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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,707 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,707 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Enrollment posture brief
Registry condition obesity
OPEN 306 | RECR 29% | LATE 107 | EARLY 196 | RANK #3 | SPON 48
Volume-matched condition peers
Nearest open-share peer: Metastatic Pancreatic Adenocarcinoma (29% recruiting · 38 trials)
Obesity lists 306 open slots (29% of 1,057 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 4 of 22
Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery
University of California, Irvine
NCT05975580
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Heba M. Ismail
NCT05414409
Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients
Northwestern University
NCT06466161
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
The Cleveland Clinic
NCT06802081
Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)
Bettina Mittendorfer
NCT06286761
Trans-nasal Endoscopy for Bariatric Patients
Christopher C. Thompson, MD, MSc
NCT06200961
Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics
Washington University School of Medicine
NCT06397729
Preventing Type 2 Diabetes in Black Emergent Adult
University of North Carolina, Chapel Hill
NCT06848244
Metabolic Pathology of Pediatric NAFLD
University of Oklahoma
NCT05430178
Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
Mayo Clinic
NCT07213466
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
University of Texas Southwestern Medical Center
NCT04838678
Probiotic Intervention Study
University of California, Los Angeles
NCT06030362
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06044935
Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)
True You Weight Loss
NCT06420700
Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
Massachusetts General Hospital
NCT07226947
A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
AbbVie
NCT07291232
A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07437079
Telenutrition for Individuals With SCI
Santa Clara Valley Health & Hospital System
NCT05468437
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
Philip Kern
NCT05051436
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy
Ricard Corcelles
NCT06425016
Time Restricted Feeding, Muscle, and Metabolism
University of Arkansas, Fayetteville
NCT04949451
Social Determinants of Sleep and Obesity
University of Minnesota
NCT05698693
Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
University of Minnesota
NCT06226077
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
University of Washington
NCT06174389
Inspire HER: Inspiring the Heart and Emotions for Radical Health
University of Alabama at Birmingham
NCT06966258
Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women
The Miriam Hospital
NCT05775497
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
University of Colorado, Boulder
NCT06776081
A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy
Eli Lilly and Company
NCT07225556
Brain Outcomes With Lifestyle Change in Down Syndrome
University of Kansas Medical Center
NCT05985486
A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet
Novo Nordisk A/S
NCT07184086
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents
University of Alabama at Birmingham
NCT05268042
Study of BMF-650 in Otherwise Healthy Overweight or Obese Adult Participants
Biomea Fusion
NCT07223216
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
Drexel University
NCT06353464
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
M.D. Anderson Cancer Center
NCT04003038
DNA Methylation and Vascular Function
University of Illinois at Chicago
NCT03527420
Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06223555
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
University of Texas Southwestern Medical Center
NCT05723679
Inspiratory Muscle Training in Obese Breast Cancer Survivors
Ohio State University Comprehensive Cancer Center
NCT05193149
Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
Duke University
NCT05945355
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)
Novo Nordisk A/S
NCT07225816
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
Vanderbilt University Medical Center
NCT05972564
Impact of Yo-Yo Sleep on Cardiometabolic Health
Columbia University
NCT05880758
Small Extracellular Vesicles and Insulin Action
Washington University School of Medicine
NCT05933707
A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
University of Connecticut
NCT07238556
Effects of Obesity in the Aged
University of Texas Southwestern Medical Center
NCT05028309
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
University of Missouri-Columbia
NCT05219799
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
University of Colorado, Denver
NCT06129110
A Study to Improve Skeletal Muscle in Veterans With HIV
VA Office of Research and Development
NCT06845046
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obesity trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obesity page
1,057 registered trials, 306 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 306 Obesity trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eli Lilly and Company sponsors the most Obesity trials on record, review their full trial history before evaluating a specific study. See Eli Lilly and Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obesity condition card totals 1,057 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.