
NCT01588561
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
NCT00125957
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 37 |
| Phase 3 | 1 |
| Phase 4 | 2 |
Therapeutic Areas
What the Pipeline for Mclean Hospital Shows
According to the ClinicalTrials.gov registry, Mclean Hospital is linked to 160 US clinical trials across every stage of research activity. Of those, 137 studies are currently recruiting — about 86% of the sponsor's indexed portfolio — and 21 are already marked complete, representing roughly 13% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Mclean Hospital reports 3 late-stage studies (Phase 3 and Phase 4 combined) and 42 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Mclean Hospital is Major Depressive Disorder with 9 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.