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NCT06802081 · ClinicalTrials.gov registry record · Phase 2

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

A Phase 2 study of Obesity and Atrial Fibrillation, sponsored by The Cleveland Clinic.

Recruiting
Registry status
Phase 2
Development phase
100
Enrollment target
1
Study location

NCT06802081 is a Phase 2 study of Obesity and Atrial Fibrillation that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 100 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06802081, a Phase 2 study of Obesity and Atrial Fibrillation, is actively recruiting participants, sponsored by The Cleveland Clinic.

RECRUITING
Registry status
Phase 2
Development phase
100 participants
Enrollment target
1
Study location

Study Summary

This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom severity, and burden of AFIB at 12 months.

Conditions Studied

Obesity Atrial Fibrillation

Interventions

  • DRUG Placebo
  • DRUG Tirzepatide

Study Locations (1)

Ohio

  • Cleveland Clinic - Cleveland

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2025-04-08
Est. Completion 2027-06-01
Phase Phase 2

Sponsor

The Cleveland Clinic

688 total trials

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What the Registry Record Tells You About NCT06802081

The ClinicalTrials.gov registry entry for NCT06802081 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (88% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06802081 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT06802081 about?

NCT06802081 is a clinical study titled "TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation". This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom sever...

What is the current status of trial NCT06802081?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2025-04-08. Estimated completion is 2027-06-01.

What conditions does trial NCT06802081 study?

This clinical trial studies the following conditions: Obesity, Atrial Fibrillation.

What interventions are being tested in trial NCT06802081?

The interventions under investigation include: Placebo (DRUG), Tirzepatide (DRUG).

Who is sponsoring clinical trial NCT06802081?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06802081 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.