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Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 1 of 14
Retrospective Analyses of TrakStar Database
Neuronetics
NCT06917339
Social Needs Screening and Chronic Diseases Study (WE CARE)
University of Massachusetts, Worcester
NCT06903897
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
Neuronetics
NCT06997549
Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
Duke University
NCT06595251
Characterization and Treatment of Adolescent Depression
National Institute of Mental Health (NIMH)
NCT03388606
Reaching Out to Distressed Medical Residents, Fellows and Faculty
Oregon Health and Science University
NCT02010866
Evaluation of the PACE/PACENET BHL Clinical Program
University of Pennsylvania
NCT02463266
Cognitive and Affective Processes Online
University of Minnesota
NCT05736471
Dallas 2K: A Natural History Study of Depression
University of Texas Southwestern Medical Center
NCT02919280
Resilience in Adolescent Development
University of Texas Southwestern Medical Center
NCT03458936
Digital CBT for Insomnia and Depression
University of Rochester
NCT05456607
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
Massachusetts General Hospital
NCT06557005
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
George Washington University
NCT04913766
Long-term Observation of Participants With Mood Disorders
National Institute of Mental Health (NIMH)
NCT04877977
S.T.A.N.D. Alacrity Center Signature Project
University of California, Los Angeles
NCT05591937
Kintsugi Voice Device Pivotal Study
Kintsugi Mindful Wellness
NCT06809907
ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start
Oregon Research Institute
NCT05142384
RCT for Latina Mental Health Using Web-Based Apps
University of California, Los Angeles
NCT06874790
Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
Johns Hopkins University
NCT07227337
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
University of Arkansas
NCT06923423
Confirmatory Efficacy Trial of Attention Bias Modification for Depression
University of Texas at Austin
NCT06361095
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
Cefaly Technology
NCT06788977
Antidepressant Adherence for Depressed Adults in Primary Care
University of Pennsylvania
NCT06496646
Sleep to Reduce Incident Depression Effectively in Peripartum
Henry Ford Health System
NCT06430333
Brain Stimulation and Decision-making
Emory University
NCT04099056
Filipino Family Health Initiative 1.0
Kaiser Permanente
NCT06569303
Internet Based Psychological Support
Dartmouth-Hitchcock Medical Center
NCT02726061
Accelerated TMS for Depression and OCD
Weill Medical College of Cornell University
NCT04982757
The Nuestros Días ("Our Days") Study
University of Alabama at Birmingham
NCT06475534
Computerized Cognitive Behavioral Therapies for Suicide Prevention and Depression
VA Eastern Colorado Health Care System
NCT06375083
Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older
University of Illinois at Chicago
NCT06636058
Assessing Improvements in Mood and Sleep Trial
University of Pittsburgh
NCT06639477
Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
University of Washington
NCT06494384
E-Mindfulness Approaches for Living After Breast Cancer
NRG Oncology
NCT06748222
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Duke University
NCT06538246
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
Yale University
NCT06713616
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families
Duke University
NCT06627764
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
University of Tennessee
NCT06374277
Cannabidiol and Older Adult Cannabis Users
University of Colorado, Boulder
NCT06290063
Cocooned Moms Study
InovCares Connected Comprehensive Healthcare Corporation
NCT06968650
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
AbbVie
NCT04777357
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Johns Hopkins University
NCT05663034
Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
Penn State University
NCT05789446
Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
Medical University of South Carolina
NCT05497115
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
NCT06793397
Neurobiology of Suicide
National Institute of Mental Health (NIMH)
NCT02543983
Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)
University of North Carolina, Chapel Hill
NCT06587230
Families With Pride ("Familias Con Orgullo").
University of Miami
NCT06057337
Equipping Patients Using Interventions for Pain and Depression
Indiana University
NCT06500780
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.