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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,707 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,707 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Enrollment posture brief
Registry condition obesity
OPEN 306 | RECR 29% | LATE 107 | EARLY 196 | RANK #3 | SPON 48
Volume-matched condition peers
Nearest open-share peer: Metastatic Pancreatic Adenocarcinoma (29% recruiting · 38 trials)
Obesity lists 306 open slots (29% of 1,057 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 5 of 22
Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
AdventHealth Translational Research Institute
NCT06602141
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
USDA, Western Human Nutrition Research Center
NCT04293224
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure
University of North Carolina, Chapel Hill
NCT07216820
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
Stanford University
NCT05912621
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
NCT07142707
Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
NCT03866408
Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
Massachusetts General Hospital
NCT05933499
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
Bettina Mittendorfer
NCT06335771
A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults
Shanghai World Leader Pharmaceutical Co.
NCT07465965
Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics
Washington University School of Medicine
NCT06063564
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Bettina Mittendorfer
NCT06571474
Low Oxygen Exposure and Weight Status
Pennington Biomedical Research Center
NCT05289310
Role of Adiposomes in Endothelial Dysfunction
University of Illinois at Chicago
NCT05199454
Treating Binge Eating and Obesity Digitally in Black Women
University of North Carolina, Chapel Hill
NCT05693896
The Mind-Body Project
Northeastern University
NCT07139795
A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity
Boehringer Ingelheim
NCT06745284
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
University of Colorado, Denver
NCT03885245
Mitigating the Pro-inflammatory Phenotype of Obesity
University of Kansas Medical Center
NCT04934228
Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension
University of Kansas Medical Center
NCT06626113
Extracellular Vesicles, Insulin Action, and Exercise
Rutgers, The State University of New Jersey
NCT06546085
HIIT Effects on Cardiometabolic Health
Syracuse University
NCT05838950
With Love, Grandma ("Con Cariño, Abuelita") Pilot Study
University of Miami Sylvester Comprehensive Cancer Center
NCT05721976
Comparison of Body Composition Changes With Weight Loss Interventions
Vanderbilt University Medical Center
NCT07115069
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
Anti Inflammatory Lipid Mediators in Asthma Lipid Anti-Inflammtory Mediators in Asthma
University of Colorado, Denver
NCT03762395
The Weight of Cardiovascular Disease
Mayo Clinic
NCT06053645
Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic/Latino/a/x Adults
New York University
NCT06795386
Thermogenenic Responses to Fasting and Overfeeding in Women
University of Colorado, Denver
NCT06610162
A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.
Pfizer
NCT07400679
Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment
Yale University
NCT06411210
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Milton S. Hershey Medical Center
NCT06482853
Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity
VA Office of Research and Development
NCT06745063
Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors
Roswell Park Cancer Institute
NCT03880422
Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
Oregon Research Institute
NCT05437809
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
University of Colorado, Denver
NCT03215836
Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT07400588
Regional Lipolysis Insulin Regulation
Mayo Clinic
NCT06392854
Full Plate Living Nutrition Education Program
University of Wisconsin, Madison
NCT07271940
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
San Diego State University
NCT05279729
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
University of New Hampshire
NCT05912348
Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)
University of California, Irvine
NCT06783751
Inspiratory Muscle Strength Training in Adults With Obesity
Florida State University
NCT05459636
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06325722
Circadian Misalignment and Energy Balance
Columbia University
NCT03663530
Fasted vs. Fed State Exercise
Arkansas Colleges of Health Education
NCT07487090
A Single Ascending Dose Study of HM17321 in Healthy Adult Participants
Hanmi Pharmaceutical Company Limited
NCT07219589
How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types
George Washington University
NCT06691100
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
Washington University School of Medicine
NCT07097506
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obesity trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obesity page
1,057 registered trials, 306 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 306 Obesity trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eli Lilly and Company sponsors the most Obesity trials on record, review their full trial history before evaluating a specific study. See Eli Lilly and Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obesity condition card totals 1,057 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.