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NCT05430178 · ClinicalTrials.gov registry record · NA
Metabolic Pathology of Pediatric NAFLD
A NA study of Obesity and Nonalcoholic Steatohepatitis, sponsored by University of Oklahoma.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT05430178 is a NA study of Obesity and Nonalcoholic Steatohepatitis that is actively recruiting participants, run by University of Oklahoma. The registered enrollment target is 100 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05430178, a NA study of Obesity and Nonalcoholic Steatohepatitis, is actively recruiting participants, sponsored by University of Oklahoma.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Nonalcoholic fatty liver disease (NAFLD) is now the most common liver disease worldwide and affects nearly 40% of obese youth and up to 10% of the general pediatric population. Some features of NAFLD are similar in children and adults, yet fibrosis and inflammation are more common in the portal zone and occur earlier in pediatric NAFLD patients than adults. This portends a rapid progression to end-stage liver disease in early adulthood. For the majority of children with NAFLD, mechanisms driving the origin and rapid progression of disease remain unknown. Thus, there is a critical, unmet need to study the specific underlying patterns of metabolic and molecular changes in the liver underlying the development and progression unique to children with NAFLD. This proposal will test the hypotheses that children with NAFLD have excess glucose and lipid produced by the liver, that those events are regulated by specific variations in the amount and location of RNAs and proteins in liver, and that the concentration of specific micro-RNAs in the blood can be used as a biomarker for NAFLD in pediatric patients.
Conditions Studied
Interventions
- OTHER Oral sugar tolerance test
- OTHER De novo lipogenesis test
- OTHER Gluconeogenesis test
Study Locations (1)
Oklahoma
- University of Oklahoma Health Sciences Center - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2022-05-25 |
| Est. Completion | 2026-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05430178
The ClinicalTrials.gov registry entry for NCT05430178 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (88% lower). The listed sponsor is University of Oklahoma, which has 358 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Obesity appearing as the primary indexed condition, and to 3 interventions - of which Oral sugar tolerance test is the first listed.
NCT05430178 reports 1 study location spanning 1 distinct geographic area - top geographies include Oklahoma.
Frequently Asked Questions
What is clinical trial NCT05430178 about?
NCT05430178 is a clinical study titled "Metabolic Pathology of Pediatric NAFLD". Nonalcoholic fatty liver disease (NAFLD) is now the most common liver disease worldwide and affects nearly 40% of obese youth and up to 10% of the general pediatric population. Some features of NAFLD are similar in children and adults, yet fibrosis and inflammation are more common in the portal zone...
What is the current status of trial NCT05430178?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2022-05-25. Estimated completion is 2026-06.
What conditions does trial NCT05430178 study?
This clinical trial studies the following conditions: Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver.
What interventions are being tested in trial NCT05430178?
The interventions under investigation include: Oral sugar tolerance test (OTHER), De novo lipogenesis test (OTHER), Gluconeogenesis test (OTHER).
Who is sponsoring clinical trial NCT05430178?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05430178 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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