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ClinicalTrials.gov 30 recruiting now official registry

Obsessive - Compulsive Disorder clinical trials

30 of 86 indexed Obsessive - Compulsive Disorder trials are currently recruiting.

86 US clinical trials · 30 currently recruiting

Obsessive - Compulsive Disorder is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Baylor College of Medicine, running 7 of these trials.

The research picture

Obsessive - Compulsive Disorder has 86 registered US clinical trials, 30 of them open to new participants right now, about 35% of the total.

30
recruiting participants now
35%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: Baylor College of Medicine
Phase 16Phase 213Phase 36Phase 44

Active & Recent Trials

86 total, page 1 of 2

RECRUITING 156,000 participants

Retrospective Analyses of TrakStar Database

Neuronetics

NCT06917339

RECRUITING 5,000 participants

Physiological Brain Atlas Development

Vanderbilt University Medical Center

NCT00575081

RECRUITING 1,100 participants

Developing Brain, Impulsivity and Compulsivity

National Institute of Mental Health (NIMH)

NCT04631042

RECRUITING 1,000 participants

University of Iowa Interventional Psychiatry Service Patient Registry

Mark Niciu

NCT04480918

RECRUITING NA 600 participants

CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

University of Texas at Austin

NCT05467683

RECRUITING 500 participants

Discovering Factors in the Clinical Study Journey of Patients With OCD

Power Life Sciences

NCT05881356

RECRUITING NA 400 participants

Mechanisms of Exposure Therapy for OCD

Mclean Hospital

NCT06173752

RECRUITING NA 200 participants

CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD

Baylor College of Medicine

NCT05609916

RECRUITING Phase 2 180 participants

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Brigham and Women's Hospital

NCT06376734

RECRUITING Phase 2 150 participants

Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)

Stanford University

NCT05940324

RECRUITING NA 118 participants

Neural Mechanisms of Response Inhibition Training for OCRD

University of Wisconsin, Milwaukee

NCT05377125

RECRUITING NA 106 participants

Interpretation Bias as a Mechanism of Treatment Response in OCD

Mclean Hospital

NCT05224414

RECRUITING Phase 1 100 participants

Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

Yale University

NCT04131829

RECRUITING 100 participants

A Multicenter Pediatric Deep Brain Stimulation Registry

Boston Children's Hospital

NCT06585618

RECRUITING NA 100 participants

Precision Analytic Research Methods in OCD

Icahn School of Medicine at Mount Sinai

NCT07011901

RECRUITING NA 60 participants

TMS + Exposure Therapy for Pediatric OCD

Bradley Hospital

NCT05931913

RECRUITING Phase 2 60 participants

Study of Dextromethorphan in OCD and Related Disorders

Stanford University

NCT04899687

RECRUITING NA 50 participants

Individually Targeted Neuromodulation for Contamination-based OCD

Mclean Hospital

NCT05048251

RECRUITING NA 48 participants

Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder

Adam Frank

NCT07146438

RECRUITING Phase 2 45 participants

Efficacy of Nitrous Oxide in OCD: Pilot Study

Stanford University

NCT03826693

RECRUITING Phase 1 45 participants

Pilot Study of RR-HNK in OCD

Carolyn Rodriguez

NCT06575075

RECRUITING Phase 2 40 participants

MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)

Carolyn Rodriguez

NCT05783817

RECRUITING NA 30 participants

Using Personalized Assessments in the Treatment of Childhood OCD

Johns Hopkins University

NCT06407648

RECRUITING Phase 1 30 participants

Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

Francisco A Moreno

NCT07347405

RECRUITING Early Phase 1 30 participants

Effects of Psilocybin in Obsessive Compulsive Disorder

Johns Hopkins University

NCT05546658

RECRUITING NA 30 participants

Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

University of California, San Francisco

NCT07065669

RECRUITING NA 16 participants

Caloric Vestibular Stimulation for Modulation of Insight in Obsessive-Compulsive Spectrum Disorders

Stanford University

NCT03918577

RECRUITING NA 15 participants

Cortical Stimulation to Treat Obsessive Compulsive Disorder

Andrew Moses Lee, MD, PhD

NCT04958096

RECRUITING NA 10 participants

Personalized DBS for OCD Guided by Stereoencephalography Mapping

Andrew Moses Lee, MD, PhD

NCT06347978

RECRUITING NA 10 participants

SEEG-Guided DBS for OCD

Casey H. Halpern, M.D.

NCT05623306

ACTIVE NOT RECRUITING NA 250 participants

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

Massachusetts General Hospital

NCT01075672

ACTIVE NOT RECRUITING NA 212 participants

Individualized Neuroimaging Biomarkers for Predicting rTMS Response in OCD

Stanford University

NCT05829681

ACTIVE NOT RECRUITING Phase 2 120 participants

Understanding How Ketamine Brings About Rapid Improvement in OCD

Stanford University

NCT02624596

ACTIVE NOT RECRUITING Phase 2 49 participants

A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder

University of Chicago

NCT05624528

ACTIVE NOT RECRUITING Phase 1 30 participants

Effects of Repeated Psilocybin Dosing in OCD

Yale University

NCT05370911

ACTIVE NOT RECRUITING 27 participants

Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)

Baylor College of Medicine

NCT03459456

ACTIVE NOT RECRUITING Phase 4 27 participants

Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder

Butler Hospital

NCT00640133

ACTIVE NOT RECRUITING NA 20 participants

Imaging-Guided Low Intensity Focused Ultrasound (LIFU)

Baylor College of Medicine

NCT05467085

ACTIVE NOT RECRUITING 8 participants

Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)

Baylor College of Medicine

NCT05915741

ACTIVE NOT RECRUITING NA 5 participants

Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder

Baylor College of Medicine

NCT04806516

ACTIVE NOT RECRUITING NA 3 participants

Development of Adaptive Deep Brain Stimulation for OCD

Baylor College of Medicine

NCT04281134

ACTIVE NOT RECRUITING NA 2 participants

Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)

Baylor College of Medicine

NCT03457675

ACTIVE NOT RECRUITING NA 2 participants

Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder

Massachusetts General Hospital

NCT03184454

COMPLETED 2,069 participants

Clinical Outcomes From NOCD Treatment of Obsessive-Compulsive Disorder Using Exposure and Response Prevention

NOCD

NCT04701372

COMPLETED Phase 3 589 participants

Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder

Biohaven Pharmaceuticals

NCT04693351

COMPLETED NA 559 participants

Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment

Mclean Hospital

NCT02305537

COMPLETED 456 participants

Physiological Brain Atlas Development

Ohio State University

NCT01210534

COMPLETED Phase 4 250 participants

Predicting Treatment Response in Patients With OCD

University of Sao Paulo

NCT03993535

COMPLETED 250 participants

Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder

Vanderbilt University Medical Center

NCT04335175

COMPLETED NA 214 participants

Psychotherapy for Anxiety in Children With Autism Spectrum Disorder

University of South Florida

NCT02028247

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 13
Phase 3 6
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obsessive - Compulsive Disorder Trial Landscape

86 indexed Obsessive - Compulsive Disorder studies · 30 recruiting (35%).

Phase mix: 10 late (III/IV) vs 19 early (I/II).

Top sponsor: Baylor College of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obsessive - Compulsive Disorder?

PlainTrial tracks 86 US clinical trials for Obsessive - Compulsive Disorder, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obsessive - Compulsive Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.