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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,963 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,963 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Open enrollment, early-phase tilt
Obesity has 1,057 registered US clinical trials, 306 of them open to new participants right now, about 29% of the total.
- 306
- recruiting participants now
- 29%
- of trials open to enrollment
- 107
- in Phase 3-4 (later-stage)
- 48
- top sponsor: Eli Lilly and Company
Corpus placement: #3 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 3 of 22
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
National Heart, Lung, and Blood Institute (NHLBI)
NCT01927783
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company
NCT07215559
RemI for Post-Bariatric Surgery Weight Regain
Temple University
NCT06292936
Stand Up for Your Health with a Sit-stand Desk
Medical College of Wisconsin
NCT05585190
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
NCT06173778
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
University of Florida
NCT05561595
Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients
Nitinotes Surgical
NCT07090005
Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial
VA Office of Research and Development
NCT07010757
Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults
University of North Carolina, Chapel Hill
NCT06044571
Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
Salk Institute for Biological Studies
NCT06891352
Stepped Care for Weight Loss Maintenance
Johns Hopkins University
NCT06151145
A Study on How NNC0174-1213 Works in People With Overweight or Obesity.
Novo Nordisk A/S
NCT06719011
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Daily Eating Patterns for Total Health Study
The University of Tennessee, Knoxville
NCT06455995
Motivating Increases in Physical Activity for Prevention of Weight Regain After Metabolic Bariatric Surgery
Hartford Hospital
NCT06484621
Pharmacological and Behavioral Treatment After Bariatric Surgery
Yale University
NCT05157698
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
Cedars-Sinai Medical Center
NCT05653258
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
University of Alabama at Birmingham
NCT04971720
Sit Less, Interact and Move More (SLIMM) 2 Study
Srinvasan Beddhu
NCT05173714
Investigating the Impact of Obesity on Pubertal Development in Girls
National Institute of Environmental Health Sciences (NIEHS)
NCT02583646
Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity
The Methodist Hospital Research Institute
NCT06339320
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Brigham and Women's Hospital
NCT06105164
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
Brigham and Women's Hospital
NCT05728697
MEHMO Natural History and Biomarkers
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT06019182
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
VA Office of Research and Development
NCT05880108
Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06169137
Program for Fully Understanding Eating and Lifestyle Change (FUEL)
The Miriam Hospital
NCT05562427
RESCUE: Discontinuation of GLP-1
Boston Scientific Corporation
NCT07190794
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00739362
A Culturally-relevant Micronutrient-dense Plant-rich (mNDPR) Dietary Intervention for Native Americans
Northern Arizona University
NCT04755062
A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
Children's Hospital Medical Center, Cincinnati
NCT06028113
Project VIBE: Virtual Intervention for Binge Eating in Adolescents
University of Pittsburgh
NCT06819813
First in Human Study in Subjects With Obesity, But Otherwise Healthy
NeuroBo Pharmaceuticals
NCT06252220
A Study of a Novel Precision Medicine Approach For Obesity
Mayo Clinic
NCT06814938
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
EMPOWER: Effects of Weight Loss and Exercise Post-stroke
Medical University of South Carolina
NCT05901675
Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity
University of Connecticut
NCT05700916
Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
University of Mississippi Medical Center
NCT05530434
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
University of Colorado, Denver
NCT06582875
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Eli Lilly and Company
NCT06672549
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Eli Lilly and Company
NCT06672939
tDCS With Cognitive Training to Reduce Impulsivity and Weight in Veterans With Obesity
VA Office of Research and Development
NCT05225233
Bone Metabolism in 12-21 Year Olds Undergoing GLP-1 Receptor Agonist Therapy
University of Virginia
NCT06903923
Exercise Training and Fat Metabolism in Postmenopausal Women
Florida State University
NCT05351476
Dietary Intervention to Improve Kidney Transplant Outcomes
University of California, Davis
NCT05449496
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion
Columbia University
NCT05919797
Fibrosis Lessens After Metabolic Surgery
Ali Aminian
NCT06374875
A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity
Eli Lilly and Company
NCT07232732
Thermogenic Silencer Regulatory Factors in Humans
Rockefeller University
NCT06424132
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05545306
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Obesity right now
306 recruiting of 1,057 indexed (29% open).
Phase mix: 107 late (III/IV) vs 196 early (I/II) (early-phase heavy).
Top sponsor: Eli Lilly and Company (48 trials), 9 others listed. 50 shown below, recruiting first. #3 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Obesity?
PlainTrial tracks 1,057 US clinical trials for Obesity, of which 306 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Obesity?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.